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Pirbuterol

Pirbuterol
Klinik ma'lumotlar

Savdo nomlari	Maxair
AHFS/Drugs.com	Iste'molchilarning giyohvand moddalari haqida ma'lumot
MedlinePlus	a601096
Homiladorlik toifasi	C
Marshrutlari ma'muriyat	Nafas olish (MDI)
ATC kodi	R03AC08 (JSSV) R03CC07 (JSSV)
Huquqiy holat
Huquqiy holat	BIZ: ℞-faqat
Identifikatorlar
IUPAC nomi (RS)-6-[2-(tert-butilamino) -1-gidroksietil] -2- (gidroksimetil) piridin-3-ol
CAS raqami	38029-10-6^N
PubChem CID	4845
IUPHAR / BPS	7272
DrugBank	DB01291^Y
ChemSpider	4679^Y
UNII	OG645J8RVW
KEGG	D08387^N
ChEMBL	ChEMBL1094966^Y
CompTox boshqaruv paneli (EPA)	DTXSID0046937
Kimyoviy va fizik ma'lumotlar
Formula	C₁₂H₂₀N₂O₃
Molyar massa	240.303 g · mol⁻¹
3D model (JSmol)	Interaktiv rasm
Chirallik	Rasemik aralashmasi
Jilmayganlar Oc1ccc (nc1CO) C (O) CNC (C) (C) C
InChI InChI = 1S / C12H20N2O3 / c1-12 (2,3) 13-6-11 (17) 8-4-5-10 (16) 9 (7-15) 14-8 / h4-5,11,13, 15-17H, 6-7H2,1-3H3^Y Kalit: VQDBNKDJNJQRDG-UHFFFAOYSA-N^Y
^NY (bu nima?) (tasdiqlash)

Pirbuterol (savdo nomi) Maxair) qisqa muddatli β₂ adrenoreseptor agonisti bilan bronxodilatatsion davolashda ishlatiladigan harakat Astma, mavjud (pirbuterol asetat kabi) nafas olish bilan faollashtirilgan dozalangan inhaler.

U 1971 yilda patentlangan va 1983 yilda tibbiy foydalanishga kiritilgan.^[1]

Tibbiy maqsadlarda foydalanish

Pirbuterol astma kasalligida o'tkirni qaytarish uchun ishlatiladi bronxospazm, shuningdek, kelajakdagi hujumlarning oldini olish uchun parvarishlash vositasi sifatida. U 12 yosh va undan katta yoshdagi bemorlarga bir vaqtda yoki u bilan birga qo'llanilishi kerak teofillin va / yoki nafas olish kortikosteroid.^[2]^[3]

Faoliyat tartibi

Farmakokinetikasi

Nafas olishdan keyin 800 gacha mg (tavsiya etilgan maksimal dozadan ikki baravar) pirbuterolning tizimli qon darajasi tahlil sezuvchanligi chegarasidan past (2-5 ng / ml). Dozaning o'rtacha 51% ni siydikda pirbuterol va uning sulfat konjugati sifatida aerozol yuborilgandan so'ng qaytarib olinadi. Pirbuterol metabolizmga uchramaydi katekol-O-metiltransferaza. Og'iz orqali qabul qilinganidan keyin o'lchangan plazmadagi yarim umr taxminan ikki soatni tashkil qiladi.^[2]

Yomon ta'sir

Adabiyotlar

^ Fischer J, Ganellin CR (2006). Analog asosida giyohvand moddalarni kashf etish. John Wiley & Sons. p. 543. ISBN 9783527607495.
^ ^a ^b "Maxair Autohaler (pirbuterol asetat inhalation aerosol) Faqat og'iz orqali nafas olish uchun. AQShning to'liq retsept bo'yicha ma'lumoti". 3M farmatsevtika. Northridge, CA 91324. Arxivlangan asl nusxasi 2018 yil 20 sentyabrda. Olingan 7 mart 2016.
^ Byanki M, Klavenna A, Bonati M (sentyabr 2010). "Bolalar uchun astmatik dori-darmonlarni tayinlash bo'yicha mamlakatlararo farqlar. 2000-2009 yillarda nashr etilgan tadqiqotlarni tizimli ko'rib chiqish" (PDF). Evropa klinik farmakologiya jurnali. 66 (9): 929–36. doi:10.1007 / s00228-010-0845-y. PMID 20533030. S2CID 21834280.

Tashqi havolalar

RxList: Maxair (Pirbuterol)

v t e Adrenergik retseptorlari modulyatorlar
a₁	Agonistlar: 6-FNE Amidefrin Anizodin Buspirone Sirazolin Korbadrin Desglimidodrin Deksizometeptene Dipivefrin Dopamin Droksidopa (L-DOPS) Efedrin Epinefrin Etilefrin Etilevodopa Etilnorepinefrin Indanidin Izometheptene L-DOPA (levodopa) L-Fenilalanin L-Tirozin Melevodopa Metaraminol Metoksamin Metildopa Midodrin Nafazolin Norepinefrin Ahtapamin Oksimetazolin Fenilefrin Fenilpropanolamin Psödoefedrin Sinefrin Tetrizolin Tiamenidin XP21279 Ksilometazolin Antagonistlar: Abanquil Adimolol Ajmalitsin Alfuzosin Amosulalol Anizodamin Arotinolol Atiprosin Atipik antipsikotiklar (masalan, brekspiprazol, klozapin, olanzapin, ketiapin, risperidon) Benoksatian Buflomedil Bunazosin Carvedilol Korynantin Dapiprazol Mahalliy Doksazosin Ergolines (masalan, ergotamin, dihidroergotamin, lisurid, tergurid) Etoperidon Evgenodilol Fenspirid Gidroksizin Indoramin Ketanserin L-765,314 Labetalol mCPP Mepiprazol Metazosin Monatepil Moksisilit Naftopidil Nantenin Neldazosin Niaprazin Nikergolin Niguldipine Pardoprunoks Pelanserin Perlapin Phendioxan Fenoksibenzamin Fentolamin Fenilpiperazin antidepressantlar (masalan, gidroksifazodon, nefazodon, trazodon, triazoledion) Piperoksan Prazosin Kinazosin Kinidin Ritanserin Silodosin Spiperon Talipeksol Tamsulosin Terazosin Tiodazosin Tolazolin Tetratsiklik antidepressantlar (masalan, amoksapin, maprotilin, mianserin) Trisiklik antidepressantlar (masalan, amitriptilin, klomipramin, doksepin, imipramin, trimipramin) Trimazosin Odatda antipsikotiklar (masalan, xlorpromazin, flüfenazin, loxapin, tioridazin) Urapidil WB-4101 Zolertin
a₂	Agonistlar: (R) -3-nitrobifenilin 4-NEMD 6-FNE Amitraz Apraklonidin Brimonidin Kannabivarin Klonidin Korbadrin Detomidin Deksmedetomidin Dihidroergotamin Dipivefrin Dopamin Droksidopa (L-DOPS) Etilevodopa Efedrin Ergotamin Epinefrin Etilefrin Etilnorepinefrin Guanabenz Guanfasin Guanoksabenz L-DOPA (levodopa) L-Fenilalanin L-Tirozin Lofexidin Medetomidin Melevodopa Metildopa Mivazerol Nafazolin Norepinefrin Oksimetazolin Fenilpropanolamin Piperoksan Psödoefedrin Rezatomidin Rilmenidin Romifidin Talipeksol Tasipimidin Tetrahidrozolin Tiamenidin Tizanidin Tolonidin Urapidil Vatinoksan XP21279 Ksilazin Ksilometazolin Antagonistlar: 1-PP Adimolol Amesergid Aptazapin Atipamezol Atipik antipsikotiklar (masalan, asenapin, brekspiprazol, klozapin, lurasidon, olanzapin, paliperidon, ketiapin, risperidon, zotepin) Azapironlar (masalan, buspirone, gepiron, ipsapirone, tandospiron) BRL-44408 Buflomedil Sirazolin Efaroksan Esmirtazapin Fenmetozol Fluparoksan Idazoksan mCPP Mianserin Mirtazapin NAN-190 Pardoprunoks Fentolamin Fenoksibenzamin Piperoksan Piribedil Rawolscine Rotigotin SB-269970 Setiptiline Spiroksatrin Sunepitron Tolazolin Odatda antipsikotiklar (masalan, xlorpromazin, flüfenazin, loxapin, tioridazin) Yohimbine
β	Agonistlar: Abediterol Alifedrin Amibegron Arbutamin Arformoterol Arotinolol BAAM Bambuterol Befunolol Bitolterol Broksaterol Bupenin Karbuterol Karmoterol Cimaterol Klenbuterol Kolterol Korbadrin Denopamin Dipivefrin Dobutamin Dopamin Dopeksamin Droksidopa (L-DOPS) Efedrin Epinefrin Etafedrin Etilefrin Etilevodopa Etilnorepinefrin Fenoterol Formoterol Geksoprenalin Higenamin Indakaterol Isoetarin Izoprenalin Isoxsuprin L-DOPA (levodopa) L-Fenilalanin L-Tirozin Levosalbutamol Mabuterol Melevodopa Metoksifenamin Metildopa Mirabegron Norepinefrin Orsiprenalin Oksifedrin PF-610355 Fenilpropanolamin Pirbuterol Prenalterol Raktopamin Prokaterol Psödoefedrin Reproterol Rimiterol Ritodrin Salbutamol Salmeterol Solabegron Terbutalin Tretoxinol Tulobuterol Vilanterol Xamoterol XP21279 Zilpaterol Zinterol Antagonistlar: Asebutolol Adaprolol Adimolol Afurolol Alprenolol Alprenoksim Amosulalol Ancarolol Arnolol Arotinolol Atenolol Befunolol Betaxolol Bevantolol Bisoprolol Bopindolol Bornaprolol Brefonalol Bucindolol Bucumolol Bufetolol Bufuralol Bunitrolol Bunolol Bupranolol Butaksamin Butidrin Butofilolol Kapsinolol Karazolol Karpindolol Karteolol Carvedilol Celiprolol Setamolol Tsikloprolol Cinamolol Kloranol Siyanopindolol Dalbraminol Dexpropranolol Diatsetolol Dikloroizoprenalin Dihidroalprenolol Dilevalol Diprafenon Drakinolol Ecastolol Epanolol Erikolol Ersentilid Esatenolol Esprolol Evgenodilol Exaprolol Falintolol Flestolol Flusoksolol Gidroksikarteolol Gidroksistertolol ICI-118,551 Idropranolol Indenolol Indopanolol Iodosiyanopindolol Iprokrolol Isoxaprolol Isamoltan Labetalol Landiolol Levobetaxolol Levobunolol Levomoprolol Medroxalol Mepindolol Metipranolol Metoprolol Moprolol Nadolol Nadoksolol Nebivolol Nifenalol Nipradilol Oksprenolol Pakrinolol Pafenolol Pamatolol Pargolol Penbutolol Pindolol Practolol Primidolol Protsinolol Pronetalol Propafenon Propranolol Ridazolol Ronaktolol Soquinolol Sotalol Spirendolol SR 59230A Sulfinalol Talinolol Tazolol Tertatolol Tienoksolol Tilisolol Timolol Tiprenolol Tolamolol Toliprolol Xibenolol Xipranolol
Qarang shuningdek	Adrenerjik dorilar ro'yxati

Giyohvand moddalar obstruktiv havo yo'li kasalliklari: Astma/KOAH (R03)

Adrenerjiklar, nafas olish

Qisqa muddatli β₂ agonistlar	Bitolterol Karbuterol Fenoterol Isoetarin Pirbuterol Prokaterol Reproterol Rimiterol Salbutamol (albuterol)^#/Levosalbutamol (levalbuterol) Terbutalin Tulobuterol
Uzoq muddatli β₂ agonistlar	Bambuterol Klenbuterol Formoterol/Arformoterol Salmeterol Salmefamol
Ultra uzoq muddatli β₂ agonistlar	Abediterol Karmoterol Indakaterol Olodaterol Vilanterol
Boshqalar	Epinefrin^# Geksoprenalin Izoprenalin (izoproterenol) Orciprenaline (metaproterenol)

Glyukokortikoidlar

Antikolinerjiklar/
muskarinik antagonist

Mast hujayralari stabilizatorlari

Ksantinlar

Eikosanoid inhibisyon

Leykotrien antagonistlari	Montelukast Pranlukast Zafirlukast
Araxidonat 5-lipoksigenaza inhibitörleri	Zileuton
Tromboksan retseptorlari antagonistlari	Ramatroban Seratrodast
Ksantin bo'lmagan PDE4 inhibitörleri	Ibudilast Roflumilast

Boshqalar / noma'lum

Kombinatsiyalangan mahsulotlar

^#JSST-EM
^‡Olingan bozordan
Klinik sinovlar:
- ^†III bosqich
- ^§Hech qachon III bosqichga

v t e Fenetilaminlar
Fenetilaminlar	Psixelika: 25B-NBOMe 25C-NBOMe 25D-NBOMe 25I-NBOMe 25N-NBOMe 2C-B 2C-B-AN 2C-Bn 2C-Bu 2C-C 2C-CN 2C-CP 2C-D 2C-E 2C-EF 2C-F 2C-G 2C-G-1 2C-G-2 2C-G-3 2C-G-4 2C-G-5 2C-G-6 2C-G-N 2C-H 2C-I 2C-iP 2C-N 2C-NH2 2C-O 2C-O-4 2C-P 2C-Ph 2C-SE 2C-T 2C-T-2 2C-T-3 2C-T-4 2C-T-5 2C-T-6 2C-T-7 2C-T-8 2C-T-9 2C-T-10 2C-T-11 2C-T-12 2C-T-13 2C-T-14 2C-T-15 2C-T-16 2C-T-17 2C-T-18 2C-T-19 2C-T-20 2C-T-21 2C-T-22 2C-T-22.5 2C-T-23 2C-T-24 2C-T-25 2C-T-27 2C-T-28 2C-T-30 2C-T-31 2C-T-32 2C-T-33 2C-TFE 2C-TFM 2C-YN 2C-V Allyselkalin DESOKSI Eskalin Izoproskalin Jimkalin Makromerin MEPEA Meskalin Meteskalin Metalleskalin Proskalin Psi-2C-T-4 TCB-2 Venlafaksin Stimulyatorlar: Feniletanolamin Hordenine Fenetilamin a-metilfenetilamin (amfetamin) b-metilfenetilamin m-Metilfenetilamin N-Metilfenetilamin o-Metilfenetilamin p-Metilfenetilamin Metilfenidat Entaktogenlar: Lopofin MDPEA MDMPEA Boshqalar: BOH DMPEA
Amfetaminlar	Psixelika: 3C-BZ 3C-E 3C-P Alef Beatris Bromo-DragonFLY D-Deprenil DMA DMCPA DMMDA DOB DOC DOEF DOET DOI DOM DON DOPR DOTFM Ganesha MMDA MMDA-2 Psi-DOM TMA TeMA Stimulyatorlar: 2-FA 2-FMA 3-FA 3-FMA Acridorex Alfetamin Amfekloral Amfepentorex Amfetamin (Dekstroamfetamin, Levoamfetamin) Amfetaminil Benfloreks Benzfetamin Ketin Klobenzoreks Dimetilamfetamin Efedrin Etilamfetamin Fencamfamin Fenkamin Fenetillin Fenfluramin (Dexfenfluramin, Levofenfluramin) Fenproporeks Flucetorex Fludoreks Formetorex Furfenoreks Gefefrin 4-gidroksiamfetamin Iofetamin Izopropilamfetamin Lefetamin Lisdexamfetamin Mefenorex Metaraminol Metamfetamin (Dekstrometamfetamin, Levometamfetamin) Metoksifenamin MMA Morforex Norfenfluramin L -Norsevdoefedrin N, alfa-dietilfeniletilamin Oxifentorex Oksilofrin Ortetamin PBA PCA Fenprometamin PFA PFMA PIA PMA PMEA PMMA Fenilpropanolamin Fledrin Prenilamin Propilamfetamin Psödoefedrin Sibutramin Tifloreks Tranilsipromin Ksilopropamin Zilofuramin Entaktogenlar: 4-FA 4-FMA 4-MA 4-MMA 4-MTA 5-APB 5-APDB 5-EAPB 5-IT 5-MAPB 5-MAPDB 6-APB 6-APDB 6-Xloro-MDMA 6-EAPB 6-IT 6-MAPB 6-MAPDB EDA IAP 2,3-MDA 3,4-MDA (tenamfetamin) MDEA MDHMA MDMA (midomafetamin) MDOH Metamnetamin MMDMA Naftilaminopropan TAP Boshqalar: 3,4-DCA Amiflamin DiFMDA Selegilin (shuningdek D. -Deprenil)
Fenterminalar	Stimulyatorlar: Xlorfentermin Cloforex Klortermin Etolorex Mefentermin Pentorex Phentermine Entaktogenlar: MDPH MDMPH Boshqalar: Seriklamin
Katinonlar	Stimulyatorlar: 3-FMC 4-MC 4-BMC 4-CMC 4-EMC 4-FMC 4-MEC 4-MeMABP 4-MPD Amfepramon Benzedron Brephedron Bufedron Bupropion Katinon Dimetilkatinon Etkatinon Evtilon Gidroksibupropion Metkatinon Methedron NEB N-etilheksedron N-etilpentrone Pentrone Pentilon Radafaksin Entaktogenlar: 3,4-DMMC 3-MMC Butilon Etilon Metilon Metilenedioksikatinon Mefedron
Fenilizobutilaminlar	Entaktogenlar: 4-CAB 4-MAB Ariadne BDB Butilon EBDB Evtilon MBDB Stimulyatorlar: Fenilizobutilamin
Fenilalkilpirrolidinlar	Stimulyatorlar: a-PBP a-PHP a-PPP a-PVP MDPBP MDPPP MDPV 4-MePBP 4-MePHP 4-MePPP MOPPP MOPVP MPBP MPHP MPPP Nafiron PEP Prolintan Pirovaleron
Katekolaminlar (va yaqin qarindoshlari)	6-FNE 6-OHDA a-Me-DA a-Me-TRA Adrenoxrom Siladopa D. -DOPA (Dekstrodopa) Dimetofrin Dopamin Epinefrin Epinin Etilefrin Etilnorepinefrin Fenklonin Ibopamin Izoprenalin Isoetarin L -DOPA (Levodopa) L -DOPS (Droksidopa) L -Fenilalanin L -Tirozin m-Tiramin Metanefrin Metaraminol Metaterol Metirozin Metildopa N, N-dimetildopamin Nordefrin (Levonordefrin) Norepinefrin Norfenefrin (m-Oktopamin) Normetanephrine Orsiprenalin p-Oktopamin p-Tiramin Fenilefrin Sinefrin
Turli xil	AL-LAD Amidefrin Arbutamin Kafedrin Denopamin Desvenlafaksin Difenidin Dizosilpin Dobutamin Dopeksamin Efenidin Etafedrin ETH-LAD Famprofazon Ftorolintan Geksapradol IP-LAD Lizerjik kislota amidi Liserjik kislota 2-butil amid Lizerjik kislota 2,4-dimetilazetidid Lizerjik kislota dietilamid Metoksamin Metoksfenidin MT-45 PARGY-LAD Phenibut PRO-LAD Pronetalol Salbutamol (Levosalbutamol) Solriamfetol Teodrenalin Tiamfenikol UWA-101

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