WikiDer > Dihidrodeoksikortikosteron

Dihidrodeoksikortikosteron
Ismlar
	IUPAC nomi (5a) -21-Gidroksipregnan-3,20-dion
	Boshqa ismlar 5a-Dihidro-11-deoksikortikosteron
Identifikatorlar
CAS raqami	298-36-2;
3D model (JSmol)	Interaktiv rasm;
ChemSpider	4953958;
PubChem CID	6451493;
CompTox boshqaruv paneli (EPA)	DTXSID40952236 ;
	InChI InChI = 1S / C21H32O3 / c1-20-9-7-14 (23) 11-13 (20) 3-4-15-16-5-6-18 (19 (24) 12-22) 21 (16, 2) 10-8-17 (15) 20 / h13,15-18,22H, 3-12H2,1-2H3 / t13-, 15-, 16-, 17-, 18 +, 20-, 21- / m0 / s1 Kalit: USPYDUPOCUYHQL-KVHKMPIWSA-N; InChI = 1 / C21H32O3 / c1-20-9-7-14 (23) 11-13 (20) 3-4-15-16-5-6-18 (19 (24) 12-22) 21 (16, 2) 10-8-17 (15) 20 / h13,15-18,22H, 3-12H2,1-2H3 / t13-, 15-, 16-, 17-, 18 +, 20-, 21- / m0 / s1 Kalit: USPYDUPOCUYHQL-KVHKMPIWBY;
	Jilmayganlar C [C @] 12CCC (= O) C [C @@ H] 1CC [C @@ H] 3 [C @@ H] 2CC [C @] 4 ([C @ H] 3CC [C @@ H] 4C (= O) CO) C;
Xususiyatlari
Kimyoviy formulalar	C21H32O3
Molyar massa	332.484 g · mol−1
	Boshqacha ko'rsatilmagan hollar bundan mustasno, ulardagi materiallar uchun ma'lumotlar keltirilgan standart holat (25 ° C [77 ° F], 100 kPa da).
	Infobox ma'lumotnomalari

Dihydrodeoxycorticosterone

5a-Dihidrodeoksikortikosteron (qisqartirilgan DHDOC), shuningdek, nomi bilan tanilgan 21-gidroksi-5a-homiladorlik-20-bir, bu endogen progestogen va neurosteroid.^[1] U sintezlanadi buyrak usti gormoni deoksikortikosteron (DOC) tomonidan ferment 5a-reduktaza I turi.^[1] DHDOC an agonist ning progesteron retseptorlari, shuningdek ijobiy allosterik modulyator ning GABA_A retseptorlariva borligi ma'lum antikonvulsant effektlar.^[1]^[2]

Kimyo

Shuningdek qarang

Adabiyotlar

^ ^a ^b ^v Reddy DS, Rogawski MA (may 2002). "Stress bilan bog'liq bo'lgan deoksikortikosterondan kelib chiqqan neyosteroidlar GABA (A) retseptorlari funktsiyasini va tutilish sezuvchanligini modulyatsiya qiladi".. J. Neurosci. 22 (9): 3795–805. doi:10.1523 / JNEUROSCI.22-09-03795.2002. PMID 11978855.
^ Edvards HE, Vimal S, Burnham WM (dekabr 2005). "Rivojlanayotgan kalamushlarda deoksikortikosteronning antikonvulsan ta'siri: metabolitlarning roli va mineralokortikoid-retseptorlari reaktsiyalari". Epilepsiya. 46 (12): 1888–97. doi:10.1111 / j.1528-1167.2005.00295.x. PMID 16393154. S2CID 26030656.

[pmid11978855-1] v Reddy DS, Rogawski MA (may 2002). "Stress bilan bog'liq bo'lgan deoksikortikosterondan kelib chiqqan neyosteroidlar GABA (A) retseptorlari funktsiyasini va tutilish sezuvchanligini modulyatsiya qiladi".. J. Neurosci. 22 (9): 3795–805. doi:10.1523 / JNEUROSCI.22-09-03795.2002. PMID 11978855.

[pmid16393154-2] Edvards HE, Vimal S, Burnham WM (dekabr 2005). "Rivojlanayotgan kalamushlarda deoksikortikosteronning antikonvulsan ta'siri: metabolitlarning roli va mineralokortikoid-retseptorlari reaktsiyalari". Epilepsiya. 46 (12): 1888–97. doi:10.1111 / j.1528-1167.2005.00295.x. PMID 16393154. S2CID 26030656.

[1]

[2]

v t e GABA_A retseptorlari ijobiy modulyatorlari
Spirtli ichimliklar	Brometon Butanol Xloralodol Xlorobutanol (kloreton) Etanol (alkogol) (alkogolli ichimlik) Etxlorvinol Izobutanol Izopropanol Mentol Metanol Metilpentinol Pentanol Petrikloral Propanol tert-Butanol (2M2P) tert-Pentanol (2M2B) Tribromoetanol Trikloroetanol Triklofos Trifloroetanol
Barbituratlar	(-) - DMBB Allobarbital Alfenal Amobarbital Aprobarbital Barbeksaklon Barbital Benzobarbital Benzilbutilbarbiturat Brallobarbital Brophebarbital Butabarbital / Secbutabarbital Butalbital Buthalital Butobarbital Butallylonal Uglerod Krotilbarbital Siklobarbital Siklopentobarbital Difebarbamat Enalilpropimal Etallobarbital Eterobarb Febarbamat Heptabarb Geptobarbital Geksetal Geksobarbital Metarbital Metitural Metekeksital Metilfenobarbital Narkobarbital Nealbarbital Pentobarbital Fenalmal Fenobarbital Fetarbital Primidon Probarbital Propallylonal Propilbarbital Proksibarbital Qaytarish Sekobarbital Sigmodal Spirobarbital Talbutal Tetrabamat Tetrabarbital Thialbarbital Tiamilal Tiobarbital Thiobutabarbital Thiopental Thiotetrabarbital Valofan Vinbarbital Vinilbital
Benzodiazepinlar	2-oksokazepam 3-gidroksifenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Brotizolam Kamazepam Karburazepam Xlordiazepoksid Tsiklotizolam Cinazepam Cinolazepam Klazolam Klimazolam Clobazam Klonazepam Klonazolam Kloniprazepam Klorazepat Clotiazepam Kloksazolam CP-1414S Kiprazepam Delorazepam Demoksepam Diazepam Diklazepam Doksefazepam Elfazepam Estazolam Etil karfluzepat Etil dirazepat Etil loflazepat Etizolam EVT-201 FG-8205 Fletazepam Flubromazepam Flubromazolam Fludiazepam Flunitrazepam Flunitrazolam Flurazepam Flutazolam Flutemazepam Flutoprazepam Fosazepam Gidazepam Halazepam Haloksazolam Iclazepam Imidazenil Irazepin Ketazolam Lofendazam Lopirazepam Loprazolam Lorazepam Lormetazepam Meklonazepam Medazepam Menitrazepam Metaklazepam Mexazolam Midazolam Motrazepam N-Desalkilflurazepam Nifoksipam Nimetazepam Nitrazepam Nitrazepat Nitrazolam Nordazepam Nortetrazepam Oksazepam Oksazolam Fenazepam Pinazepam Pivoksazepam Prazepam Premazepam Proflazepam Pirazolam QH-II-66 Kvazepam Reclazepam Remimazolam Rilmazafone Ripazepam Ro48-6791 Ro48-8684 SH-053-R-CH3-2′F Sulazepam Temazepam Tetrazepam Tolufazepam Triazolam Triflubazam Triflunordazepam (Ro5-2904) Tuclazepam Uldazepam Zapizolam Zolazepam Zomebazam
Karbamatlar	Karisbamat Karizoprodol Klocental Siklarbamat Difebarbamat Emilkamat Etinamat Febarbamat Felbamat Geksapropimat Lorbamat Mebutamat Meprobamat Nisobamat Pentabamat Fenprobamat Prokurat Stiramat Tetrabamat Tybamate
Flavonoidlar	6-metilapigenin Ampelopsin (dihidromiritsetin) Apigenin Baicalein Baikalin Katexin EGC EGCG Hispidulin Linarin Luteolin Rc-OMe Bosh suyagi tarkibiy qismlar (masalan, baikalin) Vogonin
Imidazollar	Etomidate Metomidat Propoksat
Kava tarkibiy qismlar	10-metoksiyangonin 11-metoksiyangonin 11-gidroksiyangonin Desmetoksiyangonin 11-metoksi-12-gidroksidigidrokavain 7,8-Dihidroyangonin Kavain 5-gidroksikavain 5,6-Dihidroyangonin 7,8-Dihidrokavain 5,6,7,8-Tetrahidroyangonin 5,6-dehidrometististin Metistitsin 7,8-Dihidrometistitsin Yangonin
Monoureidlar	Acecarbromal Apronal (apronalid) Bromisoval Karbromal Kapurid Ektilüre
Neyroaktiv steroidlar	Acebrochol Allopregnanolon (brexanolon) Alfadolon Alfaxalone 3a-Androstandiol Androstenol Androsteron Aniq anabolik-androgenik steroidlar Xolesterin DHDOC 3a-DHP 5a-DHP 5β-DHP DHT Etioxolanolon Ganaxolone Gidroksidion Minaxolon ORG-20599 ORG-21465 P1-185 Pregnanolon (eltanolon) Progesteron Renanolon SAGE-105 SAGE-324 SAGE-516 SAGE-689 SAGE-872 Testosteron THDOC Zuranolone
Nonbenzodiazepinlar	Siklopirrolonlar: Eszopiklon Pagoklon Pazinaklon Suproklon Suriklon Zopiklon Imidazopiridinlar: Alpidem DS-1 Nekopidem Saripidem Zolpidem Pirazolopirimidinlar: Divaplon Fasiplon Indiplon Lidorli diplom Ocinaplon Panadiplon Taniplon Zaleplon Boshqalar: Adipiplon CGS-8216 CGS-9896 CGS-13767 CGS-20625 CL-218,872 CP-615,003 CTP-354 ELB-139 GBLD-345 Imepitoin JM-1232 L-838,417 Lirequinil (Ro41-3696) NS-2664 NS-2710 NS-11394 Pipequaline ROD-188 RWJ-51204 SB-205,384 SX-3228 TGSC01AA TP-003 TPA-023 TP-13 U-89843A U-90042 Viqualin Y-23684
Fenollar	Fospropofol Propofol Timol
Piperidinediones	Glutetimid Metiprilon Piperidion Piritildion
Pirazolopiridinlar	Kartazolat Etazolat ICI-190,622 Trakazolat
Kinazolinonlar	Aflokalon Klorokalon Diproqualone Etaqualon Mebroqualone Meklokalon Metakualone Metilmetakualon Nitrometakualon SL-164
Uchuvchi/gazlar	Aseton Asetofenon Asetilglisinamid xloralgidrat Alifluran Benzol Butan Butilen Centalun Xloral Xloral betain Xlorli gidrat Xloroform Kriyofloran Desfluran Dikloralfenazon Diklorometan Dietil efir Enfluran Etil xlorid Etilen Fluroksen Benzin Halopropan Halotan Isofluran Kerosin Metoksifluran Metoksipropan Azot oksidi Azot Azot oksidi Norfluran Paraldegid Propan Propilen Rofluran Sevofluran Sintan Tefluran Toluen Trikloretan (metil xloroform) Trikloretilen Vinil efir
Boshqalar / saralanmagan	3-gidroksibutanal a-EMTBL AA-29504 Avermektinlar (masalan, ivermektin) Bromid birikmalar (masalan, lityum bromid, kaliy bromidi, natriy bromidi) Karbamazepin Xloraloza Xlormezanon Klometiyazol DEABL Dihidroergolinlar (masalan, dihidroergokriptin, dihidroergozin, dihidroergotamin, ergoloid (dihidroergotoksin)) DS2 Efavirenz Etazepin Etifoksin Fenamatlar (masalan, flufenamik kislota, mefenamik kislota, niflumik kislota, tolfenamik kislota) Fluoksetin Flupirtin Hopantenik kislota Lantan Lavanda yog'i Lignanlar (masalan, 4-O-metilxonokiol, honokiol, magnolol, obovatol) Loreclezole Mentil izovalerat (validolum) Monastrol Niasin Nikotinamid (niatsinamid) Org 25,435 Fenitoin Propanidid Retigabin (ezogabine) Safranal Seproksetin Stiripentol Sulfonilalkanlar (masalan, sulfanmetan (sulfanal), tetronal, trional) Terpenoidlar (masalan, borneol) Topiramat Valeriya tarkibiy qismlar (masalan, izovaler kislotasi, izovaleramid, valeren kislotasi, valerenol) Saralangan benzodiazepin saytining ijobiy modulyatorlari: a-Pinene MRK-409 (MK-0343) TCS-1105 TCS-1205
Shuningdek qarang: Retseptor / signalizatsiya modulyatorlari • GABA retseptorlari modulyatorlari • GABA metabolizmi / transport modulyatorlari

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Kimyo

Shuningdek qarang

Adabiyotlar

Ismlar

IUPAC nomi (5a) -21-Gidroksipregnan-3,20-dion
Boshqa ismlar 5a-Dihidro-11-deoksikortikosteron
Identifikatorlar
CAS raqami	298-36-2
3D model (JSmol)	Interaktiv rasm
ChemSpider	4953958
PubChem CID	6451493
CompTox boshqaruv paneli (EPA)	DTXSID40952236
InChI InChI = 1S / C21H32O3 / c1-20-9-7-14 (23) 11-13 (20) 3-4-15-16-5-6-18 (19 (24) 12-22) 21 (16, 2) 10-8-17 (15) 20 / h13,15-18,22H, 3-12H2,1-2H3 / t13-, 15-, 16-, 17-, 18 +, 20-, 21- / m0 / s1 Kalit: USPYDUPOCUYHQL-KVHKMPIWSA-N InChI = 1 / C21H32O3 / c1-20-9-7-14 (23) 11-13 (20) 3-4-15-16-5-6-18 (19 (24) 12-22) 21 (16, 2) 10-8-17 (15) 20 / h13,15-18,22H, 3-12H2,1-2H3 / t13-, 15-, 16-, 17-, 18 +, 20-, 21- / m0 / s1 Kalit: USPYDUPOCUYHQL-KVHKMPIWBY
Jilmayganlar C [C @] 12CCC (= O) C [C @@ H] 1CC [C @@ H] 3 [C @@ H] 2CC [C @] 4 ([C @ H] 3CC [C @@ H] 4C (= O) CO) C
Xususiyatlari
Kimyoviy formulalar	C₂₁H₃₂O₃
Molyar massa	332.484 g · mol⁻¹
Boshqacha ko'rsatilmagan hollar bundan mustasno, ulardagi materiallar uchun ma'lumotlar keltirilgan standart holat (25 ° C [77 ° F], 100 kPa da).
Infobox ma'lumotnomalari