WikiDer > Dagrokorat
Dagrocorat
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| Klinik ma'lumotlar | |
|---|---|
| Boshqa ismlar | PF-00251802; PF-251802 |
| Giyohvand moddalar sinfi | Tanlangan glyukokortikoid retseptorlari modulyatori |
| Identifikatorlar | |
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| CAS raqami | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| KEGG | |
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| CompTox boshqaruv paneli (EPA) | |
| Kimyoviy va fizik ma'lumotlar | |
| Formula | C29H29F3N2O2 |
| Molyar massa | 494.558 g · mol−1 |
| 3D model (JSmol) | |
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Dagrokorat (rivojlanish kodlari nomlari PF-00251802, PF-251802) a steroid bo'lmagan lekin steroido'xshash selektiv glyukokortikoid retseptorlari modulyatori (SGRM) davolash uchun ishlab chiqilgan edi romatoid artrit lekin hech qachon sotilmadi.[1][2][3][4] Bu a qisman agonist va "ajraladigan" agonist ning glyukokortikoid retseptorlari.[5][6] Dori yetdi I bosqich klinik sinovlar uning rivojlanishi to'xtatilgunga qadar.[1][3][4] C2a dihidrogen fosfat Ester dagrokorat, fosdagrocorat, shuningdek, tergov ostida bo'lgan, ammo uning rivojlanishi ham to'xtatilgan.[7]
Shuningdek qarang
Adabiyotlar
- ^ a b http://adisinsight.springer.com/drugs/800029003
- ^ https://www.who.int/medicines/publications/druginformation/innlists/PL111.pdf
- ^ a b Yoshioka H, Yamada A, Nishiyama Y, Kagechika H, Xashimoto Y, Fujii S (2017). "N-benzil-N- (4-fenoksifenil) benzensulfonamid iskala asosida nosteroid glyukokortikoid retseptorlari modulyatorlarini yaratish". Bioorg. Med. Kimyoviy. 25 (13): 3461–3470. doi:10.1016 / j.bmc.2017.04.032. PMID 28506584.
- ^ a b Strehl C, van der Goes MC, Bijlsma JW, Jacobs JW, Buttgereit F (2017). "Romatoid artritni davolash uchun glyukokortikoidli davolash". Ekspert Opin Dori vositalari. 26 (2): 187–195. doi:10.1080/13543784.2017.1276562. PMID 28043173.
- ^ Miyoshi S, Hey-Hadavi J, Nagaoka M, Tammara B (2016). "Sog'lom kattalar Kavkaz va Yaponiya sub'ektlarida glyukokortikoid retseptorlari dissotsiatsiyalangan agonisti bo'lgan fosdagrokoratning farmakokinetikasi va oziq-ovqat ta'siri (PF-04171327)". Int J Clin Pharmacol Ther. 54 (12): 966–976. doi:10.5414 / CP202659. PMID 27781421.
- ^ Stock T, Fleishaker D, Vang X, Mukherjee A, Mebus C (2017). "Romatoid artritli bemorlarda glyukokortikoid retseptorlari qisman agonisti bo'lgan fosdagrokorat (PF-04171327) bilan kasallikning faolligi yaxshilandi: randomizatsiyalangan 2-bosqich". Int J Rheum Dis. doi:10.1111 / 1756-185X.13053. PMC 6084298. PMID 28328159.
- ^ http://adisinsight.springer.com/drugs/800029004
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