WikiDer > Spiraprilat

Spiraprilat
Identifikatorlar
	IUPAC nomi (8S)-7-[(2S)-2-{[(1S) -1-karboksi-3-fenilpropil] amino} propanoyl] -1,4-ditiya-7-azaspiro [4.4] nonan-8-karboksilik kislota;
CAS raqami	83602-05-5 ;
PubChem CID	3033702;
IUPHAR / BPS	6576;
ChemSpider	2298317;
UNII	QS56V5Y7EC;
ChEBI	CHEBI: 141522;
ChEMBL	ChEMBL579;
CompTox boshqaruv paneli (EPA)	DTXSID30232453 ;
Kimyoviy va fizik ma'lumotlar
Formula	C20H26N2O5S2
Molyar massa	438.56 g · mol−1
3D model (JSmol)	Interaktiv rasm;
	Jilmayganlar C [C @ H] (N [C @@ H] (CCc1ccccc1) C (= O) O) C (= O) N2CC3 (C [C @ H] 2C (= O) O) SCCS3;
	InChI InChI = 1S / C20H26N2O5S2 / c1-13 (21-15 (18 (24) 25) 8-7-14-5-3-2-4-6-14) 17 (23) 22-12-20 (28-) 9-10-29-20) 11-16 (22) 19 (26) 27 / h2-6,13,15-16,21H, 7-12H2,1H3, (H, 24,25) (H, 26, 27) / t13-, 15-, 16- / m0 / s1; Kalit: FMMDBLMCSDRUPA-BPUTZDHNSA-N;

Spiraprilat

Spiraprilat bo'ladi faol metabolit ning spirapril.^[1]

Adabiyotlar

^ Noble S, Sorkin EM (1995 yil may). "Spirapril. Gipertenziyani davolashda uning farmakologiyasi va terapevtik samaradorligini dastlabki ko'rib chiqish". Giyohvand moddalar. 49 (5): 750–66. doi:10.2165/00003495-199549050-00008. PMID 7601014.

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v t e Anjiyotensin retseptorlari modulyatorlar
ATR	Agonistlar: Angiotensin II Angiotensin III Angiotensin IV L-163,491 Saralasin Antagonistlar: Abitesartan Azilsartan Kandesartan Elisartan Embusartan Eprosartan EXP-3174 Fimasartan Forasartan Irbesartan Losartan Milfasartan Olmesartan Olodanrigan PD123319 Pomisartan Pratosartan Ripisartan Saprisartan Sparsentan Tasosartan Telmisartan Valsartan Zolasartan ACE inhibitörler: Alatsepril Benazepril Captopril Silazapril Delapril Enalapril Enalaprilat Fosinopril Gemopatrilat Imidapril Lisinopril Moeksipril Omapatrilat Perindopril Quinapril Kinaprilat Ramipril Rentiapril Rescinnamine Spirapril Spiraprilat Temokapril Trandolapril Zofenopril Zofenoprilat Renin inhibitörleri: Aliskiren Ciprokiren Ditekiren Enalkiren Imarikiren Pepstatin Remikiren Terlakiren Zankiren Propeptidlar: Anjiyotensinogen Angiotensin I
Kombinatsiyalar:	Amlodipin / valsartan Olmesartan / amlodipin Olmesartan / amlodipin / gidroxlorotiyazid Valsartan / gidroxlorotiyazid Valsartan / gidroxlorotiyazid / amlodipin
Shuningdek qarang Retseptor / signalizatsiya modulyatorlari Signal peptid / oqsil retseptorlari modulyatorlari

Identifikatorlar

IUPAC nomi (8S)-7-[(2S)-2-{[(1S) -1-karboksi-3-fenilpropil] amino} propanoyl] -1,4-ditiya-7-azaspiro [4.4] nonan-8-karboksilik kislota
CAS raqami	83602-05-5^Y
PubChem CID	3033702
IUPHAR / BPS	6576
ChemSpider	2298317
UNII	QS56V5Y7EC
ChEBI	CHEBI: 141522
ChEMBL	ChEMBL579
CompTox boshqaruv paneli (EPA)	DTXSID30232453
Kimyoviy va fizik ma'lumotlar
Formula	C₂₀H₂₆N₂O₅S₂
Molyar massa	438.56 g · mol⁻¹
3D model (JSmol)	Interaktiv rasm
Jilmayganlar C [C @ H] (N [C @@ H] (CCc1ccccc1) C (= O) O) C (= O) N2CC3 (C [C @ H] 2C (= O) O) SCCS3
InChI InChI = 1S / C20H26N2O5S2 / c1-13 (21-15 (18 (24) 25) 8-7-14-5-3-2-4-6-14) 17 (23) 22-12-20 (28-) 9-10-29-20) 11-16 (22) 19 (26) 27 / h2-6,13,15-16,21H, 7-12H2,1H3, (H, 24,25) (H, 26, 27) / t13-, 15-, 16- / m0 / s1 Kalit: FMMDBLMCSDRUPA-BPUTZDHNSA-N