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Remikiren
Klinik ma'lumotlar
ATC kodi	C09XA01 (JSSV) ;
Huquqiy holat
Huquqiy holat	Tergov;
Identifikatorlar
	IUPAC nomi (2S)-2-[(2R) -2-benzil-3- (2-metilpropan-2-sulfanil) propanamido] -N-[(2R,3S,4R) -1-sikloheksil-4-siklopropil-3,4-dihidroksibutan-2-yl] -3- (1H-imidazol-4-il) propanamid;
CAS raqami	126222-34-2 ;
PubChem CID	6324659;
DrugBank	DB00212 ;
ChemSpider	4884377 ;
UNII	LC7FBL96A4;
KEGG	D09038 ;
ChEBI	CHEBI: 8803;
ChEMBL	ChEMBL31601 ;
CompTox boshqaruv paneli (EPA)	DTXSID60155121 ;
Kimyoviy va fizik ma'lumotlar
Formula	C33H50N4O6S
Molyar massa	630.85 g · mol−1
3D model (JSmol)	Interaktiv rasm;
	Jilmayganlar O = S (= O) (C (C) (C) C) C [C @ H] (C (= O) N [C @ H] (C (= O) N [C @@ H) (CC1CCCCC1 ) [C @@ H] (O) [C @@ H] (O) C2CC2) Cc3cnc [nH] 3) Cc4ccccc4;
	InChI InChI = 1S / C33H50N4O6S / c1-33 (2,3) 44 (42,43) 20-25 (16-22-10-6-4-7-11-22) 31 (40) 37-28 (18-) 26-19-34-21-35-26) 32 (41) 36-27 (17-23-12-8-5-9-13-23) 30 (39) 29 (38) 24-14-15- 24 / h4,6-7,10-11,19,21,23-25,27-30,38-39H, 5,8-9,12-18,20H2,1-3H3, (H, 34,35) ) (H, 36,41) (H, 37,40) / t25-, 27 +, 28 +, 29 +, 30- / m1 / s1 ; Kalit: UXIGZRQVLGFTOU-VQXQMPIVSA-N ;
	(tasdiqlash)

Remikiren

Remikiren a renin inhibitori davolash uchun ishlab chiqilmoqda gipertoniya (yuqori qon bosimi). Bu birinchi tomonidan ishlab chiqilgan Hoffmann – La-Rosh 1996 yilda.^[1]

Adabiyotlar

^ Rixter WF, Whitby BR, Chou RC (1996). "Laboratoriya hayvonlarida remikiren, odam reninining kuchli og'zaki faol inhibitori". Ksenobiotika. 26 (3): 243–54. doi:10.3109/00498259609046705. PMID 8730917.

Bu dori ga tegishli maqola yurak-qon tomir tizimi a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.

v t e Gipertenziv dorilar bo'yicha harakat qilish renin-angiotensin tizimi (C09)
ACE inhibitörleri ("-pril")	Sulfhidril o'z ichiga oladi: Captopril Rentiapril Zofenopril Dikarboksilat o'z ichiga oladi: Enalapril^# Benazepril Silazapril Delapril Imidapril Lisinopril (+ HCT) Moeksipril Perindopril (+ indapamid) Quinapril (+ HCT) Ramipril Spirapril Temokapril Trandolapril Fosfonat o'z ichiga oladi: Ceronapril Fosinopril (+ HCT) Boshqa / guruhlanmagan: Alatsepril
AIIRAlar ("-sartan")	Azilsartan Kandesartan Eprosartan Fimasartan Irbesartan (+ HCT) Losartan (+ HCT) Olmesartan (+ amlodipin, + amlodipin va HCT) Tasosartan^§ Telmisartan (+ amlodipin, + HCT) Valsartan (+ amlodipin, + HCT)
Renin inhibitörleri ("-kiren")	Aliskiren (+ amlodipin, + HCT, + amlodipin va HCT) Remikiren^§
Ikki tomonlama ACE/NEP inhibitörler	Gemopatrilat Ilepatril Omapatrilat Sampatrilat
Neprilysin inhibitörler	Sakubitril (+ valsartan)
^#JSST-EM ^‡Olingan bozordan Klinik sinovlar: ^†III bosqich ^§Hech qachon III bosqichga

v t e Anjiyotensin retseptorlari modulyatorlar
ATR	Agonistlar: Angiotensin II Angiotensin III Angiotensin IV L-163,491 Saralasin Antagonistlar: Abitesartan Azilsartan Kandesartan Elisartan Embusartan Eprosartan EXP-3174 Fimasartan Forasartan Irbesartan Losartan Milfasartan Olmesartan Olodanrigan PD123319 Pomisartan Pratosartan Ripisartan Saprisartan Sparsentan Tasosartan Telmisartan Valsartan Zolasartan ACE inhibitörler: Alatsepril Benazepril Captopril Silazapril Delapril Enalapril Enalaprilat Fosinopril Gemopatrilat Imidapril Lisinopril Moeksipril Omapatrilat Perindopril Quinapril Kinaprilat Ramipril Rentiapril Rescinnamine Spirapril Spiraprilat Temokapril Trandolapril Zofenopril Zofenoprilat Renin inhibitörleri: Aliskiren Ciprokiren Ditekiren Enalkiren Imarikiren Pepstatin Remikiren Terlakiren Zankiren Propeptidlar: Anjiyotensinogen Angiotensin I
Kombinatsiyalar:	Amlodipin / valsartan Olmesartan / amlodipin Olmesartan / amlodipin / gidroxlorotiyazid Valsartan / gidroxlorotiyazid Valsartan / gidroxlorotiyazid / amlodipin
Shuningdek qarang Retseptorlari / signalizatsiya modulyatorlari Signal peptid / oqsil retseptorlari modulyatorlari

Klinik ma'lumotlar

ATC kodi	C09XA01 (JSSV)
Huquqiy holat
Huquqiy holat	Tergov
Identifikatorlar
IUPAC nomi (2S)-2-[(2R) -2-benzil-3- (2-metilpropan-2-sulfanil) propanamido] -N-[(2R,3S,4R) -1-sikloheksil-4-siklopropil-3,4-dihidroksibutan-2-yl] -3- (1H-imidazol-4-il) propanamid
CAS raqami	126222-34-2^Y
PubChem CID	6324659
DrugBank	DB00212^Y
ChemSpider	4884377^Y
UNII	LC7FBL96A4
KEGG	D09038^Y
ChEBI	CHEBI: 8803
ChEMBL	ChEMBL31601^Y
CompTox boshqaruv paneli (EPA)	DTXSID60155121
Kimyoviy va fizik ma'lumotlar
Formula	C₃₃H₅₀N₄O₆S
Molyar massa	630.85 g · mol⁻¹
3D model (JSmol)	Interaktiv rasm
Jilmayganlar O = S (= O) (C (C) (C) C) C [C @ H] (C (= O) N [C @ H] (C (= O) N [C @@ H) (CC1CCCCC1 ) [C @@ H] (O) [C @@ H] (O) C2CC2) Cc3cnc [nH] 3) Cc4ccccc4
InChI InChI = 1S / C33H50N4O6S / c1-33 (2,3) 44 (42,43) 20-25 (16-22-10-6-4-7-11-22) 31 (40) 37-28 (18-) 26-19-34-21-35-26) 32 (41) 36-27 (17-23-12-8-5-9-13-23) 30 (39) 29 (38) 24-14-15- 24 / h4,6-7,10-11,19,21,23-25,27-30,38-39H, 5,8-9,12-18,20H2,1-3H3, (H, 34,35) ) (H, 36,41) (H, 37,40) / t25-, 27 +, 28 +, 29 +, 30- / m1 / s1^Y Kalit: UXIGZRQVLGFTOU-VQXQMPIVSA-N^Y
(tasdiqlash)