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Tesetaxel
Klinik ma'lumotlar
ATC kodi	yo'q;
Huquqiy holat
Huquqiy holat	Tergov;
Identifikatorlar
	IUPAC nomi (2aS, 2bR,3S,4S,6S, 8aR,10S, 11aS, 11bR, 13aR) -2a- (atsetiloksi) -6 - {[(2.)R,3S)-3-[(tert-butoksikarbonil) amino] -3- (3-floropiridin-2-yl) -2-gidroksipropanoyl] oksi} -10 - [(dimetilamino) metil] -4-gidroksi-7,11b, 14,14-tetrametil-2a, 2b, 3,4,5,6,8a, 11a, 11b, 12,13,13a-dodekahidro-2H-4,8-metano [1,3] dioksolo [3,4] siklodeka [1,2-d] [1] benzokset-3-il benzoat;
CAS raqami	333754-36-2 ;
PubChem CID	6918574;
ChemSpider	5293771 ;
UNII	UG97LO5M8Y;
Kimyoviy va fizik ma'lumotlar
Formula	C46H60FN3O13
Molyar massa	881.992 g · mol−1
3D model (JSmol)	Interaktiv rasm;
	Jilmayganlar CC1 = C2 [C @@ H] 3 [C @ H] ([C @@] 4 (CC [C @@ H] 5 [C @] ([C @ H] 4 [C @@ H] ([ C @@] (C2 (C) C) (C [C @@ H] 1OC (= O) [C @@ H] ([C @ H] (C6 = C (C = CC = N6) F) bosimining ko'tarilishi (= O) OC (C) (C) C) O) O) OC (= O) C7 = CC = CC = C7) (CO5) OC (= O) C) C) O [C @@ H] ( O3) CN (C) C;
	InChI InChI = 1S / C46H60FN3O13 / c1-24-28 (58-40 (54) 34 (52) 33 (32-27 (47) 17-14-20-48-32) 49-41 (55) 63-42) 3,4) 5) 21-46 (56) 38 (61-39 (53) 26-15-12-11-13-16-26) 36-44 (8,19-18-29-45 (36, 23-57-29) 62-25 (2) 51) 37-35 (31 (24) 43 (46,6) 7) 59-30 (60-37) 22-50 (9) 10 / h11-17, 20,28-30,33-38,52,56H, 18-19,21-23H2,1-10H3, (H, 49,55) / t28-, 29 +, 30 +, 33-, 34 +, 35 +, 36-, 37 +, 38-, 44 +, 45-, 46 + / m0 / s1 ; Kalit: MODVSQKJJIBWPZ-VLLPJHQWSA-N ;
	(bu nima?) (tasdiqlash)

Tesetaxel

Tesetaxel og'iz orqali boshqariladi takson sifatida tergov qilinmoqda kimyoviy terapiya saratonning har xil turlari uchun agent, shu jumladan ko'krak bezi saratoni,^[1] oshqozon saratoni,^[2] kolorektal saraton,^[3] va boshqa qattiq o'smalar.^[4] U taksonlar sinfining boshqa a'zolaridan farq qiladi (masalan.) paklitaksel yoki docetaxel) u tomir ichiga emas, balki og'iz orqali yuborilishi bilan.^[5]

Adabiyotlar

^ Klinik sinov raqami NCT01221870 "Tesetaxel metastatik ko'krak bezi saratonini davolashning birinchi bosqichi" uchun ClinicalTrials.gov
^ Evans T, Dobrila R, Berardi R, Sumpter KA, Wall LR, Oyama R, Anthoney DA (iyun 2006). "DJ-927 ning II bosqichli tadkikoti, 5-FU taksonsiz rejimni uddalay olmagan oshqozonning rivojlangan saraton kasalligi (GK) bo'lgan bemorlarda ikkinchi darajali davolash". Klinik onkologiya jurnali. 24 (18_suppl): 4081. doi:10.1200 / jco.2006.24.18_suppl.4081.
^ Klinik sinov raqami NCT00080834 "DJ-927 progressiv mahalliy rivojlangan yoki metastatik kolorektal adenokarsinomali bemorlarni davolashda ikkinchi darajali terapiya sifatida" uchun ClinicalTrials.gov
^ Klinik sinov raqami NCT01315431 uchun "Qattiq o'smalari bo'lgan bemorlarda Tesetaxel Plus Capecitabine-ni o'rganish" uchun ClinicalTrials.gov
^ Shionoya M, Jimbo T, Kitagava M, Soga T, Toxgo A (may 2003). "DJ-927, yangi og'zaki takson, P-glikoprotein vositachiligida in vitro va in vivo jonli ko'p dorilarga chidamliligini engib chiqadi". Saraton kasalligi. 94 (5): 459–66. doi:10.1111 / j.1349-7006.2003.tb01465.x. PMID 12824894.

Klinik ma'lumotlar

ATC kodi	yo'q
Huquqiy holat
Huquqiy holat	Tergov
Identifikatorlar
IUPAC nomi (2aS, 2bR,3S,4S,6S, 8aR,10S, 11aS, 11bR, 13aR) -2a- (atsetiloksi) -6 - {[(2.)R,3S)-3-[(tert-butoksikarbonil) amino] -3- (3-floropiridin-2-yl) -2-gidroksipropanoyl] oksi} -10 - [(dimetilamino) metil] -4-gidroksi-7,11b, 14,14-tetrametil-2a, 2b, 3,4,5,6,8a, 11a, 11b, 12,13,13a-dodekahidro-2H-4,8-metano [1,3] dioksolo [3,4] siklodeka [1,2-d] [1] benzokset-3-il benzoat
CAS raqami	333754-36-2^Y
PubChem CID	6918574
ChemSpider	5293771^N
UNII	UG97LO5M8Y
Kimyoviy va fizik ma'lumotlar
Formula	C₄₆H₆₀FN₃O₁₃
Molyar massa	881.992 g · mol⁻¹
3D model (JSmol)	Interaktiv rasm
Jilmayganlar CC1 = C2 [C @@ H] 3 [C @ H] ([C @@] 4 (CC [C @@ H] 5 [C @] ([C @ H] 4 [C @@ H] ([ C @@] (C2 (C) C) (C [C @@ H] 1OC (= O) [C @@ H] ([C @ H] (C6 = C (C = CC = N6) F) bosimining ko'tarilishi (= O) OC (C) (C) C) O) O) OC (= O) C7 = CC = CC = C7) (CO5) OC (= O) C) C) O [C @@ H] ( O3) CN (C) C
InChI InChI = 1S / C46H60FN3O13 / c1-24-28 (58-40 (54) 34 (52) 33 (32-27 (47) 17-14-20-48-32) 49-41 (55) 63-42) 3,4) 5) 21-46 (56) 38 (61-39 (53) 26-15-12-11-13-16-26) 36-44 (8,19-18-29-45 (36, 23-57-29) 62-25 (2) 51) 37-35 (31 (24) 43 (46,6) 7) 59-30 (60-37) 22-50 (9) 10 / h11-17, 20,28-30,33-38,52,56H, 18-19,21-23H2,1-10H3, (H, 49,55) / t28-, 29 +, 30 +, 33-, 34 +, 35 +, 36-, 37 +, 38-, 44 +, 45-, 46 + / m0 / s1^N Kalit: MODVSQKJJIBWPZ-VLLPJHQWSA-N^N
^NY (bu nima?) (tasdiqlash)