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Etaracizumab - Wikipedia

Etaracizumab
Monoklonal antikor
Turi	Butun antikor
Manba	Insoniylashtirilgan (dan.) sichqoncha)
Maqsad	alfa-v beta-3 integral
Klinik ma'lumotlar
Savdo nomlari	Abegrin
ATC kodi	yo'q
Identifikatorlar
CAS raqami	892553-42-3^N
ChemSpider	yo'q
UNII	41W9MFI160
KEGG	D09342^Y
Kimyoviy va fizik ma'lumotlar
Formula	C₆₃₉₂H₉₉₀₈N₁₇₃₂O₁₉₉₆S₄₂
Molyar massa	144302.22 g · mol⁻¹
^NY (bu nima?) (tasdiqlash)

Etaracizumab, shuningdek, nomi bilan tanilgan etaratuzumab,^{[iqtibos kerak]} MEDI-522, savdo nomi Abegrin, a insonparvarlashtirilgan monoklonal antikor davolash uchun tergov qilinmoqda metastatik melanoma, prostata saratoni,^[1] tuxumdon saratoni^[2] va boshqa har xil saraton turlari.^[3] U tomonidan ishlab chiqarilgan MedImmune.^[1]

Bu yaxshilangan iteratsiya Vitaksin, MEDI-523 nomi bilan ham tanilgan. Ikkalasi ham sichqonchani LM609 antikoridan olingan.^[4]

Adabiyotlar

^ ^a ^b "Etaracizumab" (PDF). Usan Kengashi tomonidan qabul qilingan nomuvofiq nom to'g'risidagi bayonot.
^ Landen CN, Kim TJ, Lin YG, Merritt WM, Kamat AA, Xan LY va boshq. (2008 yil noyabr). "Yumurtalik saratonida alfavbeta3 integralini antitel vositachiligiga yo'naltirilgan o'sma-selektiv javob". Neoplaziya. 10 (11): 1259–67. doi:10.1593 / neo.08740. PMC 2570602. PMID 18953435.
^ Delbaldo C, Raymond E, Vera K, Hammershaimb L, Kaucic K, Lozahic S va boshq. (2008 yil fevral). "I bosqich va farmakokinetik o'rganish, etaratsizumab (Abegrin), alfaavbeta3 integralin retseptorlariga qarshi insonparvarlashtirilgan monoklonal antikor, rivojlangan qattiq o'smalari bo'lgan bemorlarda". Tergovning yangi dori vositalari. 26 (1): 35–43. doi:10.1007 / s10637-007-9077-0. PMID 17876527. S2CID 37221398.
^ McNeel DG, Eickhoff J, Lee FT, King DM, Alberti D, Thomas JP va boshq. (2005 yil noyabr). "Ilk bosqichda alfavbeta3 integraliga (MEDI-522) xos bo'lgan monoklonal antikorni yuqori darajadagi badjahl kasalligi bo'lgan bemorlarda sinab ko'rish, shu jumladan o'sma perfuziyasiga ta'sirini baholash". Klinik saraton tadqiqotlari. 11 (21): 7851–60. doi:10.1158 / 1078-0432.CCR-05-0262. PMID 16278408.

Monoklonallar suyak, tayanch-harakat, qon aylanish va nevrologik tizimlar uchun

Suyak ("-os-", "-s (o) -")

Inson ("-osu-")	Burosumab Denosumab
Insonparvarlashtirilgan ("-sozu-")	Blosozumab Romosozumab

Mushak-skelet ("-mul-")

Inson ("-mulu-")	Stamulumab^†

Qon aylanishi ("-c (i [r]) -")

Inson ("-ciru-")	Alirokumab Ascrinvacumab Enoticumab Evinakumab^† Evolokumab Ikrucumab Inclacumab Nesvakumab Ortikumab Ramucirumab Rinukumab
Sichqoncha ("-ciro-")	Biciromab^‡ Imciromab^‡
Ximerik ("-cixi-")	Abxiksimab Voloksiximab
Insoniylashtirilgan ("-cizu-")	Alatsizumab pegol Bevatsizumab/Ranibizumab Bokotsizumab Brolucizumab Caplacizumab Demcizumab Etaracizumab Faricimab^† Idarucizumab Ralpansizumab Tadocizumab Vanucizumab

Nevrologik ("-ne (u) (r) -")

Inson ("-neru-")	Aducanumab^† Erenumab Fasinumab^† Fulranumab Gantenerumab^† Opicinumab
Insoniylashtirilgan ("-nezu -" / "- neuzu-")	Bapineuzumab^† Krenezumab^† Eptinezumab Fremanezumab Galcanezumab Ozanezumab Ponezumab Refanezumab Solanezumab Tanezumab^†

Anjiyogenez inhibitori ("-anibi-")

Insoniylashtirilgan ("-anibizu-")	Ranibizumab

O'sish omili ("-gr (o) -")

Inson ("-gru-")	Bimagrumab Trevogrumab
Insonparvarlik ("-grozu-")	Domagrozumab Landogrozumab

^#JSST-EM
^‡Olingan bozordan
Klinik sinovlar:
- ^†III bosqich
- ^§Hech qachon III bosqichga

Monoklonal antikorlar o'smalar uchun

Shish

Inson	Adekatumumab^§ Ascrinvacumab^§ Atezolizumab Cixutumumab^§ Konatumumab^§ Daratumumab Drozitumab^§ Duligotumab^§ Dusigitumab^§ Enfortumab vedotin Enoticumab^§ Figitumumab^§ Ganitumab^† Glembatumumab vedotin^† Intetumumab^§ Ipilimumab Iratumumab^§ Istiratumab Ikrucumab^§ Lexatumumab^§ Lucatumumab^§ Mapatumumab^§ Narnatumab^§ Necitumumab Nesvakumab^§ Nivolumab^# Ofatumumab Olaratumab^† Panitumumab Patritumab^§ Pembrolizumab^# Pritumumab^§ Radretumab^§ Ramucirumab Rilotumumab^† Robatumumab^§ Seribantumab^§ Tarextumab^§ Teprotumumab^† Tovetumab^§ Vantiktumab^§ Votumumab^§ Zalutumumab^† "-melu-" (melanoma) Flanvotumab^§
Sichqoncha	Altumomab pentetat Anatumomab mafenatoks Arcitumomab Bektumomab Blinatumomab Detumomab Ibritumomab tiuxetan Lilotomab Minretumomab Mitumomab Moxetumomab pasudotoks Naptumomab estafenatoks Nofetumomab merpentan Pemtumomab^† Pintumomab Racotumomab Satumomab pendetid Solitomab Taplitumomab paptoxi Tenatumomab Tositumomab 3F8 "-govo-" (tuxumdon o'smasi) Abagovomab Igovomab Oregovomab "-pro-" (prostata bezining shishi) Kapromab pendetid "-colo-" (yo'g'on ichak shishi) Edrecolomab Nacolomab tafenatoks
Ximerik	Amatuximab^§ Bavituximab^§ Brentuximab vedotin Karotuximab^† Cetuximab Derlotuximab biotin^§ Dinutuximab Ensituximab^§ Futuximab^§ Girentuximab^† Indatuximab ravtansine^§ Isatuximab Loncastuximab tesirine Margetuximab^† Rituximab^# Siltuximab Ublituximab^† IMAB362 "-mexi-" (melanoma): Ekromeximab^§
Insoniylashtirilgan	Abituzumab^§ Alemtuzumab Belantamab mafodotin Bevatsizumab Bivatuzumab mertansin^§ Brontictuzumab^§ Kantuzumab mertansin^§ Kantuzumab ravtansin^§ Cirmtuzumab Citatuzumab bogatoks^§ Clivatuzumab tetraxetan Cofetuzumab pelidotin Dacetuzumab^§ Demcizumab^§ Dalotuzumab^§ Denintuzumab mafodotin^§ Elotuzumab Emaktuzumab^§ Emibetuzumab^§ Enoblituzumab^§ Etaracizumab^§ Farletuzumab^§ Fiklatuzumab^§ Flotetuzumab^§ Gemtuzumab ozogamitsin Imgatuzumab^§ Inotuzumab ozogamitsin Labetuzumab^§ Lifastuzumab vedotin^§ Lintuzumab^§ Lorvotuzumab mertansin^§ Lumretuzumab^§ Matuzumab^§ Milatuzumab^§ Naxitamab Nimotuzumab^† Obinutuzumab Ocaratuzumab^§ Otlertuzumab^§ Onartuzumab^§ Oportuzumab monatoks^† Parsatuzumab^§ Pertuzumab Pinatuzumab vedotin^§ Polatuzumab vedotin Rosmantuzumab Rovalpituzumab tesirine^† Sacituzumab govitecan Sibrotuzumab^§ Simtuzumab^§ Tacatuzumab tetraxetan^§ Tigatuzumab^§ Trastuzumab^# Tucotuzumab celmoleukin^§ Vandortuzumab vedotin^§ Vanucizumab^§ Veltuzumab^§ Vorsetuzumab mafodotin^§ CBR96-doksorubitsin immunokonjugati PankoMab "-gozu-" (tuxumdon o'smasi) Sofituzumab vedotin^§
Sichqoncha / sichqoncha gibrid	Katumaxomab Ertumaxomab^§
Ximerik + insonparvarlashtirilgan	Depatuxizumab mafodotin^† Duvortuxizumab Ontuxizumab^§

^#JSST-EM
^‡Olingan bozordan
Klinik sinovlar:
- ^†III bosqich
- ^§Hech qachon III bosqichga

Bu monoklonal antikor- tegishli maqola a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.

Bu antineoplastik yoki immunomodulyatsion dori maqola a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.

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