WikiDer > Tariquidar

Tariquidar
Klinik ma'lumotlar
ATC kodi	yo'q;
Identifikatorlar
	IUPAC nomi N- [2 - [[4- [2- (6,7-Dimetoksi-3,4-dihidro-1)H-izokinolin-2-il) etil] fenil] karbamoil] -4,5-dimetoksifenil] kinolin-3-karboksamid;
CAS raqami	206873-63-4 ;
PubChem CID	148201;
ChemSpider	130650 ;
UNII	J58862DTVD;
ChEMBL	ChEMBL348475 ;
CompTox boshqaruv paneli (EPA)	DTXSID10174746 ;
Kimyoviy va fizik ma'lumotlar
Formula	C38H38N4O6
Molyar massa	646.744 g · mol−1
3D model (JSmol)	Interaktiv rasm;
	Jilmayganlar COC1 = C (C = C2CN (CCC2 = C1) CCC3 = CC = C (C = C3) NC (= O) C4 = CC (= C (C = C4NC (= O) C5 = CC6 = CC = CC = C6N = C5) OC) OC) OC;
	InChI InChI = 1S / C38H38N4O6 / c1-45-33-18-25-14-16-42 (23-28 (25) 19-34 (33) 46-2) 15-13-24-9-11-29 ( 12-10-24) 40-38 (44) 30-20-35 (47-3) 36 (48-4) 21-32 (30) 41-37 (43) 27-17-26-7-5- 6-8-31 (26) 39-22-27 / h5-12,17-22H, 13-16,23H2,1-4H3, (H, 40,44) (H, 41,43) ; Kalit: LGGHDPFKSSRQNS-UHFFFAOYSA-N ;
	(bu nima?) (tasdiqlash)

Tariquidar

Tariquidar (KARVONSAROY/USAN) a P-glikoprotein inhibitor^[1] saraton kasalligiga qarshi ko'p dori-darmonlarga qarshi yordamchi vosita sifatida tadqiqotlar olib borilmoqda.

Adabiyotlar

^ Robey RW, Shukla S, Finley EM, Oldxem RK, Barnett D, Ambudkar SV, Fojo T, Bates SE (mart 2008). "P-glikoprotein (ABCB1) - va ko'p dori-darmonlarga chidamliligi bilan bog'liq bo'lgan protein 1 (ABCC1) -ni og'iz orqali yuborilgan inhibitori, CBT-1 ((R)) orqali transportirovka qilishni taqiqlash". Biokimyoviy farmakologiya. 75 (6): 1302–12. doi:10.1016 / j.bcp.2007.12.001. PMC 2346578. PMID 18234154.

Bu antineoplastik yoki immunomodulyatsion dori maqola a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.

[pmid18234154-1] Robey RW, Shukla S, Finley EM, Oldxem RK, Barnett D, Ambudkar SV, Fojo T, Bates SE (mart 2008). "P-glikoprotein (ABCB1) - va ko'p dori-darmonlarga chidamliligi bilan bog'liq bo'lgan protein 1 (ABCC1) -ni og'iz orqali yuborilgan inhibitori, CBT-1 ((R)) orqali transportirovka qilishni taqiqlash". Biokimyoviy farmakologiya. 75 (6): 1302–12. doi:10.1016 / j.bcp.2007.12.001. PMC 2346578. PMID 18234154.

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Adabiyotlar

Klinik ma'lumotlar

ATC kodi	yo'q
Identifikatorlar
IUPAC nomi N- [2 - [[4- [2- (6,7-Dimetoksi-3,4-dihidro-1)H-izokinolin-2-il) etil] fenil] karbamoil] -4,5-dimetoksifenil] kinolin-3-karboksamid
CAS raqami	206873-63-4^Y
PubChem CID	148201
ChemSpider	130650^N
UNII	J58862DTVD
ChEMBL	ChEMBL348475^N
CompTox boshqaruv paneli (EPA)	DTXSID10174746
Kimyoviy va fizik ma'lumotlar
Formula	C₃₈H₃₈N₄O₆
Molyar massa	646.744 g · mol⁻¹
3D model (JSmol)	Interaktiv rasm
Jilmayganlar COC1 = C (C = C2CN (CCC2 = C1) CCC3 = CC = C (C = C3) NC (= O) C4 = CC (= C (C = C4NC (= O) C5 = CC6 = CC = CC = C6N = C5) OC) OC) OC
InChI InChI = 1S / C38H38N4O6 / c1-45-33-18-25-14-16-42 (23-28 (25) 19-34 (33) 46-2) 15-13-24-9-11-29 ( 12-10-24) 40-38 (44) 30-20-35 (47-3) 36 (48-4) 21-32 (30) 41-37 (43) 27-17-26-7-5- 6-8-31 (26) 39-22-27 / h5-12,17-22H, 13-16,23H2,1-4H3, (H, 40,44) (H, 41,43)^N Kalit: LGGHDPFKSSRQNS-UHFFFAOYSA-N^N
^NY (bu nima?) (tasdiqlash)