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Aviptadil
Klinik ma'lumotlar
AHFS/Drugs.com	Giyohvand moddalarning xalqaro nomlari
ATC kodi	yo'q;
Identifikatorlar
CAS raqami	40077-57-4 ;
PubChem CID	16132300;
ChemSpider	17288959 ;
UNII	A67JUW790C;
ChEMBL	ChEMBL2106041 ;
CompTox boshqaruv paneli (EPA)	DTXSID7048584 ;
Kimyoviy va fizik ma'lumotlar
Formula	C147H237N43O43S
Molyar massa	3326.83 g · mol−1
3D model (JSmol)	Interaktiv rasm;
	Jilmayganlar CCC (C) C (C (= O) bosimining ko'tarilishi (CC (C) C) C (= O) bosimining ko'tarilishi (CC (= O) N) C (= O) O) bosimining ko'tarilishi (= O) C (CO) bosimining ko'tarilishi (= O) C (CC (= O) N) NC (= O) C (CC (C) C) NC (= O) C (Cc1ccc (cc1) O) NC (= O) C (CCCCN) NC () = O) C (CCCCN) bosimining ko'tarilishi (= O) C (C (C) C) bosimining ko'tarilishi (= O) C (C) bosimining ko'tarilishi (= O) C (CCSC) bosimining ko'tarilishi (= O) C (CCC (= O) N) bosimining ko'tarilishi (= O) C (CCCCN) bosimining ko'tarilishi (= O) C (CCCNC (= N) N) bosimining ko'tarilishi (= O) C (CC (C) C) bosimining ko'tarilishi (= O) C (CCCNC (= N) N) bosimining ko'tarilishi (= O) C (C (C) O) bosimining ko'tarilishi (= O) C (Cc2ccc (cc2) O) bosimining ko'tarilishi (= O) C (CC (= O) N) bosimining ko'tarilishi (= O) C (CC) (= O) O) bosimining ko'tarilishi (= O) C (C (C) O) bosimining ko'tarilishi (= O) C (Cc3ccccc3) bosimining ko'tarilishi (= O) C (C (C) C) bosimining ko'tarilishi (= O) C (C) NC (= O) C (CC (= O) O) NC (= O) C (CO) NC (= O) C (Cc4cnc [nH] 4) N;
	InChI InChI = 1S / C147H237N43O43S / c1-18-75 (12) 115 (142 (229) 180-96 (56-72 (6) 7) 131 (218) 183-104 (145 (232) 233) 63-110) 155) 200) 188-139 (226) 106 (68-192) 185-134 (221) 101 (62-109 (154) 199) 177-130 (217) 95 (55-71 (4) 5) 174-) 132 (219) 97 (58-81-37-41-84 (195) 42-38-81) 175-125 (212) 88 (33-23-26-49-149) 167-123 (210) 89 () 34-24-27-50-150) 171-140 (227) 113 (73 (8) 9) 186-118 (205) 76 (13) 164-121 (208) 93 (47-53-234-17) 170-127 (214) 92 (45-46-107 (152) 197) 169-122 (209) 87 (32-22-25-48-148) 166-124 (211) 90 (35-28-51-) 161-146 (156) 157) 168-129 (216) 94 (54-70 (2) 3) 173-126 (213) 91 (36-29-52-162-147 (158) 159) 172-143) 230) 116 (78 (15) 193) 189-136 (223) 98 (59-82-39-43-85 (196) 44-40-82) 176-133 (220) 100 (61-108 (153)) 198) 178-135 (222) 103 (65-112 (203) 204) 182-144 (231) 117 (79 (16) 194) 190-137 (224) 99 (57-80-30-20-19-) 21-31-80) 181-141 (228) 114 (74 (10) 11) 187-119 (206) 77 (14) 165-128 (215) 102 (64-111 (201) 202) 179-138 () 225) 105 (67-191) 184-120 (207) 86 (151) 60-83-66-160-69-163-83 / h19-21,30-31,37-44,66,69-79, 86-106,113-117,191-196H, 18,22-29,32-36,45-65,67-68,148-151H2,1-17H3, (H2,152,197) (H2,153,198) (H2,154,199) (H 2,155,200) (H, 160,163) (H, 164,208) (H, 165,215) (H, 166,211) (H, 167,210) (H, 168,216) (H, 169,209) (H, 170,214) (H, 171,227) (H, 172,230) (H, 173,213) (H, 174,219) (H, 175,212) (H, 176,220) (H, 177,217) (H, 178,222) (H, 179,225) (H, 180,229) (H, 181,228) (H, 182,231) (H, 183,218) (H, 184,207) (H, 185,221) (H, 186,205) (H, 187,206) (H, 188,226) (H, 189,223) (H, 190,224) (H, 201,202) (H, 203,204) (H, 232,233) (H4,156,157,161) (H4,158,159,162) / t75-, 76-, 77-, 78 +, 79 +, 86-, 87-, 88-, 89-, 90-, 91- , 92-, 93-, 94-, 95-, 96-, 97-, 98-, 99-, 100-, 101-, 102-, 103-, 104-, 105-, 106-, 113-, 114 -, 115-, 116-, 117- / m0 / s1 ; Kalit: VBUWHHLIZKOSMS-RIWXPGAOSA-N ;
	(bu nima?) (tasdiqlash)

Aviptadil

Aviptadil (KARVONSAROY) ning analogidir vazoaktiv ichak polipeptidi Davolash uchun (VIP) erektil disfunktsiya.^[1] Jenevada joylashgan Relief Therapeutics Holdings AG RFLB.S o'pkani himoya qiluvchi tabiiy peptidning sintetik shakli bo'lgan RLF-100 patentiga ega. AQSh-Isroilning NeuroRx Inc kompaniyasi AQShda ushbu preparatni ishlab chiqarishda Relief bilan hamkorlik qildi. 2020 yil iyun oyida AQSh Oziq-ovqat va dori-darmonlarni boshqarish Nafas olish qiyinlishuvini davolash uchun RLF-100 ga tezkor nom berildi COVID-19.^[2] 2020 yil sentyabr oyida NeuroRX intensiv terapiyadagi bemorlarda foydalanish uchun AQSh FDAga Favqulodda vaziyatlarda avtorizatsiya qilish to'g'risida so'rov yubordi. ^[3]

Adabiyotlar

^ Keijzers GB (aprel, 2001 yil). "Aviptadil (Senatek)". Tergov dori-darmonlari bo'yicha hozirgi fikr. 2 (4): 545–9. PMID 11566015.
^ "Og'ir kasal bo'lgan KOVID-19 kasallari RLF-100 davolash yordamida tez tiklanishadi". Nyu-York Post. 2 avgust 2020. Olingan 3 avgust 2020.
^ NeuroRx. "NeuroRx Kritik COVID-19 va nafas olish etishmovchiligi bo'lgan, tasdiqlangan terapiyani tugatgan bemorlarni davolashda RLF-100 ™ (aviptadil) uchun favqulodda vaziyatlarda avtorizatsiya qilish uchun so'rov yuboradi". www.prnewswire.com. Olingan 2020-09-24.

[pmid11566015-1] Keijzers GB (aprel, 2001 yil). "Aviptadil (Senatek)". Tergov dori-darmonlari bo'yicha hozirgi fikr. 2 (4): 545–9. PMID 11566015.

[2] "Og'ir kasal bo'lgan KOVID-19 kasallari RLF-100 davolash yordamida tez tiklanishadi". Nyu-York Post. 2 avgust 2020. Olingan 3 avgust 2020.

[3] NeuroRx. "NeuroRx Kritik COVID-19 va nafas olish etishmovchiligi bo'lgan, tasdiqlangan terapiyani tugatgan bemorlarni davolashda RLF-100 ™ (aviptadil) uchun favqulodda vaziyatlarda avtorizatsiya qilish uchun so'rov yuboradi". www.prnewswire.com. Olingan 2020-09-24.

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