WikiDer > Etinamat

Etinamat
Klinik ma'lumotlar
AHFS/Drugs.com	Micromedex iste'molchilar haqida batafsil ma'lumot
Marshrutlari; ma'muriyat	Og'zaki
ATC kodi	yo'q;
Huquqiy holat
Huquqiy holat	CA: IV jadval ; DE: Anlage II (Faqat vakolatli savdo, retsept bo'yicha emas) ; Umuman olganda: ℞ (faqat retsept bo'yicha);
Identifikatorlar
	IUPAC nomi (1-etinilsikloheksil) karbamat;
CAS raqami	126-52-3 ;
PubChem CID	3284;
IUPHAR / BPS	7325;
DrugBank	DB01031 ;
ChemSpider	3169 ;
UNII	IAN371PP48;
KEGG	D00703 ;
ChEBI	CHEBI: 4884 ;
ChEMBL	ChEMBL1576 ;
CompTox boshqaruv paneli (EPA)	DTXSID7023013 ;
ECHA ma'lumot kartasi	100.004.355
Kimyoviy va fizik ma'lumotlar
Formula	C9H13NO2
Molyar massa	167.208 g · mol−1
3D model (JSmol)	Interaktiv rasm;
	Jilmayganlar O = C (OC1 (C # C) CCCCC1) N;
	InChI InChI = 1S / C9H13NO2 / c1-2-9 (12-8 (10) 11) 6-4-3-5-7-9 / h1H, 3-7H2, (H2,10,11) ; Kalit: GXRZIMHKGDIBEW-UHFFFAOYSA-N ;
	(tasdiqlash)

Ethinamate

Etinamat (Valamin, Valmid) qisqa muddatli karbamat- hosila sedativ-gipnoz dorilar davolash uchun ishlatiladi uyqusizlik. Muntazam foydalanish olib keladi giyohvandlikka chidamlilik, va odatda 7 kundan ortiq vaqt davomida samarali bo'lmaydi. Uzoq muddatli foydalanish olib kelishi mumkin qaramlik.^{[iqtibos kerak]}

Etinamat boshqa dorilar bilan almashtirildi (xususan benzodiazepinlar), va u mavjud emas Gollandiya, Qo'shma Shtatlar yoki Kanada.^{[iqtibos kerak]}

Sintez

Etinamat (1-etinilsikloheksonon karbamat) kombinatsiyalash orqali sintezlanadi asetilen bilan sikloheksanon qilish 1-etinitsikloheksanolva keyin uni a ga o'zgartiring karbamat bilan keyingi reaktsiya bilan fosgenva keyinchalik ammiak. Atsetilen birinchi bosqichda sikloheksanon bilan reaksiyaga kirishishi uchun ba'zi bir lityum metall yoki shunga o'xshashlar ishlatiladi.^[1]^[2]

Adabiyotlar

^ X. Pfayfer, K. Yunkman, AQSh Patenti 2,816,910 (1957)
^ H. Emde, V. Grimme, DE 1021843 (1953)

Bu tinchlantiruvchibilan bog'liq maqola a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.

[1] X. Pfayfer, K. Yunkman, AQSh Patenti 2,816,910 (1957)

[2] H. Emde, V. Grimme, DE 1021843 (1953)

[1]

[2]

v t e GABA_A retseptorlari ijobiy modulyatorlari
Spirtli ichimliklar	Brometon Butanol Xloralodol Xlorobutanol (kloreton) Etanol (alkogol) (alkogolli ichimlik) Etxlorvinol Izobutanol Izopropanol Mentol Metanol Metilpentinol Pentanol Petrikloral Propanol tert-Butanol (2M2P) tert-Pentanol (2M2B) Tribromoetanol Trikloroetanol Triklofos Trifloroetanol
Barbituratlar	(-) - DMBB Allobarbital Alfenal Amobarbital Aprobarbital Barbeksaklon Barbital Benzobarbital Benzilbutilbarbiturat Brallobarbital Brophebarbital Butabarbital / Secbutabarbital Butalbital Buthalital Butobarbital Butallylonal Uglerod Krotilbarbital Siklobarbital Siklopentobarbital Difebarbamat Enalilpropimal Etallobarbital Eterobarb Febarbamat Heptabarb Geptobarbital Geksetal Geksobarbital Metarbital Metitural Metekeksital Metilfenobarbital Narkobarbital Nealbarbital Pentobarbital Fenalmal Fenobarbital Fetarbital Primidon Probarbital Propallylonal Propilbarbital Proksibarbital Qaytarish Sekobarbital Sigmodal Spirobarbital Talbutal Tetrabamat Tetrabarbital Thialbarbital Tiamilal Tiobarbital Thiobutabarbital Thiopental Thiotetrabarbital Valofan Vinbarbital Vinilbital
Benzodiazepinlar	2-oksokazepam 3-gidroksifenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Brotizolam Kamazepam Karburazepam Xlordiazepoksid Tsiklotizolam Cinazepam Cinolazepam Klazolam Klimazolam Clobazam Klonazepam Klonazolam Kloniprazepam Klorazepat Clotiazepam Kloksazolam CP-1414S Kiprazepam Delorazepam Demoksepam Diazepam Diklazepam Doksefazepam Elfazepam Estazolam Etil karfluzepat Etil dirazepat Etil loflazepat Etizolam EVT-201 FG-8205 Fletazepam Flubromazepam Flubromazolam Fludiazepam Flunitrazepam Flunitrazolam Flurazepam Flutazolam Flutemazepam Flutoprazepam Fosazepam Gidazepam Halazepam Haloksazolam Iclazepam Imidazenil Irazepin Ketazolam Lofendazam Lopirazepam Loprazolam Lorazepam Lormetazepam Meklonazepam Medazepam Menitrazepam Metaklazepam Mexazolam Midazolam Motrazepam N-Desalkilflurazepam Nifoksipam Nimetazepam Nitrazepam Nitrazepat Nitrazolam Nordazepam Nortetrazepam Oksazepam Oksazolam Fenazepam Pinazepam Pivoksazepam Prazepam Premazepam Proflazepam Pirazolam QH-II-66 Kvazepam Reclazepam Remimazolam Rilmazafone Ripazepam Ro48-6791 Ro48-8684 SH-053-R-CH3-2′F Sulazepam Temazepam Tetrazepam Tolufazepam Triazolam Triflubazam Triflunordazepam (Ro5-2904) Tuclazepam Uldazepam Zapizolam Zolazepam Zomebazam
Karbamatlar	Karisbamat Karizoprodol Klocental Siklarbamat Difebarbamat Emilkamat Etinamat Febarbamat Felbamat Geksapropimat Lorbamat Mebutamat Meprobamat Nisobamat Pentabamat Fenprobamat Prokurat Stiramat Tetrabamat Tybamate
Flavonoidlar	6-metilapigenin Ampelopsin (dihidromiritsetin) Apigenin Baicalein Baikalin Katexin EGC EGCG Hispidulin Linarin Luteolin Rc-OMe Bosh suyagi tarkibiy qismlar (masalan, baikalin) Vogonin
Imidazollar	Etomidate Metomidat Propoksat
Kava tarkibiy qismlar	10-metoksiyangonin 11-metoksiyangonin 11-gidroksiyangonin Desmetoksiyangonin 11-metoksi-12-gidroksidigidrokavain 7,8-Dihidroyangonin Kavain 5-gidroksikavain 5,6-Dihidroyangonin 7,8-Dihidrokavain 5,6,7,8-Tetrahidroyangonin 5,6-dehidrometististin Metistitsin 7,8-Dihidrometistitsin Yangonin
Monoureidlar	Acecarbromal Apronal (apronalid) Bromisoval Karbromal Kapurid Ektilüre
Neyroaktiv steroidlar	Acebrochol Allopregnanolon (brexanolon) Alfadolon Alfaxalone 3a-Androstandiol Androstenol Androsteron Aniq anabolik-androgenik steroidlar Xolesterin DHDOC 3a-DHP 5a-DHP 5β-DHP DHT Etioxolanolon Ganaxolone Gidroksidion Minaxolon ORG-20599 ORG-21465 P1-185 Pregnanolon (eltanolon) Progesteron Renanolon SAGE-105 SAGE-324 SAGE-516 SAGE-689 SAGE-872 Testosteron THDOC Zuranolone
Nonbenzodiazepinlar	Siklopirrolonlar: Eszopiklon Pagoklon Pazinaklon Suproklon Suriklon Zopiklon Imidazopiridinlar: Alpidem DS-1 Nekopidem Saripidem Zolpidem Pirazolopirimidinlar: Divaplon Fasiplon Indiplon Lidorli diplom Ocinaplon Panadiplon Taniplon Zaleplon Boshqalar: Adipiplon CGS-8216 CGS-9896 CGS-13767 CGS-20625 CL-218,872 CP-615,003 CTP-354 ELB-139 GBLD-345 Imepitoin JM-1232 L-838,417 Lirequinil (Ro41-3696) NS-2664 NS-2710 NS-11394 Pipequaline ROD-188 RWJ-51204 SB-205,384 SX-3228 TGSC01AA TP-003 TPA-023 TP-13 U-89843A U-90042 Viqualin Y-23684
Fenollar	Fospropofol Propofol Timol
Piperidinediones	Glutetimid Metiprilon Piperidion Piritildion
Pirazolopiridinlar	Kartazolat Etazolat ICI-190,622 Trakazolat
Kinazolinonlar	Aflokalon Klorokalon Diproqualone Etaqualon Mebroqualone Meklokalon Metakualone Metilmetakualon Nitrometakualon SL-164
Uchuvchi/gazlar	Aseton Asetofenon Asetilglisinamid xloralgidrat Alifluran Benzol Butan Butilen Centalun Xloral Xloral betain Xlorli gidrat Xloroform Kriyofloran Desfluran Dikloralfenazon Diklorometan Dietil efir Enfluran Etil xlorid Etilen Fluroksen Benzin Halopropan Halotan Isofluran Kerosin Metoksifluran Metoksipropan Azot oksidi Azot Azot oksidi Norfluran Paraldegid Propan Propilen Rofluran Sevofluran Sintan Tefluran Toluen Trikloretan (metil xloroform) Trikloretilen Vinil efir
Boshqalar / saralanmagan	3-gidroksibutanal a-EMTBL AA-29504 Avermektinlar (masalan, ivermektin) Bromid birikmalar (masalan, lityum bromid, kaliy bromidi, natriy bromidi) Karbamazepin Xloraloza Xlormezanon Klometiyazol DEABL Dihidroergolinlar (masalan, dihidroergokriptin, dihidroergozin, dihidroergotamin, ergoloid (dihidroergotoksin)) DS2 Efavirenz Etazepin Etifoksin Fenamatlar (masalan, flufenamik kislota, mefenamik kislota, niflumik kislota, tolfenamik kislota) Fluoksetin Flupirtin Hopantenik kislota Lantan Lavanda yog'i Lignanlar (masalan, 4-O-metilxonokiol, honokiol, magnolol, obovatol) Loreclezole Mentil izovalerat (validolum) Monastrol Niasin Nikotinamid (niatsinamid) Org 25,435 Fenitoin Propanidid Retigabin (ezogabine) Safranal Seproksetin Stiripentol Sulfonilalkanlar (masalan, sulfanmetan (sulfanal), tetronal, trional) Terpenoidlar (masalan, borneol) Topiramat Valeriya tarkibiy qismlar (masalan, izovaler kislotasi, izovaleramid, valeren kislotasi, valerenol) Saralangan benzodiazepin saytining ijobiy modulyatorlari: a-Pinene MRK-409 (MK-0343) TCS-1105 TCS-1205
Shuningdek qarang: Retseptor / signalizatsiya modulyatorlari • GABA retseptorlari modulyatorlari • GABA metabolizmi / transport modulyatorlari

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Sintez

Adabiyotlar

Klinik ma'lumotlar

AHFS/Drugs.com	Micromedex iste'molchilar haqida batafsil ma'lumot
Marshrutlari ma'muriyat	Og'zaki
ATC kodi	yo'q
Huquqiy holat
Huquqiy holat	CA: IV jadval DE: Anlage II (Faqat vakolatli savdo, retsept bo'yicha emas) Umuman olganda: ℞ (faqat retsept bo'yicha)
Identifikatorlar
IUPAC nomi (1-etinilsikloheksil) karbamat
CAS raqami	126-52-3^Y
PubChem CID	3284
IUPHAR / BPS	7325
DrugBank	DB01031^Y
ChemSpider	3169^Y
UNII	IAN371PP48
KEGG	D00703^Y
ChEBI	CHEBI: 4884^Y
ChEMBL	ChEMBL1576^Y
CompTox boshqaruv paneli (EPA)	DTXSID7023013
ECHA ma'lumot kartasi	100.004.355
Kimyoviy va fizik ma'lumotlar
Formula	C₉H₁₃NO₂
Molyar massa	167.208 g · mol⁻¹
3D model (JSmol)	Interaktiv rasm
Jilmayganlar O = C (OC1 (C # C) CCCCC1) N
InChI InChI = 1S / C9H13NO2 / c1-2-9 (12-8 (10) 11) 6-4-3-5-7-9 / h1H, 3-7H2, (H2,10,11)^Y Kalit: GXRZIMHKGDIBEW-UHFFFAOYSA-N^Y
(tasdiqlash)