WikiDer > Nurseotricin - Vikipediya

Nurseotricin
	; n = 1-4
Ismlar
	IUPAC nomi [(2R, 3S, 4R, 5R, 6R) -6 - [[(3aS, 7R, 7aS) -7-gidroksi-4-okso-1,3a, 5,6,7,7a-geksahidroimidazo [4,5 -c] piridin-2-yl] amino] -5 - [[(3S) -3,6-diaminohexanoyl] amino] -4-hydroxy-2- (hydroxymethyl) oxan-3-yl] karbamat
Identifikatorlar
CAS raqami	56089-12-4; 96736-11-7 (sulfat);
3D model (JSmol)	Interaktiv rasm;
ChEMBL	ChEMBL2334879;
PubChem CID	71720685;
	InChI InChI = 1S / C19H34N8O8 / c20-3-1-2-7 (21) 4-10 (30) 24-13-14 (31) 15 (35-18 (22) 33) 9 (6-28) 34- 17 (13) 27-19-25-11-8 (29) 5-23-16 (32) 12 (11) 26-19 / h7-9,11-15,17,28-29,31H, 1- 6,20-21H2, (H2,22,33) (H, 23,32) (H, 24,30) (H2,25,26,27) / t7-, 8 +, 9 +, 11 +, 12 -, 13 +, 14 +, 15 +, 17 + / m0 / s1 Kalit: NRAUADCLPJTGSF-ZPGVOIKOSA-N;
	Jilmayganlar C1 [C @ H] ([C @@ H] 2 [C @@ H] (C (= O) N1) N = C (N2) N [C @ H] 3 [C @@ H] ([C @H] ([C @@ H] ([C @ H] (O3) CO) OC (= O) N) O) NC (= O) C [C @ H] (CCCN) N) O;
Xususiyatlari
Kimyoviy formulalar	C19H34N8O8
Molyar massa	502.529 g · mol−1
Suvda eruvchanligi	~ 1 g / l
	Boshqacha ko'rsatilmagan hollar bundan mustasno, ulardagi materiallar uchun ma'lumotlar keltirilgan standart holat (25 ° C [77 ° F], 100 kPa da).
	Infobox ma'lumotnomalari

Nourseothricin - Wikipedia

Nurseotricin (NTC) a'zosi streptotricin- sinf aminoglikozid antibiotiklari tomonidan ishlab chiqarilgan Streptomitsiyalar turlari. Kimyoviy jihatdan NTC - bu streptotricin C, D, E va F birikmalarining aralashmasi.^[1] NTC inhibe qiladi oqsil sintezi noto'g'ri kodlashni keltirib chiqarish orqali. U sifatida ishlatiladi tanlov markeri organizmlarning keng doirasi, shu jumladan bakteriyalar, xamirturush, filamentli qo'ziqorinlarva o'simlik hujayralari. Tanlangan dori uchun kardinal xususiyatga ega bo'lgan ijobiy tanlangan hujayralarga salbiy ta'sir ko'rsatishi ma'lum emas.^[2]

NTC faolsizlantirilishi mumkin nourseotricin N-asetil transferaza (NAT) dan Streptomyces noursei, an ferment bu atsetilatlar ning beta-amino guruhi beta-lizin NTC qoldig'i.^[3] Shunday qilib NAT an vazifasini bajarishi mumkin antibiotiklarga qarshilik gen.

Xususiyatlari

NTC suvda yaxshi eriydi (~ 1 g / ml) va eritmada 4 yil davomida 2 yil davomida barqaror bo'ladi.^[4]

^ Nurseotricin
^ Kochupurakkal BS, Iglehart JD (2013). "Nurseotricin N-asetil transferaza: sutemizuvchilar hujayralari uchun ijobiy tanlov markeri". PLOS ONE. 8 (7): e68509. doi:10.1371 / journal.pone.0068509. PMC 3701686. PMID 23861913.
^ Krügel H, Fidler G, Smit S, Baumberg S (1993). "Streptomyces noursei dan nurseotricin asetiltransferaza-kodlovchi gen nat1 ning ketma-ketligi va transkripsiyaviy tahlili". Gen. 127 (1): 127–31. doi:10.1016 / 0378-1119 (93) 90627-f. PMID 8486278.
^ NTC xususiyatlari, Jena Bioscience

Ushbu tizimli antibiotikbilan bog'liq maqola a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.

Ismlar
n = 1-4
IUPAC nomi [(2R, 3S, 4R, 5R, 6R) -6 - [[(3aS, 7R, 7aS) -7-gidroksi-4-okso-1,3a, 5,6,7,7a-geksahidroimidazo [4,5 -c] piridin-2-yl] amino] -5 - [[(3S) -3,6-diaminohexanoyl] amino] -4-hydroxy-2- (hydroxymethyl) oxan-3-yl] karbamat
Identifikatorlar
CAS raqami	56089-12-4 96736-11-7 (sulfat)
3D model (JSmol)	Interaktiv rasm
ChEMBL	ChEMBL2334879
PubChem CID	71720685
InChI InChI = 1S / C19H34N8O8 / c20-3-1-2-7 (21) 4-10 (30) 24-13-14 (31) 15 (35-18 (22) 33) 9 (6-28) 34- 17 (13) 27-19-25-11-8 (29) 5-23-16 (32) 12 (11) 26-19 / h7-9,11-15,17,28-29,31H, 1- 6,20-21H2, (H2,22,33) (H, 23,32) (H, 24,30) (H2,25,26,27) / t7-, 8 +, 9 +, 11 +, 12 -, 13 +, 14 +, 15 +, 17 + / m0 / s1 Kalit: NRAUADCLPJTGSF-ZPGVOIKOSA-N
Jilmayganlar C1 [C @ H] ([C @@ H] 2 [C @@ H] (C (= O) N1) N = C (N2) N [C @ H] 3 [C @@ H] ([C @H] ([C @@ H] ([C @ H] (O3) CO) OC (= O) N) O) NC (= O) C [C @ H] (CCCN) N) O
Xususiyatlari
Kimyoviy formulalar	C₁₉H₃₄N₈O₈
Molyar massa	502.529 g · mol⁻¹
Suvda eruvchanligi	~ 1 g / l
Boshqacha ko'rsatilmagan hollar bundan mustasno, ulardagi materiallar uchun ma'lumotlar keltirilgan standart holat (25 ° C [77 ° F], 100 kPa da).
Infobox ma'lumotnomalari