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Vestipitant
Klinik ma'lumotlar
ATC kodi	Yo'q;
Identifikatorlar
	IUPAC nomi (2S)-N-{(1R) -1- [3,5-bis (triflorometil); fenil] etil} -2- (4-ftor-2-metilfenil) -N-metilpiperazin-1-karboksamid;
CAS raqami	334476-64-1 ;
PubChem CID	9832383;
IUPHAR / BPS	5757;
ChemSpider	8008111 ;
UNII	S052TOI9BI;
KEGG	D06293 ;
ChEMBL	ChEMBL522987 ;
CompTox boshqaruv paneli (EPA)	DTXSID50187092 ;
Kimyoviy va fizik ma'lumotlar
Formula	C23H21F10N3O
Molyar massa	545.425 g · mol−1
3D model (JSmol)	Interaktiv rasm;
	Jilmayganlar FC (F) (F) c1cc (F) ccc1C2CNCCN2C (= O) N (C) C (C) c3cc (C (F) (F) F) cc (c3) C (F) (F) F;
	InChI InChI = 1S / C23H24F7N3O / c1-13-8-18 (24) 4-5-19 (13) 20-12-31-6-7-33 (20) 21 (34) 32 (3) 14 (2) 15-9-16 (22 (25,26) 27) 11-17 (10-15) 23 (28,29) 30 / h4-5,8-11,14,20,31H, 6-7,12H2, 1-3H3 / t14-, 20- / m1 / s1 ; Kalit: SBBYBXSFWOLDDG-JLTOFOAXSA-N ;
	(bu nima?) (tasdiqlash)

Vestipitant

Vestipitant (KARVONSAROY)^[1]^:98 tomonidan ishlab chiqarilgan dori GlaxoSmithKline bu tanlov vazifasini bajaradi antagonist uchun NK₁ retseptorlari. U potentsial sifatida ishlab chiqilmoqda qusishga qarshi va anksiyolitik dori,^[2]^[3] va davolanish sifatida tinnitus^[4] va uyqusizlik.^[5]

Shuningdek qarang

^ "Farmatsevtika moddalari uchun xalqaro nomuvofiq nomlar (INN). Tavsiya etilgan xalqaro nomuvofiq nomlar: 53-ro'yxat" (PDF). Jahon Sog'liqni saqlash tashkiloti. Olingan 17 noyabr 2016.
^ Reddy GK, Gralla RJ, Hesketh PJ (aprel 2006). "Yangi neyrokinin-1 antagonistlari kimyoviy davolash natijasida qusishni davolash uchun antiemetika". Saraton kasalligini davolash. 3 (3): 140–2. doi:10.3816 / SCT.2006.n.011. PMID 18632487.
^ Brokko M, Dekeyne A, Mannoury la Cour C, Touzard M, Girardon S, Veiga S va boshq. (Oktyabr 2008). "Romanning uyali va xulq-atvori, selektiv neyrokinin1 retseptorlari antagonisti, vestipitant: boshqa agentlarga taqqoslash". Evropa neyropsikofarmakologiyasi. 18 (10): 729–50. doi:10.1016 / j.euroneuro.2008.06.002. PMID 18657401.
^ Klinik sinov raqami NCT00394056 "Tinnitus va eshitish qobiliyati yo'qolgan mavzulardagi vestipitant yoki vestipitant / paroksetin kombinatsiyasi" uchun ClinicalTrials.gov
^ Ratti E, Carpenter DJ, Zamuner S, Fernandes S, Squassante L, Danker-Hopfe H va boshq. (2013 yil dekabr). "Birlamchi uyqusizlikda vestipitant, neyrokinin-1 retseptorlari antagonisti". Uyqu. 36 (12): 1823–30. doi:10.5665 / uyqu.3208. PMC 3825431. PMID 24293756.

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v t e Qusishga qarshi vositalar (A04)
5-HT₃ serotonin ioni kanal antagonistlari	Alosetron Azasetron Bemesetron Cilansetron Klozapin Dazoprid Dolasetron Granisetron Lerisetron Metoklopramid Mianserin Mirtazapin Olanzapin Ondansetron Palonosetron (+ netupitant) Ketiapin Ramosetron Rikasetron Tropisetron Zatosetron
5-HT serotonin G-oqsil retseptorlari antagonistlari	Klozapin Siproheptadin Gidroksizin Olanzapin Risperidon Ziprasidon
CB₁ agonistlar (kanabinoidlar)	Dronabinol Nabilone Tetrahidrokannabinol (nasha)
D.₂/ D.₃ antagonistlar	Alizaprid Bromoprid Xlorpromazin Kleboprid Domperidon Haloperidol Gidroksizin Itoprid Metoklopramid Metopimazin Proxlorperazin Tietilperazin Trimetobenzamid
H₁ antagonistlar (antigistaminlar)	Siklizin Dimenhidrinat Difengidramin Gidroksizin Meklizin Prometazin
mACh antagonistlar (antikolinerjiklar)	Atropin Difengidramin Gidroksizin (juda yumshoq) Giyosiyamin Skopolamin
NK₁ antagonistlar	Yaxshi Kasopitant Ezlopitant Fosaprepitant Maropitant Netupitant Rolapitant Vestipitant
Boshqalar	Seriy oksalat Deksametazon Lorazepam Midazolam Propofol

v t e Neyrokinin retseptorlari modulyatorlar
NK₁	Agonistlar: P moddasi Antagonistlar: Yaxshi Befetupitant Burapitant Kasopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743,310 L-758,298 Lanepitant LY-306740 Maropitant Netupitant NKP-608 Nolpitantium susayadi Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant
NK₂	Agonistlar: Neyrokinin A Antagonistlar: GR-159897 Ibodutant Nepadutant Saredutant
NK₃	Agonistlar: Neyrokinin B Senktayd Antagonistlar: Fezolinetant (ESN-364) Osanetant (SR-142,801) Pavinetant (MLE-4901, AZD-2624, AZD-4901) SB-218,795 SB-222,200 Taletant (SB-223,412)
Shuningdek qarang: Retseptor / signalizatsiya modulyatorlari • Signal peptid / oqsil retseptorlari modulyatorlari

Klinik ma'lumotlar

ATC kodi	Yo'q
Identifikatorlar
IUPAC nomi (2S)-N-{(1R) -1- [3,5-bis (triflorometil) fenil] etil} -2- (4-ftor-2-metilfenil) -N-metilpiperazin-1-karboksamid
CAS raqami	334476-64-1^Y
PubChem CID	9832383
IUPHAR / BPS	5757
ChemSpider	8008111^N
UNII	S052TOI9BI
KEGG	D06293^N
ChEMBL	ChEMBL522987^N
CompTox boshqaruv paneli (EPA)	DTXSID50187092
Kimyoviy va fizik ma'lumotlar
Formula	C₂₃H₂₁F₁₀N₃O
Molyar massa	545.425 g · mol⁻¹
3D model (JSmol)	Interaktiv rasm
Jilmayganlar FC (F) (F) c1cc (F) ccc1C2CNCCN2C (= O) N (C) C (C) c3cc (C (F) (F) F) cc (c3) C (F) (F) F
InChI InChI = 1S / C23H24F7N3O / c1-13-8-18 (24) 4-5-19 (13) 20-12-31-6-7-33 (20) 21 (34) 32 (3) 14 (2) 15-9-16 (22 (25,26) 27) 11-17 (10-15) 23 (28,29) 30 / h4-5,8-11,14,20,31H, 6-7,12H2, 1-3H3 / t14-, 20- / m1 / s1^N Kalit: SBBYBXSFWOLDDG-JLTOFOAXSA-N^N
^NY (bu nima?) (tasdiqlash)