WikiDer > Propizepin

Propizepin
Klinik ma'lumotlar
Savdo nomlari	Depressin, Vagran
Marshrutlari; ma'muriyat	Og'zaki
ATC kodi	yo'q;
Huquqiy holat
Huquqiy holat	Umuman olganda: ℞ (faqat retsept bo'yicha);
Identifikatorlar
	IUPAC nomi 6- (2-dimetilaminopropil) -11H-pirido [3,2-c] [1,5] benzodiazepin-5-one;
CAS raqami	10321-12-7 ; 14559-79-6 (gidroxlorid);
PubChem CID	112029;
ChemSpider	100443;
UNII	09B57945V9;
ChEMBL	ChEMBL2104749;
ECHA ma'lumot kartasi	100.030.629
Kimyoviy va fizik ma'lumotlar
Formula	C17H20N4O
Molyar massa	296.374 g · mol−1

Propizepine

Propizepin (tovar nomlari Depressin, Vagran) a trisiklik antidepressant (TCA) da ishlatilgan Frantsiya davolash uchun depressiya 1970-yillarda kiritilgan.^[1]^[2]^[3]^[4]

Sintez

Propizepin sintezi:^[5]^[6]

2-xloronikotin kislotasining kondensatsiyasi (2) bilan o-fenilendiamin (1) to'g'ridan-to'g'ri trisiklikka olib keladi laktam (3) Garchi reaksiya amid hosil bo'lishi va xlorning nukleofil aromatik siljishini o'z ichiga olsa ham, bu bosqichlarning tartibi ma'lum emas. Agar davolanish natijasida olingan anionning alkillanishi 3 1-xloro-2-dimetilaminopropan bilan (4) antidepressant propizepin birikmasini beradi (5).

Ushbu ketma-ketlikning so'nggi bosqichida bunday alkillanishlarning ko'pincha aziridinium ioni. Anionning aziridinyum halqasining ikkilamchi yoki uchinchi uglerodiga hujumi turli xil mahsulotlarga olib keladi. Ushbu muammoni keng ko'lamli tekshirish (masalan, Prometazin, etopropazinva hokazo) shuni ko'rsatdiki, ikkilamchi uglerodga qarshi hujum odatda mahsulot ustunlik qiladi.

Bu aytmoqchi bo'lgan narsa, xloramin aslida 1-dimetilamino-2-xloro-propan bo'lsa ham, garchi u hali ham mahsulotlarning aralashmasi bo'lishi mumkin bo'lsa ham, asosan "izo" mahsuloti emas, balki yuqoridagi kabi reaktsiya mahsulotini oladi.

Adabiyotlar

^ Shveytsariya farmatsevtika jamiyati (2000). Index Nominum 2000: Xalqaro dori-darmonlar katalogi (CD-ROM bilan kitob). Boka Raton: Medpharm ilmiy nashrlari. p. 888. ISBN 3-88763-075-0.
^ Triggle DJ (1996). Farmakologik agentliklar lug'ati. Boka Raton: Chapman & Hall / CRC. p. 1680. ISBN 0-412-46630-9.
^ Myuller NF, Dessing RP (1997). Evropaning giyohvand moddalar indeksi. Evropa klinik farmatsiya jamiyati. 33. CRC Press. p. 1339. ISBN 3-7692-2114-1.
^ Dereux JF (1976). "[Vagran 50: situatsion antidepressant]". Semaine des Hopitaux. Terapevtik davolash (frantsuz tilida). 52 (7–8): 385–8. PMID 996559.
^ Hoffman C, Faure A (1966). "Réaction de l'acide chloro-2-nikotinique". Buqa. Soc. Chim. Fr. 7: 2316.
^ NL 6600065, Laboratoriyalarga tayinlangan, 1966 yilda chiqarilgan. U.P.S.A.

[isbn3-88763-075-0-1] Shveytsariya farmatsevtika jamiyati (2000). Index Nominum 2000: Xalqaro dori-darmonlar katalogi (CD-ROM bilan kitob). Boka Raton: Medpharm ilmiy nashrlari. p. 888. ISBN 3-88763-075-0.

[isbn0-412-46630-9-2] Triggle DJ (1996). Farmakologik agentliklar lug'ati. Boka Raton: Chapman & Hall / CRC. p. 1680. ISBN 0-412-46630-9.

[isbn3-76922-114-1-3] Myuller NF, Dessing RP (1997). Evropaning giyohvand moddalar indeksi. Evropa klinik farmatsiya jamiyati. 33. CRC Press. p. 1339. ISBN 3-7692-2114-1.

[pmid996559-4] Dereux JF (1976). "[Vagran 50: situatsion antidepressant]". Semaine des Hopitaux. Terapevtik davolash (frantsuz tilida). 52 (7–8): 385–8. PMID 996559.

[5] Hoffman C, Faure A (1966). "Réaction de l'acide chloro-2-nikotinique". Buqa. Soc. Chim. Fr. 7: 2316.

[6] NL 6600065, Laboratoriyalarga tayinlangan, 1966 yilda chiqarilgan. U.P.S.A.

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v t e Trisikliklar
Sinflar	Akridin Antrasen Dibenzazepin Dibenzotsiklohepten Dibenzodiazepin Dibenzotiazepin Dibenzotiepin Dibenzoksazepin Dibenzoksepin Fenotiazin Piridazinobenzoksazin Piridinobenzodiazepin Tioksanten
Antidepressantlar (TCAlar va TeCA)	7-OH-Amoksapin Amezepine Amineptin Amitriptilin Amitriptilinoksid Amoksapin Aptazapin Azepindol Azipramin Batelapin Butriptilin Sianopramin Tsiklazindol Tsiklopramin Sidoksepin Klomipramin Kotriptilin Siyanotiyepin Demeksiptilin Depramin (balipramin) Desipramin (desmetilimipramin) Desmetilklomipramin Desmetiltrimipramin Dibenzepin Dimetakrin Dozulepin (dotiepin) Doksepin Enprazepin Esmirtazapin Fantridon Fluotrasen Gepzidin Gomopipramol Imipramin Imipraminoksid Intriptilin Iprindol Ketipramin Litrasen Lofepramin Losindol Loksapin Maprotilin Mariptilin Mazindol Melitrasen Metapramin Mezepin Mianserin Mirtazapin Monometakrin Naranol Nitroksazepin Norbutriptilin Nordoksepin Northiaden (nordosulepin) Nortriptilin (noramitriptilin) Noksiptilin Octriptilin Opipramol Oksaprotilin Pipofezin Pirandamin Propizepin Protriptilin Kinupramin Setiptilin (teciptiline) Spiroksepin Tandamin Tampramin Tianeptin Tienopramin Trimipramin
Antihistaminiklar	Azatadin Bisulepin Klobenzepam Siproheptadin Dacemazine Deptropin Desloratadin Epinastin Etimemazin Fenetazin Gidroksietilprometazin Izoprometazin Izotipendil Ketotifen Latrepirdin Loratadin Mebhidrolin Mequitazin Metdilazin Olopatadin Oksomemazin Fenindamin Pimeteksen Prometazin Propiomazin Rupatadin Tiazinamium
Antipsikotiklar	Asetofenazin Alimemazin Amoksapin Asenapin Butaklamol Butaperazin Karfenazin (karfenazin) Karpipramin Xlorpromazin Xlorprotixen Tsiklindol Citatepin Klokapramin Klomakran Klorotepin Clotiapine Klozapin Siyanotepin Dlotlotepin Dokloksitepin Erizepin Flukindol Flumezapin Fluotrasen Flupentiksol Flüfenazin Gevotrolin Gomopipramol Izofloksitepin Levomepromazin / Metotrimeprazin Loksapin Lurasidon Maroksepin Meperatiyepin Mesoridazin Metiapin Metitepin Metoksepin Mosapramin Naranol Oktometotepin Olanzapin Oksiklotepin Oksiprotepin Pentiapin Peraditiyepin Perathiepin Perazin Perfenazin Periciazin Pinoksepin Piperatsetazin Pipotiazin Pikindon Proxlorperazin Promazin Protipendil Ketiapin Savoksepin / sipazoksapin Sulforidazin Tenilapin Tietilperazin Tiyopropazat Tioridazin Thiothixene Tilozepin Traboksopin Trifluoperazin Triflupromazin Triflutepin Zotepin Zuklopentiksol
Antikonvulsanlar	Karbamazepin Dizosilpin Eslikarbazepin Eslikarbazepin asetat Etazepin Likarbazepin Okskarbazepin Oksitriptilin Rispenzepin
Boshqalar	Adozopin Aminopromazin Atiprosin Beloksepin Benzoktamin Carvedilol Sidoksepin Siklobenzaprin Damotepin Darenzepin Elanzepin Fluradolin Metilen ko'k Monatepil Nuvenzepin Oksetoron Perlapin P7C3 Pinadolin Pirenzepin Pirolat Pitrazepin Pizotifen Profenamin Serazapin Siltenzepin Telenzepin Tipindol Tropatepin Zolenzepin

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Klinik ma'lumotlar

Savdo nomlari	Depressin, Vagran
Marshrutlari ma'muriyat	Og'zaki
ATC kodi	yo'q
Huquqiy holat
Huquqiy holat	Umuman olganda: ℞ (faqat retsept bo'yicha)
Identifikatorlar
IUPAC nomi 6- (2-dimetilaminopropil) -11H-pirido [3,2-c] [1,5] benzodiazepin-5-one
CAS raqami	10321-12-7 14559-79-6 (gidroxlorid)
PubChem CID	112029
ChemSpider	100443
UNII	09B57945V9
ChEMBL	ChEMBL2104749
ECHA ma'lumot kartasi	100.030.629
Kimyoviy va fizik ma'lumotlar
Formula	C₁₇H₂₀N₄O
Molyar massa	296.374 g · mol⁻¹