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Metatsiklin
Klinik ma'lumotlar
AHFS/Drugs.com	Giyohvand moddalarning xalqaro nomlari
ATC kodi	J01AA05 (JSSV) ;
Identifikatorlar
	IUPAC nomi (2Z,4S, 4aR,5S, 5aR, 12aS) -2- [amino (gidroksi) metilen] -4- (dimetilamino) -5,10,11,12a-tetrahidroksi-6-metilen-4a, 5a, 6,12a-tetrahidrotetracen-1,3,12 (2)H,4H,5H) - trion;
CAS raqami	914-00-1 ;
PubChem CID	54675785;
ChemSpider	10468596 ;
UNII	IR235I7C5P;
ChEMBL	ChEMBL249837 ;
NIAID ChemDB	001301;
CompTox boshqaruv paneli (EPA)	DTXSID2023272 ;
ECHA ma'lumot kartasi	100.011.834
Kimyoviy va fizik ma'lumotlar
Formula	C22H22N2O8
Molyar massa	442.424 g · mol−1
3D model (JSmol)	Interaktiv rasm;
	Jilmayganlar NC (= O) C = 3C (= O) [C @@] 4 (O) C ( O) = C2 C (= O) c1c (O) cccc1C (= C) [C @ H] 2 [ C @ H] (O) [C @ H] 4 [C @ H] (N (C) C) C = 3O;
	InChI InChI = 1S / C22H22N2O8 / c1-7-8-5-4-6-9 (25) 11 (8) 16 (26) 12-10 (7) 17 (27) 14-15 (24 (2) 3) 18 (28) 13 (21 (23) 31) 20 (30) 22 (14,32) 19 (12) 29 / h4-6,10,14-15,17,25,27-29,32H, 1H2, 2-3H3, (H2,23,31) / t10-, 14-, 15 +, 17 +, 22 + / m1 / s1 ; Kalit: MHIGBKBJSQVXNH-IWVLMIASSA-N ;
	(bu nima?) (tasdiqlash)

Metacycline

Metatsiklin a tetratsiklin antibiotiklari. U sifatida ishlatiladi kashshof sanoat sohasida sintez ning doksisiklin giklati.

Ning vazifasini bajarishi aniqlandi agonist insonning homiladorlik X retseptorlari ligandni bog'laydigan domen va undash uchun CYP3A4 ifoda in vitro.^[1]

Adabiyotlar

^ Shukla SJ, Sakamuru S, Xuang R, Moeller TA, Shinn P, Vanleer D, Auld DS, Ostin CP, Xia M (2011). "Homiladorlik X retseptorlarini faollashtiradigan klinik qo'llaniladigan dorilarni aniqlash" (PDF). Dori vositasi. Disposlar. 39 (1): 151–9. doi:10.1124 / dmd.110.035105. PMC 3014269. PMID 20966043.

Ushbu tizimli antibiotikbilan bog'liq maqola a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.

[pmid20966043-1] Shukla SJ, Sakamuru S, Xuang R, Moeller TA, Shinn P, Vanleer D, Auld DS, Ostin CP, Xia M (2011). "Homiladorlik X retseptorlarini faollashtiradigan klinik qo'llaniladigan dorilarni aniqlash" (PDF). Dori vositasi. Disposlar. 39 (1): 151–9. doi:10.1124 / dmd.110.035105. PMC 3014269. PMID 20966043.

[1]

v t e Ksenobiotikni sezuvchi retseptor modulyatorlar
MOSHINA	Agonistlar: 6,7-dimetilsületin Amiodaron Artemisinin Benfurakarb Karbamazepin Carvedilol Xlorpromazin Krizin CITCO Klotrimazol Siklofosfamid Kipermetrin DHEA (prasterone) Efavirenz Ellagik kislota Griseofulvin Metoksiklor Mifepriston Nefazodon Nevirapin Nikardipin Oktizator Permetrin Fenobarbital Fenitoin Pregnanedion (5β-dihidroprogesteron) Reserpine TCPOBOP Telmisartan Tolnaftat Troglitazon Valproik kislota Antagonistlar: 3,17β-Estradiol 3a-Androstanol 3a-Androstenol 3β-Androstanol 17-Androstanol AITC Etinilestradiol Meklizin Nigramide J Okaday kislotasi PK-11195 S-07662 T-0901317
PXR	Agonistlar: 17a-gidroksipregnenolon 17a-gidroksiprogesteron Δ⁴-Androstenedion Δ⁵-Androstenediol Δ⁵-Androstenedion AA-861 Allopregnanediol Allopregnanedion (5a-dihidroprogesteron) Allopregnanolon (brexanolon) Alfa-lipoy kislotasi Ambrisentan AMI-193 Amlodipin besilat Antimikotiklar Artemisinin Aurotioglyukoza Safro kislotalari Bitionol Bosentan Bumekain Kafetol Tsefaloridin Tsefradin Xlorpromazin Siglitazon Klindamitsin Klofenvinfos Xloroksin Klotrimazol Kolforsin Kortikosteron Siklofosfamid Siproteron asetat Demekoltsin Deksametazon DHEA (prasterone) DHEA-S (prasteron sulfat) Natriyni dibunatlash Diklazuril Dikloksatsillin Dimercaprol Dinalin Detsetaksel Kaltsiyni hujjatlashtiring Dodesilbenzensulfan kislotasi Dronabinol Droksidopa Eburnamonin Ekopipam Enzakamin Epothilone B Eritromitsin Famprofazon Fevantel Felodipin Fenbendazol Fentanil Flukloksatsillin Ftorometolon Griseofulvin Guggulsterone Haloprogin Xetatsillin kaliy Giperforin Hypericum perforatum (St John's wort) Indinavir sulfat Lasalotsid natriy Levotiroksin Linolenik kislota LOE-908 Loratadin Lovastatin Meklizin Metatsiklin Metilprednizolon Metyrapone Mevastatin Mifepriston Naftsillin Nikardipin Nikotin Nifedipin Nilvadipin Nisoldipin Norelgestromin Omeprazol Orlistat Oksatomid Paklitaksel Fenobarbital Piperin Plikamitsin Prednizolon Pregnandiol Pregnanedion (5β-dihidroprogesteron) Pregnanolon Pregnenolon Pregnenolon 16a-karbonitril Proadifen Progesteron Quingestrone Reserpine Teskari triiodotironin Rifampitsin Rifaximin Rimexolon Riodipin Ritonavir Simvastatin Sirolimus Spironolakton Spiroksatrin SR-12813 Suberoylanilid Sulfisoksazol Suramin Takrolimus Tenilidon Terconazol Testosteron izokaproat Tetratsiklin Tiamilal natriy Thiothixene Tonzoniyum bromidi Tianeptin Troglitazon Troleandomitsin Tropanil 3,5-dimetulbenzoat Zafirlukast Zeranol Antagonistlar: Ketokonazol Sesamin
Shuningdek qarang Retseptor / signalizatsiya modulyatorlari

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