WikiDer > Lergotril - Vikipediya

Lergotril
Identifikatorlar
	IUPAC nomi 2 - [(6aR,9S, 10aR) -5-xloro-7-metil-6,6a, 8,9,10,10a-geksahidro-4H-indolo [4,3-fg] kinolin-9-il] asetonitril;
CAS raqami	36945-03-6;
PubChem CID	6918447;
Kimyoviy va fizik ma'lumotlar
Formula	C17H18ClN3
Molyar massa	299.80 g · mol−1
3D model (JSmol)	Interaktiv rasm;
	Jilmayganlar CN1C [C @@ H] (C [C @ H] 2 [C @ H] 1CC3 = C (NC4 = CC = CC2 = C34) Cl) CC # N;
	InChI InChI = 1S / C17H18ClN3 / c1-21-9-10 (5-6-19) 7-12-11-3-2-4-14-16 (11) 13 (8-15 (12) 21) 17 ( 18) 20-14 / h2-4,10,12,15,20H, 5,7-9H2,1H3 / t10-, 12-, 15- / m1 / s1; Kalit: JKAHWGPTNVUTNB-IXPVHAAZSA-N;

Lergotrile - Wikipedia

Lergotril bu ergolin vazifasini bajaruvchi lotin dopamin retseptorlari agonist. U davolash uchun ishlab chiqilgan Parkinson kasalligi, lekin muvaffaqiyatsiz tugadi klinik sinovlar jigar toksikligi tufayli.^[1]^[2]

Adabiyotlar

^ Liberman AN, Gopinatan G, Estey E, Kupersmit M, Gudgold A, Goldstayn M (fevral 1979). "Parkinson kasalligida lergotril: keyingi tadqiqotlar". Nevrologiya. 29 (2): 267–72. doi:10.1212 / wnl.29.2.267. PMID 34808.
^ Cunningham KA, Callahan PM, Appel JB (1984 yil iyul). "Lergotrilning diskriminatsion rag'batlantiruvchi xususiyatlari". Farmakologiya va eksperimental terapiya jurnali. 230 (1): 47–52. PMID 6146709.

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v t e Ergolines
Liserjik kislota hosilalar	2-Bromo-LSD (BOL-148) Bromokriptin Kabergolin Dihidroergokornin Dihidroergokristin Dihidroergokriptin Dihidroergometrin (Dihidroergonovin, Dihidroergobazin) Dihidroergozin Dihidroergotamin Epikriptin Ergine (LSA; LA-111; Lizergamid) Ergokornin Ergistristin Ergokriptin Ergoloid (Dihidroergotoksin) Ergometrin (Ergonovine, Ergobasine) Ergometrinin Ergotamin Ergotoksin Ergovalin Lisurid LY-215,840 LSH Lisergik kislota Lizerjik kislota metil Ester Lisergol Mesulerjin Metergolin Meterjin (Metilergometrin, Metillergonovin, Metlergobazin) Metizergid Sergoleksol Sintometrin
Psychedelic lysergamidlar	1B-LSD 1cP-LSD 1P-ETH-LAD 1P-LSD AL-LAD ALD-52 BU-LAD CYP-LAD DAL DAM-57 ECPLA Ergonovin ETFELA ETH-LAD IP-LAD LAMPA LAE-32 LSD LPD-824 LSM-775 LSH LSD-Pip Liserjik kislota 2-butilamid Lizerjik kislota 2,4-dimetilazetidid Lizerjik kislota 3-Pentilamid Lizerjik kislota siklobutilamidi Lizerjik kislota siklopentilamidi Metillergonovin MIPLA MLD-41 PARGY-LAD PRO-LAD
Klavinalar	Agroklavin Elimoklavin Festuklavin Fumigaklavin A Fumigaklavin B Fumigaklavin S
Boshqalar ergolinlar	Ergolin Lergotril Pergolid
Tabiiy manbalar	Achnatherum robustum (Uyquchi o't) Klavitseps spp. (Ergot) Ertalab shon-sharaf: Argireya (Gavayi bolasi Woodrose), Ipomoea spp.(Morning Glory, Tlitliltzin, Badoh Negro), Rivea corymbosa (Coaxihuitl, Ololiúqui)

Identifikatorlar

IUPAC nomi 2 - [(6aR,9S, 10aR) -5-xloro-7-metil-6,6a, 8,9,10,10a-geksahidro-4H-indolo [4,3-fg] kinolin-9-il] asetonitril
CAS raqami	36945-03-6
PubChem CID	6918447
Kimyoviy va fizik ma'lumotlar
Formula	C₁₇H₁₈ClN₃
Molyar massa	299.80 g · mol⁻¹
3D model (JSmol)	Interaktiv rasm
Jilmayganlar CN1C [C @@ H] (C [C @ H] 2 [C @ H] 1CC3 = C (NC4 = CC = CC2 = C34) Cl) CC # N
InChI InChI = 1S / C17H18ClN3 / c1-21-9-10 (5-6-19) 7-12-11-3-2-4-14-16 (11) 13 (8-15 (12) 21) 17 ( 18) 20-14 / h2-4,10,12,15,20H, 5,7-9H2,1H3 / t10-, 12-, 15- / m1 / s1 Kalit: JKAHWGPTNVUTNB-IXPVHAAZSA-N