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Ibodutant
Klinik ma'lumotlar
Boshqa ismlar	6-metil-N-[1-[[(2R) -1 - [[1- (oksan-4-ilmetil) piperidin-4-yl] metilamino] -1-okso-3-fenilpropan-2-yl] karbamoil] siklopentil] -1-benzotiofen-2-karboksamid
Marshrutlari; ma'muriyat	Og'zaki
ATC kodi	yo'q;
Identifikatorlar
	IUPAC nomi Na - [(1 - {[(6-metil-1-benzotien-2-il) karbonil] amino} siklopentil) karbonil] -N- {[1- (tetrahidro-2)H-piran-4-ilmetil) piperidin-4-il] metil} -D.-fenilalaninamid;
CAS raqami	522664-63-7 ;
PubChem CID	11527495;
IUPHAR / BPS	2117;
ChemSpider	9702281 ;
UNII	1H7RSQ28BJ;
CompTox boshqaruv paneli (EPA)	DTXSID20966639 ;
Kimyoviy va fizik ma'lumotlar
Formula	C37H48N4O4S
Molyar massa	644.88 g · mol−1
3D model (JSmol)	Interaktiv rasm;
	Jilmayganlar CC1 = CC2 = C (C = C1) C = C (S2) C (= O) NC3 (CCCC3) C (= O) NC (CC4 = CC = CC = C4) C (= O) NCC5CCN (CC5) CC6CCOCC6;
	InChI InChI = 1S / C37H48N4O4S / c1-26-9-10-30-23-33 (46-32 (30) 21-26) 35 (43) 40-37 (15-5-6-16-37) 36 ( 44) 39-31 (22-27-7-3-2-4-8-27) 34 (42) 38-24-28-11-17-41 (18-12-28) 25-29-13- 19-45-20-14-29 / h2-4,7-10,21,23,28-29,31H, 5-6,11-20,22,24-25H2,1H3, (H, 38,42 ) (H, 39,44) (H, 40,43) / t31- / m1 / s1 ; Kalit: YQYSVMKCMIUCHY-WJOKGBTCSA-N ;
	(bu nima?) (tasdiqlash)

Ibodutant

Ibodutant uchun nomzod giyohvand moddalar edi irritabiy ichak sindromi diareya, The tomonidan ishlab chiqilgan Menarini Guruh. 2015 yil mart oyidan boshlab^[yangilash], u ko'p markazli er-xotin ko'r samaradorligi klinikasini o'tkazdi o'rganish. Ibodutant tanlab blokirovka qiladi taxikinin retseptorlari NK₂, blokirovka bilan deyarli nanoSIMdamolar konsentratsiyalar. Evropada 2-bosqich sinovi (IRIS-2 sinovi) 2012 yil may oyida ijobiy natijalar bilan yakunlandi. NAK-06 tadqiqotining past natijalari va salbiy natijalari tufayli 52 haftalik 3-bosqich ishi 2015 yildan boshlab to'xtatildi.^[1]

Shuningdek qarang

Adabiyotlar

^ "Klinik tadqiqotlar uchun ma'lumotlar bazasi". Menarini guruhi. Olingan 11 mart 2015.

Qo'shimcha o'qish

Spreitzer H (2008 yil 26-may). "Neue Wirkstoffe - Ibodutant". Österreichische Apothekerzeitung (nemis tilida) (11/2008): 541.
Giuliani S, Altamura M, Maggi CA. "Ibodutant. Tachikinin NK₂ retseptorlari antagonisti, irritabiy ichak sindromini davolash ". Kelajak giyohvand moddalari. 33 (2): 111–115.

Bu dori ga tegishli maqola asab tizimi a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.

[1] "Klinik tadqiqotlar uchun ma'lumotlar bazasi". Menarini guruhi. Olingan 11 mart 2015.

[1]

v t e Neyrokinin retseptorlari modulyatorlar
NK₁	Agonistlar: P moddasi Antagonistlar: Yaxshi Befetupitant Burapitant Kasopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743,310 L-758,298 Lanepitant LY-306740 Maropitant Netupitant NKP-608 Nolpitantium susayadi Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant
NK₂	Agonistlar: Neyrokinin A Antagonistlar: GR-159897 Ibodutant Nepadutant Saredutant
NK₃	Agonistlar: Neyrokinin B Senktayd Antagonistlar: Fezolinetant (ESN-364) Osanetant (SR-142,801) Pavinetant (MLE-4901, AZD-2624, AZD-4901) SB-218,795 SB-222,200 Taletant (SB-223,412)
Shuningdek qarang: Retseptor / signalizatsiya modulyatorlari • Signal peptid / oqsil retseptorlari modulyatorlari

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Klinik ma'lumotlar

Boshqa ismlar	6-metil-N-[1-[[(2R) -1 - [[1- (oksan-4-ilmetil) piperidin-4-yl] metilamino] -1-okso-3-fenilpropan-2-yl] karbamoil] siklopentil] -1-benzotiofen-2-karboksamid
Marshrutlari ma'muriyat	Og'zaki
ATC kodi	yo'q
Identifikatorlar
IUPAC nomi Na - [(1 - {[(6-metil-1-benzotien-2-il) karbonil] amino} siklopentil) karbonil] -N- {[1- (tetrahidro-2)H-piran-4-ilmetil) piperidin-4-il] metil} -D.-fenilalaninamid
CAS raqami	522664-63-7^Y
PubChem CID	11527495
IUPHAR / BPS	2117
ChemSpider	9702281^N
UNII	1H7RSQ28BJ
CompTox boshqaruv paneli (EPA)	DTXSID20966639
Kimyoviy va fizik ma'lumotlar
Formula	C₃₇H₄₈N₄O₄S
Molyar massa	644.88 g · mol⁻¹
3D model (JSmol)	Interaktiv rasm
Jilmayganlar CC1 = CC2 = C (C = C1) C = C (S2) C (= O) NC3 (CCCC3) C (= O) NC (CC4 = CC = CC = C4) C (= O) NCC5CCN (CC5) CC6CCOCC6
InChI InChI = 1S / C37H48N4O4S / c1-26-9-10-30-23-33 (46-32 (30) 21-26) 35 (43) 40-37 (15-5-6-16-37) 36 ( 44) 39-31 (22-27-7-3-2-4-8-27) 34 (42) 38-24-28-11-17-41 (18-12-28) 25-29-13- 19-45-20-14-29 / h2-4,7-10,21,23,28-29,31H, 5-6,11-20,22,24-25H2,1H3, (H, 38,42 ) (H, 39,44) (H, 40,43) / t31- / m1 / s1^N Kalit: YQYSVMKCMIUCHY-WJOKGBTCSA-N^N
^NY (bu nima?) (tasdiqlash)