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I-SMAD

I-SMAD yoki ingibitor SMAD ning subklassidir SMADlar modulyatsiyasida ishtirok etadigan o'sish omilining beta-versiyasini o'zgartirish ligandlar. Ushbu sinf o'z ichiga oladi SMAD6 va SMAD7. Ular raqobatlashadi SMAD4 va natijada uning gen mahsulotlarining transkripsiyasini tartibga soladi.

Shuningdek qarang

Tashqi havolalar

I-Smad + oqsillari AQSh Milliy tibbiyot kutubxonasida Tibbiy mavzu sarlavhalari (MeSH)

Uyali signalizatsiya: TGFβ signalizatsiya yo'li

TGF beta ligandlarning superfamilasi

Ligand of ACVR yoki TGFBR	TGF beta-oilasi TGF-β1 TGF-β2 TGF-β3 Aktivin va inhibin INHA INHBA INHBB INHBC Nodal
Ligand of BMPR	Suyak morfogenetik oqsillari BMP2 BMP3 BMP4 BMP5 BMP6 BMP7 BMP8a BMP8b BMP10 BMP15 O'sishni farqlash omillari GDF1 GDF2 GDF3 GDF5 GDF6 GDF7 Myostatin / GDF8 GDF9 GDF10 GDF11 GDF15 Mullerga qarshi gormon

TGF beta retseptorlari
(Aktivin, BMP, oila)

TGFBR1:	Activin 1-turdagi retseptorlari ACVR1 ACVR1B ACVR1C ACVRL1 BMPR1 BMPR1A BMPR1B
TGFBR2:	Activin tipidagi 2-retseptorlari ACVR2A ACVR2B AMHR2 BMPR2
TGFBR3:	betaglikan

Transduserlar/SMAD

Ligand inhibitörleri

Boshqalar

SARA

Transkripsiya omillari va hujayra ichidagi retseptorlari

(1) Asosiy domenlar

(1.1) Asosiy leucine fermuar (bZIP)

Transkripsiya omilini faollashtirish
- AATF
- 1
- 2
- 3
- 4
- 5
- 6
- 7
AP-1
- c-Fos
- FOSB
- FOSL1
- FOSL2
- JDP2
- c-iyun
- JUNB
- JunD
BACH
- 1
- 2
BATF
BLZF1
C / EBP
- a
- β
- γ
- δ
- ε
- ζ
CREB
- 1
- 3
- L1
CREM
JB
DDIT3
GABPA
GCN4
HLF
MAF
- B
- F
- G
- K
NFE
- 2
- L1
- L2
- L3
NFIL3
NRL
NRF
- 1
- 2
- 3
XBP1

(1.2) Asosiy spiral-halqa-spiral (bHLH)

bHLH-PAS	AhR ARNTL ARNTL ARNTL2 SAAT HIF 1A EPAS1 3A NPAS 1 2 3 SIM karta 1 2
ATOH1 AHRR ARNT ASCL1 BHLH 2 3 9 FIGLA QO'L 1 2 GES 1 2 3 4 5 6 7 HEY 1 2 L ID 1 2 3 4 LYL1 MESP2 MXD4 MYCL1 MYCN Myogenik tartibga soluvchi omillar MyoD Myogenin MYF5 MYF6 Neyrogeninlar 1 2 3 NeuroD 1 2 OLIG 1 2 Pho4 Skleraksis TAL 1 2 Twist

(1.3) bHLH-ZIP

(1.4) NF-1

NFI
- A
- B
- C
- X
SMAD
- R-SMAD
  - 1
  - 2
  - 3
  - 5
  - 9
- I-SMAD
  - 6
  - 7
- 4)

(1.5) RF-X

RFX
- 1
- 2
- 3
- 4
- 5
- 6
- ANK

(1.6) Asosiy spiral-span-spiral (bHSH)

AP-2
- a
- β
- γ
- δ
- ε

(2) Sink barmog'i DNK bilan bog'laydigan domenlar

(2.1) Yadro retseptorlari (Cys.)₄)

1-oila	Qalqonsimon bez gormoni a β MOSHINA FXR LXR a β PPAR a β / δ γ PXR RAR a β γ ROR a β γ Rev-ErbA a β VDR
2. kichik oila	COUP-TF (Men II Quloq-2 HNF4 a γ PNR RXR a β γ Moyak retseptorlari 2 4 TLX
3. kichik oila	Steroid gormoni Androgen Estrogen a β Glyukokortikoid Mineralokortikoid Progesteron Estrogen bilan bog'liq a β γ
4. kichik oila	NUR NGFIB NOR1 NURR1
5. kichik oila	LRH-1 SF1
6. kichik oila	GCNF
0	DAX1 SHP

(2.2) Boshqa dasturlar₄

GATA
- 1
- 2
- 3
- 4
- 5
- 6
MTA
- 1
- 2
- 3
TRPS1

(2.3) Cys₂Uning₂

Umumiy transkripsiya omillari
- TFIIA
- TFIIB
- TFIID
- TFIIE
  - 1
  - 2
- TFIIF
- 1
- 2
  - TFIIH
  - 1
  - 2
  - 4
  - 2I
  - 3A
  - 3C1
  - 3C2

ATBF1
BCL
- 6
- 11A
- 11B
CTCF
E4F1
EGR
- 1
- 2
- 3
- 4
ERV3
GFI1
GLI-Kryppel oila
- 1
- 2
- 3
- Dam olish
- S1
- S2
- YY1
HIC
- 1
- 2
HIVEP
- 1
- 2
- 3
IKZF
- 1
- 2
- 3
ILF
- 2
- 3
KLF
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 15
- 17
MTF1
MYT1
OSR1
PRDM9
SALL
- 1
- 2
- 3
- 4
SP
- 1
- 2
- 4
- 7
- 8
TSHZ3
WT1
Zbtb7
- 7A
- 7B
ZBTB
- 11
- 16
- 17
- 20
- 32
- 33
- 40
sink barmog'i
- 3
- 7
- 9
- 10
- 19
- 22
- 24
- 33B
- 34
- 35
- 41
- 43
- 44
- 51
- 74
- 143
- 146
- 148
- 165
- 202
- 217
- 219
- 238
- 239
- 259
- 267
- 268
- 281
- 295
- 300
- 318
- 330
- 346
- 350
- 365
- 366
- 384
- 423
- 451
- 452
- 471
- 593
- 638
- 644
- 649
- 655
- 804A

(2.4) Cys₆

HIVEP1

(2.5) O'zgaruvchan kompozitsiya

AIRE
DIDO1
GRLF1
ING
- 1
- 2
- 4
JARID
- 1A
- 1B
- 1C
- 1D
- 2
JMJD1B

(2.6) WRKY

WRKY

(3) Spiral-burilish-spiral domenlar

(3.1) Homeodomain

protoHOX	ParaHox Gsx 1 2 Xlox PDX1 CDx 1 2 4 kengaytirilgan Hox: Evx1 Evx2 MEOX1 MEOX2 Uy qutisi A1 A2 A3 A4 A5 A7 A9 A10 A11 A13 B1 B2 B3 B4 B5 B6 B7 B8 B9 B13 C4 C5 C6 C8 C9 C10 C11 C12 C13 D1 D3 D4 D8 D9 D10 D11 D12 D13 GBX1 GBX2 MNX1
metaHOX	BARHL1 BARHL2 BARX1 BARX2 BSX JB 1 2 DLX 1 2 3 4 5 6 EMX 1 2 EN 1 2 HHEX HLX LBX1 LBX2 MSX 1 2 NANOG NKX 2-1 2-2 2-3 2-5 3-1 3-2 HMX1 HMX2 HMX3 6-1 6-2 NATO TLX1 TLX2 TLX3 VAX1 VAX2
boshqa	ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX IRX 1 2 3 4 5 6 MKX LMX 1A 1B NOBOX Ertak MEIS 1 2 ATB 1 2 3 PKNOX 1 2 PHF 1 3 6 8 10 16 17 20 21A PHOX 2A 2B PITX 1 2 3 POU domeni PIT-1 BRN-3: A B C Oktamer transkripsiyasi koeffitsienti: 1 2 3/4 6 7 11 OTX 1 2 SATB2 SHOX2 Olti 1 2 3 4 5 ZEB 1 2

(3.2) bog'langan quti

PAX
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
PRRX
- 1
- 2
RAX

(3.3) Vilka boshi / qanotli spiral

E2F
- 1
- 2
- 3
- 4
- 5
FOX oqsillari
- A1
- A2
- A3
- C1
- C2
- D3
- D4
- E1
- E3
- F1
- G1
- H1
- I1
- J1
- J2
- K1
- K2
- L2
- M1
- N1
- N3
- O1
- O3
- O4
- P1
- P2
- P3
- P4

(3.4) Issiqlik zarbasi omillari

HSF
- 1
- 2
- 4

(3.5) Triptofan klasterlari

ELF
- 2
- 4
- 5
EGF
ELK
- 1
- 3
- 4
ERF
ETS
- 1
- 2
- ERG
- SPIB
ETV
- 1
- 4
- 5
- 6
FLI1
Interferonni tartibga solish omillari
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
MYB
MYBL2

(3.6) TEA domeni

transkripsiya kuchaytiruvchi omil
- 1
- 2
- 3
- 4

(4) Kichik yivli kontaktlarga ega b-iskala omillari

(4.1) Rel homologiyasi mintaqasi	NF-DB NFKB1 NFKB2 REL RELA RELB NFAT C1 C2 C3 C4 5
(4.2) STAT	STAT 1 2 3 4 5 6
(4.3) p53	p53 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF TP63
(4.4) MADS qutisi	Mef2 A B C D. SRF
(4.6) TATA bilan bog'lovchi oqsillar	TBP TBPL1
(4.7) Yuqori harakatchanlik guruhi	BBX HMGB 1 2 3 4 HMGN 1 2 3 4 HNF 1A 1B SOX 1 2 3 4 5 6 8 9 10 11 12 13 14 15 18 21 SRY SSRP1 TCF / LEF TCF 1 3 4 LEF1 TOX 1 2 3 4
(4.9) Grainyhead	TFCP2
(4.10) Sovuq zarba beruvchi domen	CSDA YBX1
(4.11) Runt	CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1

(0) Boshqa transkripsiya omillari

(0,2) HMGI (Y)	HMGA 1 2 HBP1
(0.3) Cho'ntak domeni	Rb RBL1 RBL2
(0.5) AP-2/EREBPbog'liq omillar	Apetala 2 EREBP B3
(0,6) Turli xil	ARID 1A 1B 2 3A 3B 4A CAP IFI 16 35 MLL 2 3 T1 MNDA NFY A B C Rho/Sigma

Shuningdek qarang transkripsiya faktori / yadro regulyatorining kamchiliklari

TGFβ retseptorlari superfamily modulyatorlar

ALK1 (ACVRL1)	Agonistlar: Aktivin (A, B, AB) Avotermin BMP (10) Cetermin GDF (2 (BMP9)) TGFβ (1, 2, 3) Antikorlar: Ascrinvacumab Kinaz inhibitörleri: K-02288 ML-347 (LDN-193719, VU0469381) Aldangan retseptorlari: Dalantertsept Boshqa inhibitörler: Disitertid
ALK2 (ACVR1A)	Agonistlar: Aktivin (A, B, AB) AMH (MIS) Avotermin BMP (5, 6, 7, 8A, 8B) Eptotermin alfa TGFβ (1, 2, 3) Kinaz inhibitörleri: DMH-1 DMH-2 Dorsomorfin (BML-275) K-02288 ML-347 (LDN-193719, VU0469381)
ALK3 (BMPR1A)	Agonistlar: AMH (MIS) BMP (2, 4, 5, 6, 7, 8A, 8B) Dibotermin alfa Eptotermin alfa Kinaz inhibitörleri: DMH-2 Dorsomorfin (BML-275) K-02288
ALK4 (ACVR1B)	Agonistlar: Aktivin (A, B, AB) GDF (1, 3, 11 (BMP11)) Myostatin (GDF8) Nodal Antagonistlar: Inhibin (A, B) Chap (1, 2) Kinaz inhibitörleri: 83-01 SB-431542 SB-505124
ALK5 (TGFβR1)	Agonistlar: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antikorlar: Fresolimumab Lerdelimumab Metelimumab Kinaz inhibitörleri: 83-01 D-4476 GW-788388 LY-364947 LY-2109761 Galunisertib (LY-2157299) R-268712 RepSox (E-616452, SJN-2511) SB-431542 SB-505124 SB-525334 SD-208
ALK6 (BMPR1B)	Agonistlar: BMP (2, 4, 5, 6, 7, 8A, 8B, 15 (GDF9B)) Dibotermin alfa Eptotermin alfa GDF (5 (BMP14), 6 (BMP13), 7 (BMP12), 9, 15) Radotermin Kinaz inhibitörleri: DMH-2 Dorsomorfin (BML-275) K-02288
ALK7 (ACVR1C)	Agonistlar: GDF (1, 3, 11 (BMP11)) Nodal Antagonistlar: Chap (1, 2) Kinaz inhibitörleri: 83-01 SB-431542 SB-505124

TGFβR2	Agonistlar: Avotermin GDF (10 (BMP3B)) TGFβ (1, 2, 3) Antikorlar: Fresolimumab Lerdelimumab Metelimumab Kinaz inhibitörleri: DMH-2 LY-364947
BMPR2	Agonistlar: BMP (2, 4, 6, 7, 10) Dibotermin alfa Eptotermin alfa GDF (2 (BMP9), 5 (BMP14), 6 (BMP13), 7 (BMP12)) Radotermin Antagonistlar: Inhibin (A, B)
ACVR2A (ACVR2)	Agonistlar: Aktivin (A, B, AB) BMP (2, 4, 5, 6, 7, 8A, 8B, 15 (GDF9B)) Dibotermin alfa Eptotermin alfa GDF (1, 3, 5 (BMP14), 6 (BMP13), 7 (BMP12), 9, 11 (BMP11), 15) Myostatin (GDF8) Nodal Radotermin Antagonistlar: Inhibin (A, B) Chap (1, 2) Aldangan retseptorlari: Sotatercept
ACVR2B	Agonistlar: Aktivin (A, B, AB) BMP (2, 4, 6, 7) Dibotermin alfa Eptotermin alfa GDF (1, 3, 5 (BMP14), 6 (BMP13), 7 (BMP12)) Myostatin (GDF8) Nodal Osteogenin (BMP3, BMP3A) Radotermin Antagonistlar: Inhibin (A, B) Chap (1, 2) Aldangan retseptorlari: Ramatercept
AMHR2 (AMHR)	Agonistlar: AMH (MIS)

TGFβR3 (b-glikan)	Ligandlar: Avotermin Inhibin (A, B) TGFβ (1, 2, 3)

Saralanmagan

Endogen antagonistlar / inhibitorlar: BAMBI
Cerberus (CER1)
Chordin
DAN (PARN)
Decorin
Follistatin
Gremlin (Drm)
LTBP1
Noggin
TGIF
Trombospondin 1 (THBS1)
Tomoregulin 1

Antikorlar: Stamulumab (myostatinga qarshi)
TRC105 (endoglinga qarshi)

Boshqalar: Endoglin

Shuningdek qarang: Retseptor / signalizatsiya modulyatorlari; Signal peptid / oqsil retseptorlari modulyatorlari; O'sish omili retseptorlari modulyatorlari; Sitokin retseptorlari modulyatorlari

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