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Terlipressin
Klinik ma'lumotlar
AHFS/Drugs.com	Giyohvand moddalarning xalqaro nomlari
Marshrutlari; ma'muriyat	IV
ATC kodi	H01BA04 (JSSV) ;
Farmakokinetik ma'lumotlar
Protein bilan bog'lanish	~30%
Identifikatorlar
	IUPAC nomi 1-{[(4R,7S,10S,13S,16S,19R) -19 - {[({[(aminoatsetil) amino] asetil} amino) atsetil] amino} -7- (2-amino-2-oksoetil) -10- (3-amino-3-oksopropil) -13-benzil -16- (4-gidroksibenzil) -6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl] karbonil} -L-polil-N- (2-amino-2-oksoetil) -L-lisinamid;
CAS raqami	14636-12-5 ;
PubChem CID	72081;
DrugBank	DB02638 ;
ChemSpider	65067 ;
UNII	7Z5X49W53P;
KEGG	D06672 ;
CompTox boshqaruv paneli (EPA)	DTXSID7048952 ;
ECHA ma'lumot kartasi	100.035.149
Kimyoviy va fizik ma'lumotlar
Formula	C52H74N16O15S2
Molyar massa	1227.38 g · mol−1
3D model (JSmol)	Interaktiv rasm;
	Jilmayganlar O = C (N) CNC (= O) [C @@ H] (NC (= O) [C @ H] 4N (C (= O) [C @ H] 1NC (= O) [C @@ H ] (NC (= O) [C @@ H] (NC (= O) [C @@ H] (NC (= O) [C @@ H) (NC (= O) [C @@ H) () NC (= O) CNC (= O) CNC (= O) CN) CSSC1) Cc2ccc (O) cc2) Cc3ccccc3) CCC (= O) N) CC (= O) N) CCC4) CCCCN;
	InChI InChI = 1S / C52H74N16O15S2 / c53-17-5-4-9-31 (45 (76) 60-23-41 (57) 72) 63-51 (82) 38-10-6-18-68 (38)) 52 (83) 37-27-85-84-26-36 (61-44 (75) 25-59-43 (74) 24-58-42 (73) 22-54) 50 (81) 65-34 ( 20-29-11-13-30 (69) 14-12-29) 48 (79) 64-33 (19-28-7-2-1-3-8-28) 47 (78) 62-32 ( 15-16-39 (55) 70) 46 (77) 66-35 (21-40 (56) 71) 49 (80) 67-37 / h1-3,7-8,11-14,31-38, 69H, 4-6,9-10,15-27,53-54H2, (H2,55,70) (H2,56,71) (H2,57,72) (H, 58,73) (H, 59) , 74) (H, 60,76) (H, 61,75) (H, 62,78) (H, 63,82) (H, 64,79) (H, 65,81) (H, 66, 77) (H, 67,80) / t31-, 32-, 33-, 34-, 35-, 36-, 37-, 38- / m0 / s1 ; Kalit: BENFXAYNYRLAIU-QSVFAHTRSA-N ;
	(tasdiqlash)

Terlipressin

Terlipressin (savdo nomlari Teripress tomonidan Yangi Medicon Farmasi va Glypressin tomonidan Ferring farmatsevtika) an analog ning vazopressin vazoaktiv sifatida ishlatiladi dori boshqaruvida past qon bosimi. Qachon samarali ekanligi aniqlandi noradrenalin yordam bermaydi. Bu ham yordam beradi siyishning oldini olish.^[1]

Qo'llash ko'rsatkichlari orasida norepinefringa chidamli septik shok^[2] va gepatorenal sindrom.^[3] Bundan tashqari, u qon ketishini davolash uchun ishlatiladi qizilo'ngach tomirlari.^[4]

Mavjudligi

Terlipressin hozirda Qo'shma Shtatlarda mavjud emas,^[5] yoki Kanada,^[6] ammo u Yangi Zelandiyada mavjud,^[7] Avstraliya, Evropaning katta qismi,^[8] Hindiston, Pokiston va BAA.

Qo'llash mumkin bo'lmagan holatlar

Terlipressin homiladorlik paytida ishlatilmasligi kerak.

Shuningdek qarang

Desmopressin

Adabiyotlar

^ Kam, P. C. A .; Uilyams, S .; Yoong, F. F. Y. (2004). "Vazopressin va terlipressin: farmakologiya va uning klinik ahamiyati". Anesteziya. 59 (10): 993–1001. doi:10.1111 / j.1365-2044.2004.03877.x. ISSN 1365-2044. PMID 15488059. S2CID 26849892.
^ O'Brien A, Clapp L, Singer M (2002). "Norepinefringa chidamli septik shok uchun terlipressin". Lanset. 359 (9313): 1209–10. doi:10.1016 / S0140-6736 (02) 08225-9. PMID 11955542. S2CID 38463837.
^ Uriz J, Gines P, Kardenas A, Sort P, Ximenes V, Salmeron J, Bataller R, Mas A, Navasa M, Arroyo V, Rodes J (2000). "Terlipressin plyus albumin infuziyasi: gepatorenal sindromning samarali va xavfsiz terapiyasi". J Gepatol. 33 (1): 43–8. doi:10.1016 / S0168-8278 (00) 80158-0. PMID 10905585.
^ Ioannou G, Doust J, Rokki D (2003). Ioannou GN (tahrir). "Terlipressin qizilo'ngachning varikulyar qon ketishida". Cochrane Database Syst Rev. (1): CD002147. doi:10.1002 / 14651858.CD002147. PMC 7017851. PMID 12535432.
^ "{1} Va {2} Terepressinni 1-turdagi gepatorenal sindromda tezkor trekka belgilash haqida xabar berish - yangiliklar, ish qidirish, voqealar".
^ "Dori vositalarini qidirish". Arxivlandi asl nusxasi 2008-07-14.
^ http://www.medsafe.govt.nz/profs/datasheet/g/Glypressin01mgmlFerringinj.pdf
^ https://www.drugs.com/international/terlipressin.html

[1] Kam, P. C. A .; Uilyams, S .; Yoong, F. F. Y. (2004). "Vazopressin va terlipressin: farmakologiya va uning klinik ahamiyati". Anesteziya. 59 (10): 993–1001. doi:10.1111 / j.1365-2044.2004.03877.x. ISSN 1365-2044. PMID 15488059. S2CID 26849892.

[OBrien-2] O'Brien A, Clapp L, Singer M (2002). "Norepinefringa chidamli septik shok uchun terlipressin". Lanset. 359 (9313): 1209–10. doi:10.1016 / S0140-6736 (02) 08225-9. PMID 11955542. S2CID 38463837.

[Uriz-3] Uriz J, Gines P, Kardenas A, Sort P, Ximenes V, Salmeron J, Bataller R, Mas A, Navasa M, Arroyo V, Rodes J (2000). "Terlipressin plyus albumin infuziyasi: gepatorenal sindromning samarali va xavfsiz terapiyasi". J Gepatol. 33 (1): 43–8. doi:10.1016 / S0168-8278 (00) 80158-0. PMID 10905585.

[Ioannou-4] Ioannou G, Doust J, Rokki D (2003). Ioannou GN (tahrir). "Terlipressin qizilo'ngachning varikulyar qon ketishida". Cochrane Database Syst Rev. (1): CD002147. doi:10.1002 / 14651858.CD002147. PMC 7017851. PMID 12535432.

[5] "{1} Va {2} Terepressinni 1-turdagi gepatorenal sindromda tezkor trekka belgilash haqida xabar berish - yangiliklar, ish qidirish, voqealar".

[6] "Dori vositalarini qidirish". Arxivlandi asl nusxasi 2008-07-14.

[7] ttp://www.medsafe.govt.nz/profs/datasheet/g/Glypressin01mgmlFerringinj.pdf

[8] ttps://www.drugs.com/international/terlipressin.html

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