WikiDer > CGS-12066A

CGS-12066A
Identifikatorlar
	IUPAC nomi 4- (4-metilpiperazin-1-il) -7- (triflorometil) pirrolo [1,2-a] kinoksalin;
CAS raqami	109028-10-6 ;
PubChem CID	2689;
IUPHAR / BPS	109;
ChemSpider	2588 ;
UNII	VJ9I4R0C0C;
CompTox boshqaruv paneli (EPA)	DTXSID3043730 ;
Kimyoviy va fizik ma'lumotlar
Formula	C17H17F3N4
Molyar massa	334.346 g · mol−1
3D model (JSmol)	Interaktiv rasm;
	Jilmayganlar C3CN (C) CCN3c2nc1cc (C (F) (F) F) ccc1n4cccc24;
	InChI InChI = 1S / C17H17F3N4 / c1-22-7-9-23 (10-8-22) 16-15-3-2-6-24 (15) 14-5-4-12 (17 (18,19)) 20) 11-13 (14) 21-16 / h2-6,11H, 7-10H2,1H3 ; Kalit: LXFHSCDLMBZYKY-UHFFFAOYSA-N ;
	(bu nima?) (tasdiqlash)

CGS-12066A

CGS-12066A a dori sifatida ishlaydi kuchli va tanlangan agonist uchun 5-HT_1B retseptorlari uchtaga nisbatan pastroq yaqinlik bilan 5-HT₂ retseptorlari subtiplari.^[1]^[2] U 5-HT rolini o'rganish uchun ishlatiladi_1B turli jarayonlarda retseptor, og'riqni his qilish va uyquni uyg'otish tsikli.^[3]^[4]

Adabiyotlar

^ Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M (Avgust 2004). "5-HT (2A), 5-HT (2B) va 5-HT (2C) retseptorlarining agonist radioligand bog'lanish joyining farmakologik tavsifi". Naunin-Shmiedebergning farmakologiya arxivi. 370 (2): 114–23. doi:10.1007 / s00210-004-0951-4. PMID 15322733. S2CID 8938111.
^ Jeong HS, Jang MJ, Park JS (mart 2005). "CGS-12066A ning medial vestibulyar yadro neyronlariga ta'siri". Miya tadqiqotlari. 1038 (1): 118–21. doi:10.1016 / j.brainres.2005.01.025. PMID 15748881. S2CID 22734919.
^ Monti JM, Jantos H (2008). "Dopamin va serotonin va ularning retseptorlari, uyquni va uyg'onishni tartibga solishda". Miya tadqiqotida taraqqiyot. 172: 625–46. doi:10.1016 / S0079-6123 (08) 00929-1. ISBN 9780444532350. PMID 18772053.
^ Granados-Soto V, Argüelles CF, Rocha-Gonsales HI, Godínez-Chaparro B, Flores-Murrieta FJ, Villalón CM (yanvar 2010). "Sichqonlarda nosiseptsiyani kamaytirishda periferik 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E va 5-HT1F serotonerjik retseptorlarining roli". Nevrologiya. 165 (2): 561–8. doi:10.1016 / j.neuroscience.2009.10.020. PMID 19837141. S2CID 195684404.

Bu dori ga tegishli maqola asab tizimi a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.

[1] Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M (Avgust 2004). "5-HT (2A), 5-HT (2B) va 5-HT (2C) retseptorlarining agonist radioligand bog'lanish joyining farmakologik tavsifi". Naunin-Shmiedebergning farmakologiya arxivi. 370 (2): 114–23. doi:10.1007 / s00210-004-0951-4. PMID 15322733. S2CID 8938111.

[2] Jeong HS, Jang MJ, Park JS (mart 2005). "CGS-12066A ning medial vestibulyar yadro neyronlariga ta'siri". Miya tadqiqotlari. 1038 (1): 118–21. doi:10.1016 / j.brainres.2005.01.025. PMID 15748881. S2CID 22734919.

[3] Monti JM, Jantos H (2008). "Dopamin va serotonin va ularning retseptorlari, uyquni va uyg'onishni tartibga solishda". Miya tadqiqotida taraqqiyot. 172: 625–46. doi:10.1016 / S0079-6123 (08) 00929-1. ISBN 9780444532350. PMID 18772053.

[4] Granados-Soto V, Argüelles CF, Rocha-Gonsales HI, Godínez-Chaparro B, Flores-Murrieta FJ, Villalón CM (yanvar 2010). "Sichqonlarda nosiseptsiyani kamaytirishda periferik 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E va 5-HT1F serotonerjik retseptorlarining roli". Nevrologiya. 165 (2): 561–8. doi:10.1016 / j.neuroscience.2009.10.020. PMID 19837141. S2CID 195684404.

[1]

[2]

[3]

[4]

v t e Piperazinlar
Oddiy piperazinlar (qo'shimcha qo'ng'iroqlar yo'q)	1-sikloheksilpiperazin Aminoetilpiperazin Dietilkarbamazin GES Midafotel Piperazin QUPLAR
Fenilpiperazinlar	2C-B-PP 3,4-CFP Akaprazin Antrafenin Aripiprazol Batoprazin Bifeprunoks BRL-15,572 Siprofloksatsin CSP-2503 Dapiprazol DCPP DMPP Difenilpiperazin Dropropizin EGIS-12,233 Elopiprazol Eltoprazin Enpiprazol Ensakulin Etoperidon Flesinoksan Fluanizon Flibanserin Fluprazin Itrakonazol Ketokonazol Levodropropizin Lorpiprazol mCPP Mefway MeOPP Mepiprazol Naftopidil Naluzotan Naftilpiperazin Nefazodon Niaprazin Oksipertin Pardoprunoks pCPP pFPP Posakonazol S-14,506 FZR 14,671 S-15,535 SB-258,585 SB-271,046 SB-357,134 SB-399,885 Sonepiprazol TFMPP Tolpiprazol Trazodone Urapidil Vesnarinone Vilazodone Vortioksetin Yo'l-100,135 YO'L-100,635
Benzilpiperazinlar	2C-B-BZP 3-metilbenzilpiperazin Befuralin Bifeprunoks Buklizin BZP Xlorbenzoksamin DBZP Fipeksid Imatinib MBZP MDBZP Meklozin Metoksipiperamid Piberalin Piribedil Sunifiram Trimetazidin Vesnarinone
Difenilalkilpiperazinlar (benzhidrilalkilpiperazinlar)	AD-1211 Almitrin Amperozid BRL-15,572 Buklizin BW373U86 Cetirizine Xlorbenzoksamin Xlortsiklizin Sininarizin Klocinizin Siklizin DBL-583 Difenpipenol Difenilmetilpiperazin Dotarizin DPI-221 DPI-287 DPI-3290 GBR-12,783 GBR-12,935 GBR-13,069 GBR-13,098 GBR-13,119 Gidroksizin Lidoflazin Manidipin Meklozin MT-45 Oksatomid SNC-80 Vanokserin
Pirimidinilpiperazinlar	Buspirone Dasatinib Eptapiron Gepirone Ipsapiron Piribedil Praziton Pirimidinilpiperazin Revospiron Tandospiron Tirilazad Trimazosin Umespirone Zalospirone
Piridinilpiperazinlar	Atevirdin Azaperone Delavirdin Mirtazapin Piridinilpiperazin
Benzo (iso) tiazolil piperazinlar	Lurasidon Perospiron Revospiron Tiospiron Ziprasidon
Trisikliklar (yon zanjir orqali biriktirilgan piperazin)	Amoksapin Klopentiksol Klorotepin Klozapin Siyanotepin Dlotlotepin Dokloksitepin Flupentiksol Flüfenazin Izofloksitepin Loksapin Meperatiyepin Metitepin Oktometotepin Olanzapin Opipramol Oksiklotepin Oksiprotepin Peraditiyepin Perathiepin Perazin Perfenazin Pirenzepin Proxlorperazin Tietilperazin Thiothixene Trifluoperazin Triflutepin Zuklopentiksol
Boshqalar / toifalarga kiritilmagan	6-nitrokipazin Azimilid Cinepazet Sinepazik kislota Sinepazid CPD-1 Sikloheksilpiperazin EGIS-7625 Geksotsiklium Indinavir JNJ-7777120 Lodenafil Mirodenafil PB-28 Kipazin Ranolazin SA-4503 Sildenafil Tadalafil Vardenafil VUF-6002 WY-46824 Zipeprol

Navigation

Navigation

Themenportale

WikiDer > CGS-12066A

Adabiyotlar

Identifikatorlar

IUPAC nomi 4- (4-metilpiperazin-1-il) -7- (triflorometil) pirrolo [1,2-a] kinoksalin
CAS raqami	109028-10-6^Y
PubChem CID	2689
IUPHAR / BPS	109
ChemSpider	2588^N
UNII	VJ9I4R0C0C
CompTox boshqaruv paneli (EPA)	DTXSID3043730
Kimyoviy va fizik ma'lumotlar
Formula	C₁₇H₁₇F₃N₄
Molyar massa	334.346 g · mol⁻¹
3D model (JSmol)	Interaktiv rasm
Jilmayganlar C3CN (C) CCN3c2nc1cc (C (F) (F) F) ccc1n4cccc24
InChI InChI = 1S / C17H17F3N4 / c1-22-7-9-23 (10-8-22) 16-15-3-2-6-24 (15) 14-5-4-12 (17 (18,19)) 20) 11-13 (14) 21-16 / h2-6,11H, 7-10H2,1H3^N Kalit: LXFHSCDLMBZYKY-UHFFFAOYSA-N^N
^NY (bu nima?) (tasdiqlash)