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Azepindole

Azepindol
Klinik ma'lumotlar

ATC kodi	yo'q
Identifikatorlar
IUPAC nomi 2,3,4,5-tetrahidro-1H- [1,4] diazepino [1,2-a] indol
CAS raqami	26304-61-0^N
PubChem CID	33471
ChemSpider	30893^Y
UNII	6BB6FW9T8J
KEGG	D03035^Y
ChEMBL	ChEMBL10758^Y
CompTox boshqaruv paneli (EPA)	DTXSID40180916
Kimyoviy va fizik ma'lumotlar
Formula	C₁₂H₁₄N₂
Molyar massa	186.258 g · mol⁻¹
3D model (JSmol)	Interaktiv rasm
Jilmayganlar c13c (cc2n1CCCNC2) cccc3
InChI InChI = 1S / C12H14N2 / c1-2-5-12-10 (4-1) 8-11-9-13-6-3-7-14 (11) 12 / h1-2,4-5,8, 13H, 3,6-7,9H2^Y Kalit: FEJCIXJKPISCJV-UHFFFAOYSA-N^Y
^NY (bu nima?) (tasdiqlash)

Azepindol (McN-2453) a trisiklik birikma bilan antidepressant va gipertenziv 1960 yillarning oxirida ishlab chiqilgan, ammo hech qachon bozorga chiqarilmagan effektlar.^[1]

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Trisiklik antidepressant

Adabiyotlar

^ Ganellin CR, Triggle DJ (1996 yil 21-noyabr). Farmakologik vositalar lug'ati - Google Books. ISBN 9780412466304.

Antidepressantlar (N06A)

Maxsus qaytarib olish inhibitörleri va / yoki retseptorlari modulyatorlari

SSRIlar	Citalopram Eskitalopram Fluoksetin^# Fluvoksamin Indalpin^‡ Paroksetin Sertralin Zimelidin^‡
SNRIlar	Desvenlafaksin Duloksetin Levomilnatsipran Milnacipran Tofenatsin Venlafaksin
NRIlar	Atomoksetin Reboksetin Viloksazin
NDRIlar	Amineptin^‡ Bupropion Nomifensin^‡
NaSSA	Mianserin Mirtazapin Setiptiline
SARIlar	Etoperidon Nefazodon Trazodone
SMS	Vilazodone Vortioksetin
Boshqalar	Agomelatin Amisulprid Esketamin^† Etripamin^‡ Indeksoksin flupentiksol Ketamin^† Medifoksamin^‡ Metripamin^‡ Oksaflozan^‡ Pivagabin^‡ Tandospiron Teniloksazin Tianeptin

Trisiklik va tetratsiklik antidepressantlar

TCAlar	Amineptin^‡ Amitriptilin^# Amitriptilinoksid Butriptilin^‡ Klomipramin^# Demeksiptilin^‡ Desipramin Dibenzepin Dimetakrin^‡ Dosulepin Doksepin Imipramin Imipraminoksid^‡ Iprindol^‡ Lofepramin Melitrasen Metapramin^‡ Nitroksazepin Nortriptilin Noksiptilin Opipramol Pipofezin Propizepin^‡ Protriptilin Kinupramin^‡ Tianeptin Trimipramin
TeCA	Amoksapin Maprotilin Mianserin Mirtazapin Setiptiline
Boshqalar	Tiazesim

Monoamin oksidaz inhibitörleri

Tanlanmagan	Qaytarib bo'lmaydigan: Benmoksin^‡ Iproklozid^‡ Iproniazid^‡ Izokarboksazid Isoniazid^# Linezolid^# Mebanazin^‡ Nialamid^‡ Oktamoksin^‡ Fenelzin Feniprazin^‡ Fenoksipropazin^‡ Pivhidrazin^‡ Safrazin^‡ Tedizolid Tranilsipromin Qaytariladigan: Karoksazon^‡ Aralashgan: Bifemelane
MAO_A-selektiv	Qaytariladigan: Eprobemid Metralindol Minaprin^‡ Moklobemid Pirindol Tetrindol Toloksaton
MAO_B-selektiv	Qaytarib bo'lmaydigan: Selegilin

Qo'shimcha davolash usullari
Atipik antipsikotiklar (aripiprazol, brekspiprazol, lurasidon, olanzapin, ketiapin, risperidon) Buspirone Lityum (lityum karbonat, lityum sitrat) Qalqonsimon bez gormonlari (triiodotironin (T₃), levotiroksin (T₄))

Turli xil
Ademetionin (Bir xil) Hypericum perforatum (Avliyo Ioann wort) Oksitriptan (5-HTP) Rubidiy xlorid (RbCl) Triptofan

^#JSST-EM
^‡Olingan bozordan
Klinik sinovlar:
- ^†III bosqich
- ^§Hech qachon III bosqichga

Simfatolitik (va chambarchas bog'liq) antihipertensivlar (C02)

Simfatolitiklar
(qarama-qarshilik) a-adrenerjik
vazokonstriksiya)

Markaziy

a₂ agonist	Klonidin Guanabenz Guanfasin Metildopa^# Tiamenidin^‡
Adrenergik ajratish inhibitörleri	Betanidin Bretilyum Debrisokin Guanadrel Guanazodin Guanetidin Guanoklor Guanoksabenz Guanoxan
Imidazolin retseptorlari agonist	Moksonidin Rilmenidin Tolonidin
Ganglionlarni blokirovka qilish/nikotinik antagonist	Geksametoniya^‡ Mekamilamin Pentolinium Trimetafan

Periferik

Bilvosita

MAOI	Pargilin^‡
Adrenerjik qabul qilish inhibitori	Bietaserpin Deserpidin Metoserpidin Rescinnamine Reserpine Sirozingopin
Tirozin gidroksilaza inhibitori	Metirozin

To'g'ridan-to'g'ri

a₁ blokerlar	Prazosin Indoramin Trimazosin Doksazosin Urapidil
Selektiv bo'lmagan a bloker	Fentolamin

Boshqalar antagonistlar

Serotonin antagonisti	Ketanserin Lidanserin
Endotelin antagonisti (uchun PH)	ikkilamchi (Bosentan, Macitentan) tanlangan (Ambrisentan, Sitaksentan)

^#JSST-EM
^‡Olingan bozordan
Klinik sinovlar:
- ^†III bosqich
- ^§Hech qachon III bosqichga

v t e Trisikliklar
Sinflar	Akridin Antrasen Dibenzazepin Dibenzotsiklohepten Dibenzodiazepin Dibenzotiazepin Dibenzotiepin Dibenzoksazepin Dibenzoksepin Fenotiazin Piridazinobenzoksazin Piridinobenzodiazepin Tioksanten
Antidepressantlar (TCAlar va TeCA)	7-OH-Amoksapin Amezepine Amineptin Amitriptilin Amitriptilinoksid Amoksapin Aptazapin Azepindol Azipramin Batelapin Butriptilin Sianopramin Tsiklazindol Tsiklopramin Sidoksepin Klomipramin Kotriptilin Siyanotiyepin Demeksiptilin Depramin (balipramin) Desipramin (desmetilimipramin) Desmetilklomipramin Desmetiltrimipramin Dibenzepin Dimetakrin Dozulepin (dotiepin) Doksepin Enprazepin Esmirtazapin Fantridon Fluotrasen Gepzidin Gomopipramol Imipramin Imipraminoksid Intriptilin Iprindol Ketipramin Litrasen Lofepramin Losindol Loksapin Maprotilin Mariptilin Mazindol Melitrasen Metapramin Mezepin Mianserin Mirtazapin Monometakrin Naranol Nitroksazepin Norbutriptilin Nordoksepin Northiaden (nordosulepin) Nortriptilin (noramitriptilin) Noksiptilin Octriptilin Opipramol Oksaprotilin Pipofezin Pirandamin Propizepin Protriptilin Kinupramin Setiptilin (teciptiline) Spiroksepin Tandamin Tampramin Tianeptin Tienopramin Trimipramin
Antihistaminiklar	Azatadin Bisulepin Klobenzepam Siproheptadin Dacemazine Deptropin Desloratadin Epinastin Etimemazin Fenetazin Gidroksietilprometazin Izoprometazin Izotipendil Ketotifen Latrepirdin Loratadin Mebhidrolin Mequitazin Metdilazin Olopatadin Oksomemazin Fenindamin Pimeteksen Prometazin Propiomazin Rupatadin Tiazinamium
Antipsikotiklar	Asetofenazin Alimemazin Amoksapin Asenapin Butaklamol Butaperazin Karfenazin (karfenazin) Karpipramin Xlorpromazin Xlorprotixen Tsiklindol Citatepin Klokapramin Klomakran Klorotepin Clotiapine Klozapin Siyanotepin Dlotlotepin Dokloksitepin Erizepin Flukindol Flumezapin Fluotrasen Flupentiksol Flüfenazin Gevotrolin Gomopipramol Izofloksitepin Levomepromazin / Metotrimeprazin Loksapin Lurasidon Maroksepin Meperatiyepin Mesoridazin Metiapin Metitepin Metoksepin Mosapramin Naranol Oktometotepin Olanzapin Oksiklotepin Oksiprotepin Pentiapin Peraditiyepin Perathiepin Perazin Perfenazin Periciazin Pinoksepin Piperatsetazin Pipotiazin Pikindon Proxlorperazin Promazin Protipendil Ketiapin Savoksepin / sipazoksapin Sulforidazin Tenilapin Tietilperazin Tiyopropazat Tioridazin Thiothixene Tilozepin Traboksopin Trifluoperazin Triflupromazin Triflutepin Zotepin Zuklopentiksol
Antikonvulsanlar	Karbamazepin Dizosilpin Eslikarbazepin Eslikarbazepin asetat Etazepin Likarbazepin Okskarbazepin Oksitriptilin Rispenzepin
Boshqalar	Adozopin Aminopromazin Atiprosin Beloksepin Benzoktamin Carvedilol Sidoksepin Siklobenzaprin Damotepin Darenzepin Elanzepin Fluradolin Metilen ko'k Monatepil Nuvenzepin Oksetoron Perlapin P7C3 Pinadolin Pirenzepin Pirolat Pitrazepin Pizotifen Profenamin Serazapin Siltenzepin Telenzepin Tipindol Tropatepin Zolenzepin

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