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Dalotuzumab

Dalotuzumab
Monoklonal antikor
Turi	Butun antikor
Manba	Insoniylashtirilgan (dan.) sichqoncha)
Maqsad	IGF-1 retseptorlari
Klinik ma'lumotlar
ATC kodi	yo'q
Identifikatorlar
CAS raqami	1005389-60-5^N
ChemSpider	yo'q
UNII	6YI1L648RH
KEGG	D09746
ECHA ma'lumot kartasi	100.205.569
Kimyoviy va fizik ma'lumotlar
Formula	C₆₅₂₈H₁₀₀₈₆N₁₇₃₀O₂₀₁₈S₄₀
Molyar massa	146374.99 g · mol⁻¹
^NY (bu nima?) (tasdiqlash)

Dalotuzumab saraton kasalligini davolash uchun mo'ljallangan, insonparvarlashtirilgan monoklonal antikor.^[1]

Dalotuzumab tomonidan ishlab chiqilgan Merck & Co., Inc.

Adabiyotlar

^ "USAN Kengashi tomonidan qabul qilingan nomuvofiq nom to'g'risida bayonot: Dalotuzumab" (PDF). Amerika tibbiyot assotsiatsiyasi.

Monoklonal antikorlar o'smalar uchun

Inson	Adekatumumab^§ Ascrinvacumab^§ Atezolizumab Cixutumumab^§ Konatumumab^§ Daratumumab Drozitumab^§ Duligotumab^§ Dusigitumab^§ Enfortumab vedotin Enoticumab^§ Figitumumab^§ Ganitumab^† Glembatumumab vedotin^† Intetumumab^§ Ipilimumab Iratumumab^§ Istiratumab Ikrucumab^§ Lexatumumab^§ Lucatumumab^§ Mapatumumab^§ Narnatumab^§ Necitumumab Nesvakumab^§ Nivolumab^# Ofatumumab Olaratumab^† Panitumumab Patritumab^§ Pembrolizumab^# Pritumumab^§ Radretumab^§ Ramucirumab Rilotumumab^† Robatumumab^§ Seribantumab^§ Tarextumab^§ Teprotumumab^† Tovetumab^§ Vantiktumab^§ Votumumab^§ Zalutumumab^† "-melu-" (melanoma) Flanvotumab^§
Sichqoncha	Altumomab pentetat Anatumomab mafenatoks Arcitumomab Bektumomab Blinatumomab Detumomab Ibritumomab tiuxetan Lilotomab Minretumomab Mitumomab Moxetumomab pasudotoks Naptumomab estafenatoks Nofetumomab merpentan Pemtumomab^† Pintumomab Racotumomab Satumomab pendetid Solitomab Taplitumomab paptoxi Tenatumomab Tositumomab 3F8 "-govo-" (tuxumdon o'smasi) Abagovomab Igovomab Oregovomab "-pro-" (prostata bezining shishi) Kapromab pendetid "-colo-" (yo'g'on ichak shishi) Edrecolomab Nacolomab tafenatoks
Ximerik	Amatuximab^§ Bavituximab^§ Brentuximab vedotin Karotuximab^† Cetuximab Derlotuximab biotin^§ Dinutuximab Ensituximab^§ Futuximab^§ Girentuximab^† Indatuximab ravtansine^§ Isatuximab Loncastuximab tesirine Margetuximab^† Rituximab^# Siltuximab Ublituximab^† IMAB362 "-mexi-" (melanoma): Ekromeximab^§
Insoniylashtirilgan	Abituzumab^§ Alemtuzumab Belantamab mafodotin Bevatsizumab Bivatuzumab mertansin^§ Brontictuzumab^§ Kantuzumab mertansin^§ Kantuzumab ravtansin^§ Cirmtuzumab Citatuzumab bogatoks^§ Clivatuzumab tetraxetan Cofetuzumab pelidotin Dacetuzumab^§ Demcizumab^§ Dalotuzumab^§ Denintuzumab mafodotin^§ Elotuzumab Emaktuzumab^§ Emibetuzumab^§ Enoblituzumab^§ Etaracizumab^§ Farletuzumab^§ Fiklatuzumab^§ Flotetuzumab^§ Gemtuzumab ozogamitsin Imgatuzumab^§ Inotuzumab ozogamitsin Labetuzumab^§ Lifastuzumab vedotin^§ Lintuzumab^§ Lorvotuzumab mertansin^§ Lumretuzumab^§ Matuzumab^§ Milatuzumab^§ Naxitamab Nimotuzumab^† Obinutuzumab Ocaratuzumab^§ Otlertuzumab^§ Onartuzumab^§ Oportuzumab monatoks^† Parsatuzumab^§ Pertuzumab Pinatuzumab vedotin^§ Polatuzumab vedotin Rosmantuzumab Rovalpituzumab tesirine^† Sacituzumab govitecan Sibrotuzumab^§ Simtuzumab^§ Tacatuzumab tetraxetan^§ Tigatuzumab^§ Trastuzumab^# Tucotuzumab celmoleukin^§ Vandortuzumab vedotin^§ Vanucizumab^§ Veltuzumab^§ Vorsetuzumab mafodotin^§ CBR96-doksorubitsin immunokonjugati PankoMab "-gozu-" (tuxumdon o'smasi) Sofituzumab vedotin^§
Sichqoncha / sichqoncha gibrid	Katumaxomab Ertumaxomab^§
Ximerik + insonparvarlashtirilgan	Depatuxizumab mafodotin^† Duvortuxizumab Ontuxizumab^§

^#JSST-EM
^‡Olingan bozordan
Klinik sinovlar:
- ^†III bosqich
- ^§Hech qachon III bosqichga

O'sish omili retseptorlari modulyatorlar

Agonistlar: Angiopoietin 1
Angiopoietin 4

Antagonistlar: Angiopoietin 2
Angiopoietin 3

Kinaz inhibitörleri: Altiratinib
Idoralar-245677
Rebastinib

Antikorlar: Evinakumab (angiopoietin 3 ga qarshi)
Nesvakumab (angiopoietin 2 ga qarshi)

Agonistlar: Aksokin
CNTF
Dapiclermin

EGF (ErbB1 / HER1)	Agonistlar: Amfiregulin Betatsellulin EGF (urogastron) Epigen Epiregulin Geparin bilan bog'laydigan EGFga o'xshash o'sish omili (HB-EGF) Murodermin Nepidermin O'zgaruvchan o'sish faktori alfa (TGFa) Kinaz inhibitörleri: Afatinib AG-490 Agerafenib Brigatinib Kanertinib Dakomitinib Erlotinib Gefitinib Grandinin Ikotinib Lapatinib Neratinib Osimertinib Vandetanib WHI-P 154 Antikorlar: Cetuximab Depatuxizumab Depatuxizumab mafodotin Futuximab Imgatuzumab Matuzumab Necitumumab Nimotuzumab Panitumumab Zalutumumab
ErbB2 / HER2	Agonistlar: Noma'lum / yo'q Antikorlar: Ertumaxomab Pertuzumab Trastuzumab Trastuzumab duokarmazin Trastuzumab emtansin Kinaz inhibitörleri: Afatinib AG-490 Lapatinib Mubritinib Neratinib Tukatinib
ErbB3 / HER3	Agonistlar: Neuregulinlar (bugulinlar) (1, 2, 6 (neyroglikan C)) Antikorlar: Duligotumab Patritumab Seribantumab
ErbB4 / HER4	Agonistlar: Betatsellulin Epigen Geparin bilan bog'laydigan EGFga o'xshash o'sish omili (HB-EGF) Neuregulinlar (bugulinlar) (1, 2, 3, 4, 5 (tomoregulin, TMEFF))

FGFR1	Agonistlar: Ersofermin FGF (1, 2 (bFGF), 3, 4, 5, 6, 8, 10 (KGF2), 20) Repifermin Selperkatinib Trafermin Velafermin
FGFR2	Agonistlar: Ersofermin FGF (1, 2 (bFGF), 3, 4, 5, 6, 7 (KGF), 8, 9, 10 (KGF2), 17, 18, 22) Palifermin Repifermin Selperkatinib Sprifermin Trafermin Antikorlar: Aprutumab Aprutumab ixadotin
FGFR3	Agonistlar: Ersofermin FGF (1, 2 (bFGF), 4, 8, 9, 18, 23) Selperkatinib Sprifermin Trafermin Antikorlar: Burosumab (FGF23 ga qarshi)
FGFR4	Agonistlar: Ersofermin FGF (1, 2 (bFGF), 4, 6, 8, 9, 19) Trafermin
Saralanmagan	Agonistlar: FGF15 / 19

Agonistlar: Gepatotsitlarning o'sish omili

Potensatorlar: Dihexa (PNB-0408)

IGF-1	Agonistlar: des (1-3) IGF-1 Insulinga o'xshash o'sish omili-1 (somatomedin C) IGF-1 LR3 Insulinga o'xshash o'sish omili-2 (somatomedin A) Insulin Mekazermin Mecasermin rinfabate Kinaz inhibitörleri: BMS-754807 Linsitinib NVP-ADW742 NVP-AEW541 OSl-906 Antikorlar: AVE-1642 Cixutumumab Dalotuzumab Figitumumab Ganitumab Robatumumab R1507 Teprotumumab Xentuzumab (IGF-1 va IGF-2 ga qarshi)
IGF-2	Agonistlar: Insulinga o'xshash o'sish omili-2 (somatomedin A) Antikorlar: Dusigitumab Xentuzumab (IGF-1 va IGF-2 ga qarshi)
Boshqalar	Majburiy oqsillar: IGFBP (1, 2, 3, 4, 5, 6, 7) Noma'lum maqsadli parchalanish mahsulotlari / hosilalari: Glypromat (GPE, (1-3) IGF-1) Trofinetid

LNGF (p75.)^NTR)

Antikorlar: NGFga qarshi: ABT-110 (PG110)
ASP-6294
Fasinumab
Frunevetmab
Fulranumab
MEDI-578
Ranevetmab
Tanezumab

Aptamerlar: NGFga qarshi: RBM-004

Aldangan retseptorlari: LEVI-04 (p75.)^NTR-Fc)

Agonistlar: Bekaplermin
Trombotsitlardan kelib chiqqan o'sish omili (A, B, C, D.)

GFRa1	Agonistlar: Glial hujayra chizig'idan kelib chiqqan neyrotrofik omil (GDNF) Liatermin Kinaz inhibitörleri: Vandetanib
GFRa2	Agonistlar: Neyturin (NRTN) Kinaz inhibitörleri: Vandetanib
GFRa3	Agonistlar: Artemin (ARTN) Kinaz inhibitörleri: Vandetanib
GFRa4	Agonistlar: Persefin (PSPN) Kinaz inhibitörleri: Vandetanib
Saralanmagan	Kinaz inhibitörleri: Agerafenib

SCF (c-to'plam)

Agonistlar: Qadimgi
Ildiz hujayrasi omili

Qarang Bu yerga o'rniga.

TrkA	Agonistlar: Amitriptilin BNN-20 BNN-27 Cenegermin DHEA DHEA-S Gambogik amid NGF Tavilermid Antagonistlar: ALE-0540 Deksametazon FX007 Testosteron Salbiy allosterik modulyatorlar: VM-902A Kinaz inhibitörleri: Altiratinib AZD-6918 Idoralar-245677 CH-7057288 DS-6051 Entrektinib GZ-389988 K252a Larotrektinib Lestaurtinib Milciclib ONO-4474 ONO-5390556 PLX-7486 Rebastinib SNA-120 (pegillangan K252a)) Antikorlar: TrkA-ga qarshi: GBR-900; NGFga qarshi: ABT-110 (PG110) ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamerlar: NGFga qarshi: RBM-004 Aldangan retseptorlari: ReN-1820 (TrkAd5)
TrkB	Agonistlar: 3,7-DHF 3,7,8,2'-THF 4'-DMA-7,8-DHF 7,3'-DHF 7,8-DHF 7,8,2'-THF 7,8,3'-THF Amitriptilin BDNF BNN-20 Dezoksedunin Deprenil Diosmetin DMAQ-B1 XIOC LM22A-4 N-asetilserotonin NT-3 NT-4 Norvogonin (5,7,8-THF) R7 R13 TDP6 Antagonistlar: ANA-12 Tsiklotraksin B Gossipetin (3,5,7,8,3 ', 4'-HHF) Ligandlar: DHEA Kinaz inhibitörleri: Altiratinib AZD-6918 Idoralar-245677 CH-7057288 DS-6051 Entrektinib GZ-389988 K252a Larotrektinib Lestaurtinib ONO-4474 ONO-5390556 PLX-7486
TrkC	Agonistlar: BNN-20 DHEA NT-3 Kinaz inhibitörleri: Altiratinib AZD-6918 Idoralar-245677 CH-7057288 DS-6051 Entrektinib GZ-389988 K252a Larotrektinib Lestaurtinib ONO-4474 ONO-5390556 PLX-7486

Agonistlar: Plasentaning o'sish omili (PGF)
Ripretinib
Telbermin
VEGF (A, B, C, D (FIGF))

Allosterik modulyatorlar: Tsiklotraksin B

Aldangan retseptorlari: Aflibertsept

Boshqalar

O'sishning qo'shimcha omillari: Adrenomedullin
Koloniyani stimulyatsiya qiluvchi omillar (qarang Bu yerga o'rniga)
Birlashtiruvchi to'qima o'sish faktori (CTGF)
Efrinlar (A1, A2, A3, A4, A5, B1, B2, B3)
Eritropoetin (qarang Bu yerga o'rniga)
Glyukoza-6-fosfat izomeraza (GPI; PGI, PHI, AMF)
Glia pishib etish koeffitsienti (GMF)
Gepatomadan kelib chiqqan o'sish omili (HDGF)
Interleykinlar/T hujayralarining o'sish omillari (qarang Bu yerga o'rniga)
Leykemiya inhibitori omili (LIF)
Makrofagni stimulyatsiya qiluvchi oqsil (MSP; HLP, HGFLP)
Midkine (NEGF2)
Migratsiyani stimulyatsiya qiluvchi omil (MSF; PRG4)
Onkomodulin
Gipofiz adenilat siklazni faollashtiradigan peptid (PACAP)
Pleiotrofin
Renalaza
Trombopoetin (qarang Bu yerga o'rniga)
Belgilangan oqsillar

Qo'shimcha o'sish omili retseptorlari modulyatorlari: Cerebrolysin (neyrotrofin aralashmasi)

Shuningdek qarang: Retseptor / signalizatsiya modulyatorlari; Signal peptid / oqsil retseptorlari modulyatorlari; Sitokin retseptorlari modulyatorlari

Bu monoklonal antikor- tegishli maqola a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.

Bu antineoplastik yoki immunomodulyatsion dori maqola a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.