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Vanucizumab

Vanucizumab
Monoklonal antikor
Turi	Butun antikor
Manba	Insoniylashtirilgan
Maqsad	angiopoietin 2
Klinik ma'lumotlar
Boshqa ismlar	RG7221
ATC kodi	yo'q
Identifikatorlar
CAS raqami	1448221-05-3
ChemSpider	yo'q
UNII	B800Z06O8K
KEGG	D11244
Kimyoviy va fizik ma'lumotlar
Formula	C₆₅₂₉H₁₀₀₃₃N₁₇₃₃O₂₀₃₈S₄₆
Molyar massa	146887.94 g · mol⁻¹

Vanucizumab (KARVONSAROY; ishlab chiqish kodi RG7221) eksperimental hisoblanadi insonparvarlashgan monoklonal antikor saraton kasalligini davolash uchun mo'ljallangan.^[1]^[2]

Vanucizumab - bu ikki xil og'ir zanjir va ikki xil yorug'lik zanjiridan tashkil topgan ikki o'ziga xos monoklonal antikor. Antikorning bir qo'li bog'lanadi Angiopoietin-2 (Ang2) va boshqasiga asoslanadi bevacizumab (Avastin), bog'laydigan qon tomir endotelial o'sish faktori A (VEGF-A). Antikor, VEGF-A va Ang2 ni bir vaqtning o'zida inhibe qilish uchun mo'ljallangan bo'lib, faqatgina VEGF-A inhibisyonuna nisbatan yuqori klinik foyda keltiradi.

Ushbu preparat tomonidan ishlab chiqilgan Genentech/Roche.

Adabiyotlar

^ USAN Kengashi tomonidan qabul qilingan nomuvofiq nom to'g'risida bayonot - Vanucizumab, Amerika tibbiyot assotsiatsiyasi.
^ Jahon Sog'liqni saqlash tashkiloti (2014). "Farmatsevtik moddalar uchun xalqaro nomuvofiq nomlar (INN). Taklif qilingan INN: 111-ro'yxat" (PDF). JSST giyohvand moddalar to'g'risida ma'lumot. 28 (2).

Monoklonal antikorlar o'smalar uchun

Shish

Inson	Adekatumumab^§ Ascrinvacumab^§ Atezolizumab Cixutumumab^§ Konatumumab^§ Daratumumab Drozitumab^§ Duligotumab^§ Dusigitumab^§ Enfortumab vedotin Enoticumab^§ Figitumumab^§ Ganitumab^† Glembatumumab vedotin^† Intetumumab^§ Ipilimumab Iratumumab^§ Istiratumab Ikrucumab^§ Lexatumumab^§ Lucatumumab^§ Mapatumumab^§ Narnatumab^§ Necitumumab Nesvakumab^§ Nivolumab^# Ofatumumab Olaratumab^† Panitumumab Patritumab^§ Pembrolizumab^# Pritumumab^§ Radretumab^§ Ramucirumab Rilotumumab^† Robatumumab^§ Seribantumab^§ Tarextumab^§ Teprotumumab^† Tovetumab^§ Vantiktumab^§ Votumumab^§ Zalutumumab^† "-melu-" (melanoma) Flanvotumab^§
Sichqoncha	Altumomab pentetat Anatumomab mafenatoks Arcitumomab Bektumomab Blinatumomab Detumomab Ibritumomab tiuxetan Lilotomab Minretumomab Mitumomab Moxetumomab pasudotoks Naptumomab estafenatoks Nofetumomab merpentan Pemtumomab^† Pintumomab Racotumomab Satumomab pendetid Solitomab Taplitumomab paptoxi Tenatumomab Tositumomab 3F8 "-govo-" (tuxumdon o'smasi) Abagovomab Igovomab Oregovomab "-pro-" (prostata bezining shishi) Kapromab pendetid "-colo-" (yo'g'on ichak shishi) Edrecolomab Nacolomab tafenatoks
Ximerik	Amatuximab^§ Bavituximab^§ Brentuximab vedotin Karotuximab^† Cetuximab Derlotuximab biotin^§ Dinutuximab Ensituximab^§ Futuximab^§ Girentuximab^† Indatuximab ravtansine^§ Isatuximab Loncastuximab tesirine Margetuximab^† Rituximab^# Siltuximab Ublituximab^† IMAB362 "-mexi-" (melanoma): Ekromeximab^§
Insoniylashtirilgan	Abituzumab^§ Alemtuzumab Belantamab mafodotin Bevatsizumab Bivatuzumab mertansin^§ Brontictuzumab^§ Kantuzumab mertansin^§ Kantuzumab ravtansin^§ Cirmtuzumab Citatuzumab bogatoks^§ Clivatuzumab tetraxetan Cofetuzumab pelidotin Dacetuzumab^§ Demcizumab^§ Dalotuzumab^§ Denintuzumab mafodotin^§ Elotuzumab Emaktuzumab^§ Emibetuzumab^§ Enoblituzumab^§ Etaracizumab^§ Farletuzumab^§ Fiklatuzumab^§ Flotetuzumab^§ Gemtuzumab ozogamitsin Imgatuzumab^§ Inotuzumab ozogamitsin Labetuzumab^§ Lifastuzumab vedotin^§ Lintuzumab^§ Lorvotuzumab mertansin^§ Lumretuzumab^§ Matuzumab^§ Milatuzumab^§ Naxitamab Nimotuzumab^† Obinutuzumab Ocaratuzumab^§ Otlertuzumab^§ Onartuzumab^§ Oportuzumab monatoks^† Parsatuzumab^§ Pertuzumab Pinatuzumab vedotin^§ Polatuzumab vedotin Rosmantuzumab Rovalpituzumab tesirine^† Sacituzumab govitecan Sibrotuzumab^§ Simtuzumab^§ Tacatuzumab tetraxetan^§ Tigatuzumab^§ Trastuzumab^# Tucotuzumab celmoleukin^§ Vandortuzumab vedotin^§ Vanucizumab^§ Veltuzumab^§ Vorsetuzumab mafodotin^§ CBR96-doksorubitsin immunokonjugati PankoMab "-gozu-" (tuxumdon o'smasi) Sofituzumab vedotin^§
Sichqoncha / sichqoncha gibrid	Katumaxomab Ertumaxomab^§
Ximerik + insonparvarlashtirilgan	Depatuxizumab mafodotin^† Duvortuxizumab Ontuxizumab^§

^#JSST-EM
^‡Olingan bozordan
Klinik sinovlar:
- ^†III bosqich
- ^§Hech qachon III bosqichga

Monoklonallar suyak, tayanch-harakat, qon aylanish va nevrologik tizimlar uchun

Suyak ("-os-", "-s (o) -")

Inson ("-osu-")	Burosumab Denosumab
Insonparvarlashtirilgan ("-sozu-")	Blosozumab Romosozumab

Mushak-skelet ("-mul-")

Inson ("-mulu-")	Stamulumab^†

Qon aylanishi ("-c (i [r]) -")

Inson ("-ciru-")	Alirokumab Ascrinvacumab Enoticumab Evinakumab^† Evolokumab Ikrucumab Inclacumab Nesvakumab Ortikumab Ramucirumab Rinukumab
Sichqoncha ("-ciro-")	Biciromab^‡ Imciromab^‡
Ximerik ("-cixi-")	Abxiksimab Voloksiximab
Insoniylashtirilgan ("-cizu-")	Alatsizumab pegol Bevatsizumab/Ranibizumab Bokotsizumab Brolucizumab Caplacizumab Demcizumab Etaracizumab Faricimab^† Idarucizumab Ralpansizumab Tadocizumab Vanucizumab

Nevrologik ("-ne (u) (r) -")

Inson ("-neru-")	Aducanumab^† Erenumab Fasinumab^† Fulranumab Gantenerumab^† Opicinumab
Insoniylashtirilgan ("-nezu -" / "- neuzu-")	Bapineuzumab^† Krenezumab^† Eptinezumab Fremanezumab Galcanezumab Ozanezumab Ponezumab Refanezumab Solanezumab Tanezumab^†

Anjiyogenez inhibitori ("-anibi-")

Insoniylashtirilgan ("-anibizu-")	Ranibizumab

O'sish omili ("-gr (o) -")

Inson ("-gru-")	Bimagrumab Trevogrumab
Insonparvarlik ("-grozu-")	Domagrozumab Landogrozumab

^#JSST-EM
^‡Olingan bozordan
Klinik sinovlar:
- ^†III bosqich
- ^§Hech qachon III bosqichga

Bu monoklonal antikor- tegishli maqola a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.

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