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Pirenzepin
Klinik ma'lumotlar
AHFS/Drugs.com	Giyohvand moddalarning xalqaro nomlari
ATC kodi	A02BX03 (JSSV) ;
Identifikatorlar
	IUPAC nomi 11 - [(4-metilpiperazin-1-il) atsetil] -5,11-dihidro-6H-pirido [2,3-b] [1,4] benzodiazepin-6-bir;
CAS raqami	28797-61-7 ;
PubChem CID	4848;
IUPHAR / BPS	328;
DrugBank	DB00670 ;
ChemSpider	4682 ;
UNII	3G0285N20N;
KEGG	D08389 ;
ChEBI	CHEBI: 8247 ;
ChEMBL	ChEMBL9967 ;
CompTox boshqaruv paneli (EPA)	DTXSID7023487 ;
ECHA ma'lumot kartasi	100.044.739
Kimyoviy va fizik ma'lumotlar
Formula	C19H21N5O2
Molyar massa	351.410 g · mol−1
3D model (JSmol)	Interaktiv rasm;
	Jilmayganlar O = C3c1ccccc1N (C (= O) CN2CCN (C) CC2) c4ncccc4N3;
	InChI InChI = 1S / C19H21N5O2 / c1-22-9-11-23 (12-10-22) 13-17 (25) 24-16-7-3-2-5-14 (16) 19 (26) 21- 15-6-4-8-20-18 (15) 24 / h2-8H, 9-13H2,1H3, (H, 21,26) ; Kalit: RMHMFHUVIITRHF-UHFFFAOYSA-N ;
	(tasdiqlash)

Pirenzepine

Pirenzepin (Gastrozepin), an M₁ selektiv antagonist, davolashda ishlatiladi oshqozon yarasi, chunki u kamayadi oshqozon kislotasi sekretsiya va kamaytiradi mushaklarning spazmi. Bu ma'lum bo'lgan dorilar sinfida muskarinik retseptorlari antagonistlari - atsetilxolin neyrotransmitter bo'lish parasempatik asab tizimi u dam olish va hazm qilish holatini boshlaydi (kurash yoki parvozdan farqli o'laroq), natijada oshqozon motilligi va ovqat hazm qilish kuchayadi; pirenzepin esa bu harakatlarni inhibe qiladi va oshqozon harakatining pasayishiga olib keladi, bu esa oshqozonni bo'shatish va ich qotishining kechikishiga olib keladi.^[1] Uning miya va orqa miyaga ta'siri yo'q, chunki u orqali tarqalib bo'lmaydi qon-miya to'sig'i.

Pirenzepin foydalanish uchun tekshirilgan miyopi boshqaruv.^[2]^[3]

Bu homodimerizatsiyani yoki oligomerizatsiya ning M₁ retseptorlari.^[4]

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Adabiyotlar

^ Stolerman IP (2010 yil 2-avgust). Psixofarmakologiya entsiklopediyasi. Springer. p. 811. ISBN 978-3-540-68698-9. Olingan 26 iyun 2013.
^ Czepita D (2005). "[Miyopiyani zamonaviy davolash asoslari]". Annales Academiae Medicae Stetinensis. 51 (2): 5–9. PMID 16519089.
^ Uollin, Jefri J.; Lindsli, Kristina B.; Vedula, S. Svarup; Kotter, Syuzan A .; Mutti, Donald O.; Ng, Sueko M.; Twelker, J. Daniel (13 yanvar 2020). "Bolalardagi miopiya rivojlanishining sekinlashuviga qaratilgan tadbirlar". Tizimli sharhlarning Cochrane ma'lumotlar bazasi. 1: CD004916. doi:10.1002 / 14651858.CD004916.pub4. ISSN 1469-493X. PMC 6984636. PMID 31930781.
^ Pediani JD, Uord RJ, Godin AG, Marsango S, Milligan G (iyun 2016). "M1 muskarinli retseptorlarini to'rtburchak tashkil etilishini subtip-selektiv antagonist dorilar tomonidan dinamik tartibga solish". Biologik kimyo jurnali. 291 (25): 13132–46. doi:10.1074 / jbc.M115.712562. PMC 4933229. PMID 27080256.

Bu dori ga tegishli maqola oshqozon-ichak tizimi a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.

[Stolerman2010-1] Stolerman IP (2010 yil 2-avgust). Psixofarmakologiya entsiklopediyasi. Springer. p. 811. ISBN 978-3-540-68698-9. Olingan 26 iyun 2013.

[2] Czepita D (2005). "[Miyopiyani zamonaviy davolash asoslari]". Annales Academiae Medicae Stetinensis. 51 (2): 5–9. PMID 16519089.

[3] Uollin, Jefri J.; Lindsli, Kristina B.; Vedula, S. Svarup; Kotter, Syuzan A .; Mutti, Donald O.; Ng, Sueko M.; Twelker, J. Daniel (13 yanvar 2020). "Bolalardagi miopiya rivojlanishining sekinlashuviga qaratilgan tadbirlar". Tizimli sharhlarning Cochrane ma'lumotlar bazasi. 1: CD004916. doi:10.1002 / 14651858.CD004916.pub4. ISSN 1469-493X. PMC 6984636. PMID 31930781.

[pmid27080256-4] Pediani JD, Uord RJ, Godin AG, Marsango S, Milligan G (iyun 2016). "M1 muskarinli retseptorlarini to'rtburchak tashkil etilishini subtip-selektiv antagonist dorilar tomonidan dinamik tartibga solish". Biologik kimyo jurnali. 291 (25): 13132–46. doi:10.1074 / jbc.M115.712562. PMC 4933229. PMID 27080256.

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v t e Giyohvand moddalar oshqozon yarasi va GERD / GORD (A02B)
H₂ antagonistlar ("-tidin")	Simetidin Famotidin Lafutidin Lavoltidin (loxtidin) Niperotidin Nizatidin Ranitidin^# Roksatidin
Prostaglandinlar (E) /analoglari ("-prost-")	Misoprostol Enprostil
Proton-nasos inhibitörleri ("-prazole")	Azeloprazol Dexlansoprazol Esomeprazol Ilaprazol Lansoprazol Omeprazol^# Pantoprazol Pikoprazol Rabeprazol Tenatoprazol Timoprazol
Kaliy bilan raqobatdosh kislota blokerlari ("-prazan")	Linaprazan Revaprazan Soraprazan Vonoprazan
Boshqalar	Aceglutamid alyuminiy Asetoksolon Alginik kislota Arbaklofen platsarbil Bizmut subkitrat Karbenoksolon Ketraksat Gefarnate Lesogaberan Pirenzepin Proglumid Rebamipid Sukralfat Sulglikotid Telenzepin Teprenon Troxipid Sink L-karnosin Zolimidin
Kombinatsiyalar	Bizmut subkitrat / metronidazol / tetratsiklin
Shuningdek qarang: Helicobacter pylori* yo'q qilish protokollari*
^#JSST-EM ^‡Olingan bozordan Klinik sinovlar: ^†III bosqich ^§Hech qachon III bosqichga

v t e Trisikliklar
Sinflar	Akridin Antrasen Dibenzazepin Dibenzotsiklohepten Dibenzodiazepin Dibenzotiazepin Dibenzotiepin Dibenzoksazepin Dibenzoksepin Fenotiazin Piridazinobenzoksazin Piridinobenzodiazepin Tioksanten
Antidepressantlar (TCAlar va TeCA)	7-OH-Amoksapin Amezepine Amineptin Amitriptilin Amitriptilinoksid Amoksapin Aptazapin Azepindol Azipramin Batelapin Butriptilin Sianopramin Tsiklazindol Tsiklopramin Sidoksepin Klomipramin Kotriptilin Siyanotiyepin Demeksiptilin Depramin (balipramin) Desipramin (desmetilimipramin) Desmetilklomipramin Desmetiltrimipramin Dibenzepin Dimetakrin Dozulepin (dotiepin) Doksepin Enprazepin Esmirtazapin Fantridon Fluotrasen Gepzidin Gomopipramol Imipramin Imipraminoksid Intriptilin Iprindol Ketipramin Litrasen Lofepramin Losindol Loksapin Maprotilin Mariptilin Mazindol Melitrasen Metapramin Mezepin Mianserin Mirtazapin Monometakrin Naranol Nitroksazepin Norbutriptilin Nordoksepin Northiaden (nordosulepin) Nortriptilin (noramitriptilin) Noksiptilin Octriptilin Opipramol Oksaprotilin Pipofezin Pirandamin Propizepin Protriptilin Kinupramin Setiptilin (teciptiline) Spiroksepin Tandamin Tampramin Tianeptin Tienopramin Trimipramin
Antihistaminiklar	Azatadin Bisulepin Klobenzepam Siproheptadin Dacemazine Deptropin Desloratadin Epinastin Etimemazin Fenetazin Gidroksietilprometazin Izoprometazin Izotipendil Ketotifen Latrepirdin Loratadin Mebhidrolin Mequitazin Metdilazin Olopatadin Oksomemazin Fenindamin Pimeteksen Prometazin Propiomazin Rupatadin Tiazinamium
Antipsikotiklar	Asetofenazin Alimemazin Amoksapin Asenapin Butaklamol Butaperazin Karfenazin (karfenazin) Karpipramin Xlorpromazin Xlorprotixen Tsiklindol Citatepin Klokapramin Klomakran Klorotepin Clotiapine Klozapin Siyanotepin Dlotlotepin Dokloksitepin Erizepin Flukindol Flumezapin Fluotrasen Flupentiksol Flüfenazin Gevotrolin Gomopipramol Izofloksitepin Levomepromazin / Metotrimeprazin Loksapin Lurasidon Maroksepin Meperatiyepin Mesoridazin Metiapin Metitepin Metoksepin Mosapramin Naranol Oktometotepin Olanzapin Oksiklotepin Oksiprotepin Pentiapin Peraditiyepin Perathiepin Perazin Perfenazin Periciazin Pinoksepin Piperatsetazin Pipotiazin Pikindon Proxlorperazin Promazin Protipendil Ketiapin Savoksepin / sipazoksapin Sulforidazin Tenilapin Tietilperazin Tiyopropazat Tioridazin Thiothixene Tilozepin Traboksopin Trifluoperazin Triflupromazin Triflutepin Zotepin Zuklopentiksol
Antikonvulsanlar	Karbamazepin Dizosilpin Eslikarbazepin Eslikarbazepin asetat Etazepin Likarbazepin Okskarbazepin Oksitriptilin Rispenzepin
Boshqalar	Adozopin Aminopromazin Atiprosin Beloksepin Benzoktamin Carvedilol Sidoksepin Siklobenzaprin Damotepin Darenzepin Elanzepin Fluradolin Metilen ko'k Monatepil Nuvenzepin Oksetoron Perlapin P7C3 Pinadolin Pirenzepin Pirolat Pitrazepin Pizotifen Profenamin Serazapin Siltenzepin Telenzepin Tipindol Tropatepin Zolenzepin

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