WikiDer > Kumermitsin A1

Kumermitsin A1
Klinik ma'lumotlar
Boshqa ismlar	Kumamitsin
ATC kodi	yo'q;
Identifikatorlar
	IUPAC nomi 3-metil-1H-pirol-2,4-diyl) bis [karbonilimino (4-gidroksi-8-metil-2-okso-2H-xromen-3,7-diyl) oksi (2R, 3R, 4S, 5R) -3-gidroksi-5-metoksi-6,6-dimetiltetrahidro-2H-piran-2,4-diyl] bis (5-metil-1H-pirol-2-karboksilat;
CAS raqami	4434-05-3 ;
PubChem CID	54675768;
ChemSpider	16736904 ;
UNII	PCH9QZ1IIH;
ChEBI	CHEBI: 3907 ;
ChEMBL	ChEMBL389471 ;
ECHA ma'lumot kartasi	100.164.703
Kimyoviy va fizik ma'lumotlar
Formula	C55H59N5O20
Molyar massa	1110.092 g · mol−1
3D model (JSmol)	Interaktiv rasm;
	Jilmayganlar CO [C @@ H] 1 [C @ H] (OC (= O) c2ccc (C) [nH] 2) [C @@ H] (O) [C @ H] (Oc2ccc3c (O) c (NC) (= O) c4c [nH] c (C (= O) Nc5c (= O) oc6c (C) c (ccc6c5O) O [C @@ H] 5OC (C) (C) [C @ H] (OC) [C @ H] (OC (= O) c6ccc (C) [nH] 6) [C @ H] 5O) c4C) c (= O) oc3c2C) OC1 (C) C;
	InChI InChI = 1S / C55H59N5O20 / c1-21-12-16-29 (57-21) 48 (67) 77-42-38 (63) 52 (79-54 (6,7) 44 (42) 71-10) 73-31-18-14-26-36 (61) 34 (50 (69) 75-40 (26) 24 (31) 4) 59-46 (65) 28-20-56-33 (23 (28)) 3) 47 (66) 60-35-37 (62) 27-15-19-32 (25 (5) 41 (27) 76-51 (35) 70) 74-53-39 (64) 43 (45) 72-11) 55 (8,9) 80-53) 78-49 (68) 30-17-13-22 (2) 58-30 / h12-20,38-39,42-45,52-53, 56-58,61-64H, 1-11H3, (H, 59,65) (H, 60,66) / t38-, 39-, 42 +, 43 +, 44-, 45-, 52-, 53- / m1 / s1 ; Kalit: WTIJXIZOODAMJT-DHFGXMAYSA-N ;
	(bu nima?) (tasdiqlash)

Coumermycin A1

Kumermitsin A1 bu aminokumarin.^[1]^[2] Uning asosiy maqsadi ATPase sayt DNK-giraza GyrB kichik birligi.^[3]

Shuningdek qarang

^ Heide L (2009). "Yangi aminokumarinlarni yaratish uchun antibiotiklar biosintezining genetik muhandisligi". Biotexnologiya yutuqlari. 27 (6): 1006–1014. doi:10.1016 / j.biotechadv.2009.05.017. PMID 19463934.
^ Heide L, Gust B, Anderle C, Li SM (2008). "Yangi aminokumarin antibiotiklarini yaratish uchun kombinatorial biosintez, metabolik muhandislik va mutasintez". Tibbiy kimyoning dolzarb mavzulari. 8 (8): 667–79. doi:10.2174/156802608784221505. PMID 18473891.
^ Vanden Broek A, McEwen AG, Chebaro Y, Potier N, Lamour V (aprel 2019). "DNK-girazning kumermitsin A1 bilan o'zaro ta'sirlanishining tarkibiy asoslari". Tibbiy kimyo jurnali. 62 (8): 4225–4231. doi:10.1021 / acs.jmedchem.8b01928. PMID 30920824.

Ushbu tizimli antibiotikbilan bog'liq maqola a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.